Houshiheisan maintains stabilization of the internal environment of neurovascular units

July 07, 2014

Cerebral ischemia not only injuries neurons, but also involves the glial cells that provide a supportive scaffold to which the neurons are attached and the microvessels that provide energy for nervous tissue. Therefore, protection of a single neuron is not sufficient to recover nervous function, and more attention should be paid to maintenance of the function of entire neurovascular units. Houshiheisan compound is one of effective traditional Chinese compound prescriptions for stroke. The prescription is composed of wind-dispelling (chrysanthemun flower, divaricate saposhnikovia root, Manchurian wild ginger, cassia twig, Szechwan lovage rhizome, and platycodon root) and deficiency-nourishing (ginseng, Chinese angelica, large-head atractylodes rhizome, Indian bread, and zingiber) drugs. Haizheng Wang and his team, School of Traditional Chinese Medicine, Capital Medical University in China, performed a study on Houshiheisan and found that the wind-dispelling and deficiency-nourishing drugs in the compound prescription Houshiheisan are complementary to each other, effectively suppress abnormal amyloid precursor protein accumulation, reduce amyloid substance deposition, maintain stabilization of the internal environment of neurovascular units, and minimize injury to neurovascular units in the ischemic penumbra by downregulating the amyloid-βexpression. Their findings were published in Neural Regeneration Research (Vol. 9, No. 7, 2014).

Hematoxylin-eosin staining revealed that after intragastric administration of Houshiheisan, the number of nerve cells was visibly increased and there was infiltration of a small number of inflammatory cells in the ischemic penumbra of rats with cerebral ischemia.
Article: " Houshiheisan compound prescription protects neurovascular units after cerebral ischemia," by Haizheng Wang, Lei Wang, Nan Zhang, Qi Zhang, Hui Zhao, Qiuxia Zhang (School of Traditional Chinese Medicine, Capital Medical University, Beijing, China)

Wang HZ, Wang L, Zhang N, Zhang Q, Zhao H, Zhang QX. Houshiheisan compound prescription protects neurovascular units after cerebral ischemia. Neural Regen Res. 2014;9(7):741-748.


Meng Zhao
Neural Regeneration Research

Neural Regeneration Research

Related Neurons Articles from Brightsurf:

Paying attention to the neurons behind our alertness
The neurons of layer 6 - the deepest layer of the cortex - were examined by researchers from the Okinawa Institute of Science and Technology Graduate University to uncover how they react to sensory stimulation in different behavioral states.

Trying to listen to the signal from neurons
Toyohashi University of Technology has developed a coaxial cable-inspired needle-electrode.

A mechanical way to stimulate neurons
Magnetic nanodiscs can be activated by an external magnetic field, providing a research tool for studying neural responses.

Extraordinary regeneration of neurons in zebrafish
Biologists from the University of Bayreuth have discovered a uniquely rapid form of regeneration in injured neurons and their function in the central nervous system of zebrafish.

Dopamine neurons mull over your options
Researchers at the University of Tsukuba have found that dopamine neurons in the brain can represent the decision-making process when making economic choices.

Neurons thrive even when malnourished
When animal, insect or human embryos grow in a malnourished environment, their developing nervous systems get first pick of any available nutrients so that new neurons can be made.

The first 3D map of the heart's neurons
An interdisciplinary research team establishes a new technological pipeline to build a 3D map of the neurons in the heart, revealing foundational insight into their role in heart attacks and other cardiac conditions.

Mapping the neurons of the rat heart in 3D
A team of researchers has developed a virtual 3D heart, digitally showcasing the heart's unique network of neurons for the first time.

How to put neurons into cages
Football-shaped microscale cages have been created using special laser technologies.

A molecule that directs neurons
A research team coordinated by the University of Trento studied a mass of brain cells, the habenula, linked to disorders like autism, schizophrenia and depression.

Read More: Neurons News and Neurons Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.