Nav: Home

Obesity affects prostate cancer test results

July 05, 2018

University of Adelaide research shows that the results of the most widely used test for prostate cancer may be affected by obesity.

With increasing prevalence of obesity in high-income countries, this study published by the Society for Endocrinology, has important implications for detecting and monitoring the most common form of cancer in men.

Using data from 970 South Australian men from the Florey Adelaide Male Ageing Study, PhD student and medical oncologist Dr Adel Aref from the University's Adelaide Medical School and the Freemasons Foundation Centre for Men's Health, studied the effects of obesity on PSA levels detected in blood and the influence of the hormones, testosterone and estrogen.

Elevated levels of prostate specific antigen (PSA) in the blood can be an indicator of prostate cancer and lead to further diagnostic investigations," says Dr Aref.

PSA is increased by the male sex steroid hormone, testosterone. "We have shown for the first time that the concentration of PSA in the blood is lower in men with severe obesity (with a body mass index or BMI of 30 or higher) than in lean men, and that this can be attributed to lower concentrations of circulating testosterone".

"The results of this study have important implications for how we should interpret PSA levels in men who are obese," says project supervisor Professor Gary Wittert, Director of the Freemasons Foundation Centre for Men's Health and the Adelaide Medical School at the University of Adelaide and SAHMRI.

"Obesity is a major risk factor in the development of cancer, as well as other diseases. More than 65% of men in Australia are overweight or obese and this level is predicted to increase.

"Further studies are now required to investigate effective strategies for applying this knowledge in clinical practice" says Professor Wittert.
-end-


University of Adelaide

Related Prostate Cancer Articles:

First prostate cancer therapy to target genes delays cancer progression
For the first time, prostate cancer has been treated based on the genetic makeup of the cancer, resulting in delayed disease progression, delayed time to pain progression, and potentially extending lives in patients with advanced, metastatic prostate cancer, reports a large phase 3 trial.
Men taking medications for enlarged prostate face delays in prostate cancer diagnosis
University of California San Diego School of Medicine researchers report that men treated with medications for benign prostatic hyperplasia (enlarged prostate) experienced a two-year delay in diagnosis of their prostate cancer and were twice as likely to have advanced disease upon diagnosis.
CNIO researchers confirm links between aggressive prostate cancer and hereditary breast cancer
The study has potential implications for families with members suffering from these types of tumours who are at an increased risk of developing cancer.
Distinguishing fatal prostate cancer from 'manageable' cancer now possible
Scientists at the University of York have found a way of distinguishing between fatal prostate cancer and manageable cancer, which could reduce unnecessary surgeries and radiotherapy.
Researchers find prostate cancer drug byproduct can fuel cancer cells
A genetic anomaly in certain men with prostate cancer may impact their response to common drugs used to treat the disease, according to new research at Cleveland Clinic.
More Prostate Cancer News and Prostate Cancer Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Erasing The Stigma
Many of us either cope with mental illness or know someone who does. But we still have a hard time talking about it. This hour, TED speakers explore ways to push past — and even erase — the stigma. Guests include musician and comedian Jordan Raskopoulos, neuroscientist and psychiatrist Thomas Insel, psychiatrist Dixon Chibanda, anxiety and depression researcher Olivia Remes, and entrepreneur Sangu Delle.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...