Nav: Home

Algae extract increases good cholesterol levels, Wayne State research finds

July 06, 2012

Detroit - A Wayne State University researcher has found that an extract from algae could become a key to regulating cardiovascular disease.

In a study funded by Health Enhancement Products of Bloomfield Hills, Mich., Smiti Gupta, Ph.D., assistant professor in the department of nutrition and food science in the College of Liberal Arts and Sciences, has found that dietary intake of ProAlgaZyme increased the level of high-density lipoprotein (HDL) in an animal model.

While medications for the control of high plasma cholesterol levels such as statins and numerous dietary supplements primarily function by lowering levels of low-density lipoproteins (LDL), or "bad cholesterol," Gupta's research explores the effects of raising levels of HDL, or "good cholesterol," which work in part by carrying cholesterol out of the arterial wall.

Results of her study, titled "ProAlgaZyme and its Sub-fractions Increase Plasma HDL-Cholesterol via Up Regulation of ApoA1, ABCA1 and SRB1 and Inhibition of CETP in Hypercholesterolemic Hamsters," were published recently in the Journal of Nutrition and Dietary Supplements.

"The cholesterol mechanism is crucial to heart disease," Gupta said. "Very few agents increase good cholesterol, but we found that this algae extract does. The ratio of total to HDL cholesterol improved significantly. This result, if replicated in humans, would be consistent with a decreased risk of heart disease."

ProAlgaZyme, a clear liquid, was administered as part of the drinking fluid over four weeks. In addition to increasing HDL levels, the group found that it also changed the expression of genes involved in the reverse cholesterol transport mechanism. And while they don't know exactly how it will function in humans, Gupta said other research suggests a similar outcome.

"Its biological effect over time and toxic effects, if any, need to be further investigated in a long-term study in an animal model before testing its effects in humans," she said. "But this is a step in the right direction, since increased HDL is considered an important therapeutic target for improvement of the lipid profile and thus reduction of the risk for cardiovascular disease."
-end-
Wayne State University is one of the nation's pre-eminent public research universities in an urban setting. Through its multidisciplinary approach to research and education, and its ongoing collaboration with government, industry and other institutions, the university seeks to enhance economic growth and improve the quality of life in the city of Detroit, state of Michigan and throughout the world. For more information about research at Wayne State University, visit http://www.research.wayne.edu.

Wayne State University - Office of the Vice President for Research

Related Cardiovascular Disease Articles:

Is educational attainment associated with lifetime risk of cardiovascular disease?
Men and women with the lowest education level had higher lifetime risks of cardiovascular disease than those with the highest education level, according to a new study published by JAMA Internal Medicine.
Food policies could lower US cardiovascular disease rates
New research conducted by the University of Liverpool and partners shows that food policies, such as fruit and vegetable subsidies, taxes on sugar sweetened drinks, and mass media campaigns to change dietary habits, could avert hundreds of thousands of deaths from cardiovascular disease (CVD) in the United States.
Cardiovascular disease causes one-third of deaths worldwide
Cardiovascular diseases (CVD), including heart diseases and stroke, account for one-third of deaths throughout the world, according to a new scientific study that examined every country over the past 25 years.
Kidney disease is a major cause of cardiovascular deaths
In 2013, reduced kidney function was associated with 4 percent of deaths worldwide, or 2.2 million deaths.
Cardiovascular disease costs will exceed $1 trillion by 2035
A new study projects that by 2035, cardiovascular disease, the most costly and prevalent killer, if left unchecked, will place a crushing economic and health burden on the nation's financial and health care systems.
Prescribing drugs for cardiovascular disease prevention in the UK
Drugs such as statins that have the potential to prevent strokes and other types of cardiovascular disease have not been prescribed to a large proportion of people at risk in the UK, according to a research article by Grace Turner of the University of Birmingham, Birmingham, UK and colleagues published in PLOS Medicine.
Fatty liver disease contributes to cardiovascular disease and vice versa
For the first time, researchers have shown that a bi-directional relationship exists between fatty liver disease and cardiovascular disease.
More dietary calcium may lower risk of cardiovascular disease
In older people, higher dietary calcium intake may lower the risk of cardiovascular disease, but not of stroke and fracture, new research from South Korea suggests.
Renal hemodynamics and cardiovascular function in health and disease
The SRC will focus on unpublished work that is state-of-the-art in study of cardiovascular and renal disease and hypertension.
Cardiovascular disease in adult survivors of childhood cancer
For adult survivors of childhood cancer, cardiovascular disease presents at an earlier age, is associated with substantial morbidity, and is often asymptomatic.

Related Cardiovascular Disease Reading:

Cardiovascular Disease: Fight it with the Blood Type Diet: The Individualized Plan for Treating Heart Conditions, High Blood Pressure, High ... (Eat Right 4 (For) Your Type Health Library)
by Dr. Peter J. D'Adamo (Author), Catherine Whitney (Author)

Dr. Peter J. D'Adamo, the author of the Eat Right 4 (for) Your Blood Type Diet series, with more than two million copies in print, has now created a targeted plan for fighting arthritis and cardiovascular disease. Using specific tools not available in any other book, sufferers can find their own, individualized battle plan for defeating the pain of these debilitating diseases.

Here, D'Adamo offers individualized battle plans for preventing and treating heart conditions, high blood pressure, high cholesterol, vascular problems, and angina.

View Details


Pathophysiology of Heart Disease: A Collaborative Project of Medical Students and Faculty
by Leonard S. Lilly MD (Author)

Publisher’s Note:   Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product.

Specifically designed to prepare medical students for their initial encounters with patients with heart disease, this award-winning text bridges basic cardiac physiology with clinical care. Written by internationally recognized Harvard Medical School faculty and select medical students, Pathophysiology of Heart Disease, Sixth Edition provides a solid foundation of knowledge... View Details


Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 2-Volume Set, 10e
by Douglas L. Mann MD (Author), Douglas P. Zipes MD (Author), Peter Libby MD PhD (Author), Robert O. Bonow MD MS (Author)

2015 BMA Medical Book Awards 1st Prize Award Winner in Cardiology Category! Ideal for cardiologists who need to keep abreast of rapidly changing scientific foundations, clinical research results, and evidence-based medicine, Braunwald’s Heart Disease is your indispensable source for definitive, state-of-the-art answers on every aspect of contemporary cardiology. It helps you apply the most recent knowledge in personalized medicine, imaging techniques, pharmacology, interventional cardiology, electrophysiology, and much more!

In keeping with the... View Details


Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 2-Volume Set, 11e
by Douglas P. Zipes MD (Author), Peter Libby MD PhD (Author), Robert O. Bonow MD MS (Author), Douglas L. Mann MD (Author), Gordon F. Tomaselli MD (Author)

Trusted by generations of cardiologists for the latest, most reliable guidance in the field, Braunwald’s Heart Disease, 11th Edition, remains your #1 source of information on rapidly changing clinical science, clinical and translational research, and evidence-based medicine. This award-winning text has been completely updated, providing a superior multimedia reference for every aspect of this fast-changing field, including new material about almost every topic in cardiology.

A unique update program by Dr. Braunwald creates a "living textbook" by featuring... View Details


Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 2-Volume Set
by Peter Libby MD PhD (Author), Robert O. Bonow MD MS (Author), Douglas P. Zipes MD (Author), Douglas L. Mann MD (Author)

Dr. Braunwald's masterwork returns … bringing you the definitive guidance you need to overcome any challenge in clinical cardiology today, using the best approaches available! Hundreds of world authorities, many of them new to this edition, synthesize all of the recent developments that are revolutionizing practice – from the newest findings in molecular biology and genetics to the latest imaging modalities, interventional procedures, and medications. This multimedia e-dition includes not only the printed reference, but also access to the complete contents online, fully searchable, with... View Details


Cardiac CT Imaging: Diagnosis of Cardiovascular Disease
by Matthew J. Budoff (Editor), Jerold S. Shinbane (Editor)

This book collates all the current knowledge of cardiac CT and presents it in a clinically relevant and practical textbook format appropriate for both cardiologists and radiologists. The images have been supplied by an experienced set of contributing authors and represent the full spectrum of cardiac CT.

The field of Cardiovascular CT has experienced continued rapid evolution due to:  1)  advances in technology, 2) expanded spectrum of cardiovascular applications and 3)  significant growth in published data including large prospective multicenter studies.  

As... View Details


Cardiovascular Care Made Incredibly Easy (Incredibly Easy! Series®)
by Lippincott Williams & Wilkins (Author)

Publisher’s Note:   Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product.

Does your heart skip a beat every time you think about the complexities of providing cardio care? Well, not anymore!

Written in the award-winning Incredibly Easy! style, this completely updated Third Edition of Cardiovascular Care Made Incredibly Easy is the ideal reference for those entering or needing a refresher in cardiovascular nursing care.

This... View Details


Cardiovascular Intervention: A Companion to Braunwald’s Heart Disease, 1e
by Deepak L. Bhatt MD MPH FACC FAHA FSCAI FESC (Author)

Introducing Cardiovascular Intervention, a comprehensive companion volume to Braunwald’s Heart Disease. This medical reference book contains focused chapters on how to utilize cutting-edge interventional technologies, with an emphasis on the latest protocols and standards of care. Cardiovascular Intervention also includes an eBook updated with late-breaking clinical trials, "Hot off the Press" commentary, and Focused Reviews that are relevant to interventional cardiology.

View immersive videos from an online library... View Details


Braunwald's Heart Disease Review and Assessment, 10e (Companion to Braunwald's Heart Disease)
by Leonard S. Lilly MD (Author)

The 10th Edition of Braunwald’s Heart Disease Review and Assessment, by Dr. Leonard S. Lilly, provides an updated, clear, and concise overview of essential aspects of cardiovascular medicine. Offered in print and online, more than 700 review questions - derived from the 10th Edition of Braunwald's Heart Disease - test your knowledge of all important concepts in cardiology today. Detailed answers comprise "mini-reviews" of the material, and cross references to the main text make it easy to find definitive explanations for questions... View Details


Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Single Volume, 8e (Heart Disease (Braunwald) (Single Vol))
by Peter Libby MD PhD (Author), Robert O. Bonow MD MS (Author), Douglas L. Mann MD (Author), Douglas P. Zipes MD (Author)

Dr. Braunwald's masterwork returns … bringing you the definitive guidance you need to overcome any challenge in clinical cardiology today, using the best approaches available! Hundreds of world authorities, many of them new to this edition, synthesize all of the recent developments that are revolutionizing practice – from the newest findings in molecular biology and genetics to the latest imaging modalities, interventional procedures, and medications. The expertise of the book's contributors, the scope of its coverage, and its richly illustrated, user-friendly format all make this the... View Details

Best Science Podcasts 2017

We have hand picked the best science podcasts for 2017. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Going Undercover
Are deception and secrecy categorically wrong? Or can they be a necessary means to an end? This hour, TED speakers share stories of going undercover to explore unknown territory, and find the truth. Guests include poet and activist Theo E.J. Wilson, journalist Jamie Bartlett, counter-terrorism expert Mubin Shaikh, and educator Shabana Basij-Rasikh.
Now Playing: Science for the People

#452 Face Recognition and Identity
This week we deep dive into the science of how we recognize faces and why some of us are better -- or worse -- at this than others. We talk with Brad Duchaine, Professor of Psychology at Dartmouth College, about both super recognizers and face blindness. And we speak with Matteo Martini, Psychology Lecturer at the University of East London, about a study looking at twins who have difficulty telling which one of them a photo was of. Charity Links: Union of Concerned Scientists Evidence For Democracy Sense About Science American Association for the Advancement of Science Association for Women...