Nav: Home

These days fecal transplantation is no joke

July 12, 2016

NASHVILLE, Tenn. - These days fecal transplantation is no joke.

Fecal transplants are increasingly being used as the treatment of last resort for certain infections in the human gut and have had remarkable success treating the nursing home and hospital-acquired scourge, Clostridium difficile colitis, an infectious diarrhea that often follows antibiotic treatment. There is also preliminary evidence that the transplantation of stool from healthy individuals can be effective in treating multiple sclerosis and Crohn's disease.

At the same time, there has been a major increase in animal experiments involving fecal material. In one study, for example, researchers found that fecal transplants from lean mice turned sterile mice into lean mice, while fecal transplants from fat mice turned sterile mice into fat mice.

"This research is just getting started. It is driven by the new paradigm of the microbiome which recognizes that every plant and animal species harbors a collection of microbes that have significant and previously unrecognized effects on their host health, evolution and behavior," said Seth Bordenstein, associate professor of biological sciences and pathology, microbiology, and immunology at Vanderbilt University.

In an article titled "Fecal Transplants: What is Being Transferred" published July 12 in the journal PLOS Biology, Bordenstein reviews the growing scientific literature on the subject.

"There is no doubt that poo can save lives," said Bordenstein. Take the case of the use of fecal transplants to treat Clostridium difficile infections. According to the literature, it has a 95 percent cure rate. "Right now fecal transplants are used as the treatment of last resort, but their effectiveness raises an important question: When will doctors start prescribing them, or some derivative, first?" Bordenstein asked.

It turns out fecal transplantation has a long history in Chinese medicine. An early-recorded application in humans was in the 4th century by a Chinese medical doctor named Ge Hong. In the 16th century, it was popular enough to get the nickname "yellow soup."

Interest among Western scientific circles was minimal until the year 2010, with fewer than 10 articles on the subject appearing per year in PubMed, an index of biomedical literature. Starting in 2011, however, the number began an exponential rise with more than 200 papers on fecal transplantation appearing in 2015, a trend that shows no sign of slacking.

So far most of the research has been focused on the role of the bacteria in donor's stool. Bacteria are the most abundant active agent in the material. However, they are not the only functional player in feces, Bordenstein cautioned. "Feces is a complex material that contains a variety of biological and chemical entities that may be causing or assisting the effects of these transplants."

Healthy human stool contains on average 100 billion bacteria per gram. But it also contains 100 million viruses and archaea per gram. (Archaea are an understudied domain of single-celled organisms that were classed as bacteria until the 1970's). In addition, there are about 10 million colonocytes (human epithelial cells that help protect the colon) and a million yeasts and other single-celled fungi per gram.

According to Bordenstein, focus on the bacterial component appears to make sense in some cases, such as the treatment of Clostridium difficile colitis, but in other cases, such as the possible treatment of multiple sclerosis, it is quite possible that the effects of fecal transplants may be influenced by, or possibly even caused by, their non-bacterial constituents. As a result, he calls for increased research designed to separate out the effects and interactions of each of these components.

"When scientists identify the specific cocktails that produce the positive outcomes, then they can synthesize or grow them and put them in a pill. That will go a long way to reducing the 'icky factor' that could slow public acceptance of this new form of treatment," said Bordenstein.
-end-
This work was supported by National Science Foundation grants DEB 1046149 and IOS 1456778.

Visit Research News @ Vanderbilt for more research news from Vanderbilt.

Vanderbilt University

Related Bacteria Articles:

Bacteria might help other bacteria to tolerate antibiotics better
A new paper by the Dynamical Systems Biology lab at UPF shows that the response by bacteria to antibiotics may depend on other species of bacteria they live with, in such a way that some bacteria may make others more tolerant to antibiotics.
Two-faced bacteria
The gut microbiome, which is a collection of numerous beneficial bacteria species, is key to our overall well-being and good health.
Microcensus in bacteria
Bacillus subtilis can determine proportions of different groups within a mixed population.
Right beneath the skin we all have the same bacteria
In the dermis skin layer, the same bacteria are found across age and gender.
Bacteria must be 'stressed out' to divide
Bacterial cell division is controlled by both enzymatic activity and mechanical forces, which work together to control its timing and location, a new study from EPFL finds.
How bees live with bacteria
More than 90 percent of all bee species are not organized in colonies, but fight their way through life alone.
The bacteria building your baby
Australian researchers have laid to rest a longstanding controversy: is the womb sterile?
Hopping bacteria
Scientists have long known that key models of bacterial movement in real-world conditions are flawed.
Bacteria uses viral weapon against other bacteria
Bacterial cells use both a virus -- traditionally thought to be an enemy -- and a prehistoric viral protein to kill other bacteria that competes with it for food according to an international team of researchers who believe this has potential implications for future infectious disease treatment.
Drug diversity in bacteria
Bacteria produce a cocktail of various bioactive natural products in order to survive in hostile environments with competing (micro)organisms.
More Bacteria News and Bacteria Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Climate Mindset
In the past few months, human beings have come together to fight a global threat. This hour, TED speakers explore how our response can be the catalyst to fight another global crisis: climate change. Guests include political strategist Tom Rivett-Carnac, diplomat Christiana Figueres, climate justice activist Xiye Bastida, and writer, illustrator, and artist Oliver Jeffers.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Speedy Beet
There are few musical moments more well-worn than the first four notes of Beethoven's Fifth Symphony. But in this short, we find out that Beethoven might have made a last-ditch effort to keep his music from ever feeling familiar, to keep pushing his listeners to a kind of psychological limit. Big thanks to our Brooklyn Philharmonic musicians: Deborah Buck and Suzy Perelman on violin, Arash Amini on cello, and Ah Ling Neu on viola. And check out The First Four Notes, Matthew Guerrieri's book on Beethoven's Fifth. Support Radiolab today at Radiolab.org/donate.