3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia

July 07, 2014

The pathogenesis of vascular dementia induced by chronic cerebral ischemia is complex, mainly consisting of energy metabolism disorder, oxidative stress injury, neuronal apoptotic cell death and cholinergic nerve dysfunction. There is evidence that 3-n-butylphthalide can effectively antagonize acute ischemic stroke. However, the effect of 3-n-butylphthalide on chronic ischemic stroke remains unclear. Dr. Wanhong Zhao and her team, Institute of Basic Medical Sciences, Hubei University of Medicine, China performed a study and found that 3-n-butylphthalide improved neuronal morphology in cerebral cortex and hippocampus, alleviated oxidative stress caused by chronic cerebral ischemia, improved cholinergic function, and inhibited amyloid beta accumulation in rats subjected to chronic cerebral ischemia. Their findings were published in Neural Regeneration Research (Vol. 9, No. 7, 2014).
Article: "3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia" by Wanhong Zhao, Chao Luo, Jue Wang, Jian Gong, Bin Li, Yingxia Gong, Jun Wang, Hanqin Wang (Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei Province, China)

Zhao WH, Luo C, Wang J, Gong J, Li B, Gong YX, Wang J, Wang HQ. 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia. Neural Regen Res. 2014;9(7):719-726.


Meng Zhao
Neural Regeneration Research

Neural Regeneration Research

Related Pathogenesis Articles from Brightsurf:

Examining impact of a point mutation in SARS-Cov-2 spike on virus transmission and pathogenicity
The current dominant variant of SARS-CoV-2, containing a D614G substitution in the spike protein, appears to have evolved to enhance transmissibility, according to a new study in human cells and animal models.

The lung microbiome may affect lung cancer pathogenesis and prognosis
Enrichment of the lungs with oral commensal microbes was associated with advanced stage disease, worse prognosis, and tumor progression in patients with lung cancer, according to results from a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

Global study identifies common vulnerabilities across SARS-CoV-2, SARS-CoV-1 and MERS coronaviruses
There are common vulnerabilities among three lethal coronaviruses, SARS-CoV-2, SARS-CoV-1 and MERS-CoV, such as frequently hijacked cellular pathways, that could lead to promising targets for broad coronavirus inhibition, according to a study by an international research team that includes scientists from the Institute for Biomedical Sciences at Georgia State University.

Chinese researchers uncover link between phase separation and human developmental disorders
Researchers from the Shanghai Institute of Organic Chemistry (SIOC) of the Chinese Academy of Sciences have uncovered the mechanism that underlies the pathogenesis of Noonan syndrome and Noonan syndrome with multiple lentigines.

Likely molecular mechanisms of SARS-CoV-2 pathogenesis are revealed by network biology
Researchers have built an interactome that includes the lung-epithelial cell host interactome integrated with a SARS-CoV-2 interactome.

Decreased protein degradation in cerebellum leads to motor dysfunction
A research team from Kumamoto University, Japan has developed an animal model that reproduces motor dysfunction and cerebellar neurodegeneration similar to that in spinocerebellar ataxia (SCA) by inhibiting chaperone-mediated autophagy (CMA) in cerebellar neurons.

Adding another dimension to a cell culture model for pulmonary arterial hypertension
Pulmonary arterial hypertension is a rare disease in which excessive proliferation of the cells of pulmonary arterial walls obstructs the blood flow in the lungs.

Key signaling pathway in the pathogenesis of Paget's disease identified
Researchers from the University of California, Irvine, in collaboration with their colleagues from Beijing, China, have gained new insights into the development of malignant skin cancers collectively known as Paget's disease.

Biomedical sciences researchers provide methods to inactivate and safely study SARS-CoV-2
Detailed methods on how to perform research on SARS-CoV-2, the virus that causes COVID-19, including procedures that effectively inactivate the virus to enable safe study of infected cells have been identified by virologists in the Institute for Biomedical Sciences at Georgia State University.

Serum irisin: Pathogenesis and clinical research in cardiovascular diseases
In a new publication from Cardiovascular Innovations and Applications; Lutfu Askin, Kader Eliz Uzel, Okan Tanriverdi and Serdar Turkmen from the Department of Cardiology, Adiyaman Education and Research Hospital, Adiyaman, Turkey consider serum irisin pathogenesis and clinical research in cardiovascular diseases.

Read More: Pathogenesis News and Pathogenesis Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.