Nav: Home

Researchers survey immune molecules found inside mycetoma lesions

July 11, 2019

Mycetoma is a common neglected disease caused by either fungi or bacteria which organize themselves into grains--areas of inflammation surrounded by a collagen capsule. Now, researchers reporting in PLOS Neglected Tropical Diseases have studied two immune molecules inside these grains and discovered patterns to where the molecules appear.

Mycetoma is caused by any of 56 different microorganisms and is endemic to many tropical and subtropical areas. It usually affects young adults and children and is most common in farmers and other workers who deal directly with soil. Mycetoma appears as a slow-growing tumor-like mass that gradually increases in size. Previous research has revealed that there are three zones of inflammatory cells surrounding mycetoma grains. However, the immunopathological mechanisms involved in the chronic inflammation of mycetoma have not been well understood.

In the new work, Ahmed Hassan Fahal of the University of Khartoum, Sudan, and colleagues studied surgical biopsies from 100 patients with confirmed mycetoma. They measured expression levels of two immune proteins--interleukin-17 (IL-17) and matrix metalloprotein-9 (MMP-9)--in cells from each zone in the mycetoma grains.

While IL-17 was mostly found in Zones I and II of the grains, MMP-9 was present primarily in the more outer Zones II and III. Levels of the two immune molecules corresponded with each other, and were associated with the disease duration and lesion size. Moreover, levels of MMP-9 also varied by the causative agent of mycetoma. In experiments in mice, animals deficient in IL-17 , granuloma formation was impaired, suggesting an importance of the molecule in early infection.

"The observations presented here are the first step and indicate that IL-17A and MMP-9 are present within the grain," the researchers say. "The functions of IL-17A and MMP-9 in the formation of the grain will be studied in future studies."
-end-
Citation: Siddig EE, Mohammed Edris AM, Bakhiet SM, van de Sande WWJ, Fahal AH (2019) Interleukin-17 and matrix metalloprotease-9 expression in the mycetoma granuloma. PLOS Neglected Tropical Diseases 13(7): e0007351. https://doi.org/10.1371/journal.pntd.0007351

Funding: The authors received no specific funding for this work

Competing Interests: The authors have declared that no competing interests exist.

In your coverage please use this URL to provide access to the freely available paper: http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007351.

PLOS

Related Molecules Articles:

Discovery of periodic tables for molecules
Scientists at Tokyo Institute of Technology (Tokyo Tech) develop tables similar to the periodic table of elements but for molecules.
New method for imaging biological molecules
Researchers at Karolinska Institutet in Sweden have, together with colleagues from Aalto University in Finland, developed a new method for creating images of molecules in cells or tissue samples.
How two water molecules dance together
Researchers have gained new insights into how water molecules interact.
Hand-knitted molecules
Molecules are usually formed in reaction vessels or laboratory flasks.
How molecules teeter in a laser field
When molecules interact with the oscillating field of a laser, an instantaneous, time-dependent dipole is induced.
More Molecules News and Molecules Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Rethinking Anger
Anger is universal and complex: it can be quiet, festering, justified, vengeful, and destructive. This hour, TED speakers explore the many sides of anger, why we need it, and who's allowed to feel it. Guests include psychologists Ryan Martin and Russell Kolts, writer Soraya Chemaly, former talk radio host Lisa Fritsch, and business professor Dan Moshavi.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...