Nav: Home

Pre-stroke risk factors influence long-term future stroke, dementia risk

July 14, 2016

DALLAS, July 14, 2016 -- If you had heart disease risk factors, such as high blood pressure, before your first stroke, your risk of suffering subsequent strokes and dementia up to five years later may be higher, according to new research in the American Heart Association's journal Stroke.

"We already know that stroke patients have an increased risk of recurrent stroke and dementia. What we didn't know was whether this increased risk persists for a long time after stroke and whether heart disease risk factors present before the first stroke influenced the risk of recurrent strokes or dementia," said M. Arfan Ikram, M.D., Ph.D., senior study author and associate professor, department of epidemiology, neurology and radiology, Erasmus University Medical Center in Rotterdam, the Netherlands. "Our study found these risk factors influence future stroke and dementia and the risks persist for an extended period in some patients."

Researchers studied a group of 1,237 stroke survivors from an existing long-term study and compared them to a stroke-free group of about 5,000 people from the same study.

They found:
  • One year after suffering a stroke, survivors retain a high risk of a recurrent stroke or dementia for at least five years.
  • After one year, first-time stroke survivors were three times more likely than those who hadn't suffered a stroke to have a recurrent stroke.
  • Stroke survivors were nearly two times more likely to have dementia than those who had not suffered stroke.
  • Among the stroke survivors, 39 percent of recurrent strokes and 10 percent of post-stroke dementia cases were attributed to pre-stroke cardiovascular risk factors, including high blood pressure; diabetes; low levels of high-density lipoprotein (HDL - the good cholesterol); smoking; and transient ischemic attack (TIA - mini stroke).
"This study suggests that risk factors that lead to the initial stroke may also predispose patients to worsening mental and physical health after stroke. This also applies to risk of death after stroke. We found in a previous study that 27 percent of all deaths after stroke can be attributed to risk factors already present before stroke," Ikram said.

Taking good care of your cardiovascular risk factors -- even if you have never experienced a stroke -- is not only important to prevent the first stroke, but it can go a long way to prevent a second stroke and dementia, he added.

Stroke is the fifth most common cause of death and a leading cause of disability in the United States. The American Heart Association's Life's Simple 7 helps people monitor and reduce cardiovascular risk factors that can lead to heart disease and stroke.
-end-
Co-authors are Marileen L.P. Portegies, M.D.; Frank J. Wolters, M.D.; Albert Hofman, M.D.; M. Kamran Ikram, M.D.; and Peter J. Koudstaal, M.D. Author disclosures are on the manuscript.

The Netherlands Heart Foundation and Erasmus MC Fellowship 2013 funded the study.

Additional Resources:

Researcher photo, brain health infographic, and stroke images are located in the right column of this release link http://newsroom.heart.org/news/pre-stroke-risk-factors-influence-long-term-future-stroke-dementia-risk?preview=756359c7cb55a885095a698e3c0dd719
After July 21, view the manuscript online. http://www.StrokeAssociation.org/brainhealth
Spot a stroke F.A.S.T.
Heart disease risk factors
Physical activity reduces risk of dementia in elderly
Follow AHA/ASA news on Twitter @HeartNews.
For stroke science, follow the Stroke journal at @StrokeAHA_ASA

Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association's policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at http://www.heart.org/corporatefunding.

American Heart Association

Related Heart Disease Articles:

Where you live could determine risk of heart attack, stroke or dying of heart disease
People living in parts of Ontario with better access to preventive health care had lower rates of cardiac events compared to residents of regions with less access, found a new study published in CMAJ (Canadian Medical Association Journal).
Older adults with heart disease can become more independent and heart healthy with physical activity
Improving physical function among older adults with heart disease helps heart health and even the oldest have a better quality of life and greater independence.
Dietary factors associated with substantial proportion of deaths from heart disease, stroke, and disease
Nearly half of all deaths due to heart disease, stroke, and type 2 diabetes in the US in 2012 were associated with suboptimal consumption of certain dietary factors, according to a study appearing in the March 7 issue of JAMA.
Certain heart fat associated with higher risk of heart disease in postmenopausal women
For the first time, researchers have pinpointed a type of heart fat, linked it to a risk factor for heart disease and shown that menopausal status and estrogen levels are critical modifying factors of its associated risk in women.
Maternal chronic disease linked to higher rates of congenital heart disease in babies
Pregnant women with congenital heart defects or type 2 diabetes have a higher risk of giving birth to babies with severe congenital heart disease and should be monitored closely in the prenatal period, according to a study published in CMAJ.
Novel heart valve replacement offers hope for thousands with rheumatic heart disease
A novel heart valve replacement method is revealed today that offers hope for the thousands of patients with rheumatic heart disease who need the procedure each year.
Younger heart attack survivors may face premature heart disease death
For patients age 50 and younger, the risk of premature death after a heart attack has dropped significantly, but their risk is still almost twice as high when compared to the general population, largely due to heart disease and other smoking-related diseases The risk of heart attack can be greatly reduced by quitting smoking, exercising and following a healthy diet.
Citrus fruits could help prevent obesity-related heart disease, liver disease, diabetes
Oranges and other citrus fruits are good for you -- they contain plenty of vitamins and substances, such as antioxidants, that can help keep you healthy.
Gallstone disease may increase heart disease risk
A history of gallstone disease was linked to a 23 percent increased risk of developing coronary heart disease.
Americans are getting heart-healthier: Coronary heart disease decreasing in the US
Coronary heart disease is one of the leading causes of death in the United States.

Related Heart Disease Reading:

Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 2-Volume Set
by Douglas P. Zipes MD (Author), Peter Libby MD PhD (Author), Robert O. Bonow MD MS (Author), Douglas L. Mann MD (Author), Gordon F. Tomaselli MD (Author)

Pathophysiology of Heart Disease: A Collaborative Project of Medical Students and Faculty
by Leonard S. Lilly MD (Author)

Prevent and Reverse Heart Disease: The Revolutionary, Scientifically Proven, Nutrition-Based Cure
by Caldwell B. Esselstyn Jr. (Author)

The Prevent and Reverse Heart Disease Cookbook: Over 125 Delicious, Life-Changing, Plant-Based Recipes
by Ann Crile Esselstyn (Author), Jane Esselstyn (Author)

Illustrated Field Guide to Congenital Heart Disease and Repair - Pocket Sized
by Allen D. Everett (Author), D. Scott, M.D. Lim (Author), Paul Burns (Illustrator), Jasper Burns (Illustrator), Marcia L. Buck (Illustrator), Jane E., M.D. Crosson (Illustrator)

The End of Heart Disease: The Eat to Live Plan to Prevent and Reverse Heart Disease
by Joel Fuhrman M.D. (Author)

Moss & Adams’ Heart Disease in Infants, Children, and Adolescents, Including the Fetus and Young Adult (2 Volume Set)
by Hugh D. Allen MD FACC FAAP FAHA (Author)

The Simple Heart Cure: The 90-Day Program to Stop and Reverse Heart Disease
by Chauncey Crandall (Author)

A Woman's Guide to Living with Heart Disease
by Carolyn Thomas (Author), Martha Gulati (Foreword)

Critical Heart Disease in Infants and Children
by Ross M. Ungerleider MD (Author), Kristen Nelson (Author), David S Cooper (Author), Jon Meliones (Author), Jeffrey Jacobs (Author)

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Approaching With Kindness
We often forget to say the words "thank you." But can those two words change how you — and those around you — look at the world? This hour, TED speakers on the power of gratitude and appreciation. Guests include author AJ Jacobs, author and former baseball player Mike Robbins, Dr. Laura Trice, Professor of Management Christine Porath, and former Danish politician Özlem Cekic.
Now Playing: Science for the People

#509 Anisogamy: The Beginning of Male and Female
This week we discuss how the sperm and egg came to be, and how a difference of reproductive interest has led to sexual conflict in bed bugs. We'll be speaking with Dr. Geoff Parker, an evolutionary biologist credited with developing a theory to explain the evolution of two sexes, about anisogamy, sexual reproduction through the fusion of two different gametes: the egg and the sperm. Then we'll speak with Dr. Roberto Pereira, research scientist in urban entomology at the University of Florida, about traumatic insemination in bed bugs.