Study links restless legs syndrome to poor sleep quality, impaired function in pregnancy

July 14, 2017

DARIEN, IL - July 14, 2017 - A new study of pregnant women shows that restless legs syndrome (RLS) is common and is strongly associated with poor sleep quality, excessive daytime sleepiness, and poor daytime function, which are frequent complaints during pregnancy.

Results show that 36 percent of women in their third trimester had RLS, and half of the women with RLS had moderate to severe symptoms. Compared with pregnant women without RLS, those with RLS were twice as likely to report poor sleep quality and poor daytime function, and they were also more likely to have excessive daytime sleepiness. Additionally, the study found a positive dose-response relationship between RLS severity and the sleep-wake disturbances.

"While we expected that RLS would be relatively common in pregnant women, we were surprised to observe just how many had a severe form," said lead author Galit Levi Dunietz, PhD, a T32 post-doctoral research fellow at the University of Michigan Sleep Disorders Center in Ann Arbor. "These women experienced RLS symptoms at least four times per week."

Study results are published in the July 15 issue of the Journal of Clinical Sleep Medicine.

The study involved 1,563 pregnant women with an average age of 30 years, each of whom was in her third trimester. RLS was diagnosed using the standardized criteria of self-reported symptoms and frequency. Demographic and pregnancy data were extracted from medical records, and sleep information was collected with questionnaires. The study found no evidence for any association between RLS and delivery outcomes.

According to the authors, health care providers often dismiss patient complaints of poor sleep and daytime sleepiness during pregnancy.

"These sleep-wake disturbances are considered common symptoms in pregnancy and are frequently attributed to physiological changes that occur in normal pregnancy, but our data suggest that RLS is an additional contributor to these symptoms," said Dunietz.

The authors suggest that the identification and treatment of RLS in pregnancy - using non-pharmacological approaches - may alleviate the burden of these symptoms for many women.
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This study was partially supported by a T32 Grant from the National Institute of Neurological Disorders and Stroke (NIH/NINDS T32 NS007222) and by the Gene and Tubie Gilmore Fund for Sleep Research, the University of Michigan Institute for Clinical and Health Research (MICHR) grant UL1TR000433, MICHR seed pilot grant F021024, and the National Heart, Lung, and Blood Institute (R21 HL089918).

For a copy of the study, "Restless Legs Syndrome and Sleep-Wake Disturbances in Pregnancy," or the commentary, "Shaking Up Perspectives of Restless Legs Syndrome in Pregnancy," or to arrange an interview with the study author or an AASM spokesperson, please contact AASM Communications Coordinator Corinne Lederhouse at 630-737-9700, ext. 9366, or clederhouse@aasmnet.org.

The monthly, peer-reviewed Journal of Clinical Sleep Medicine is the official publication of the American Academy of Sleep Medicine, a professional membership society that improves sleep health and promotes high quality, patient-centered care through advocacy, education, strategic research, and practice standards. The AASM encourages patients to talk to their doctor about sleep problems and visit http://sleepeducation.org/ for more information about sleep, including a searchable directory of AASM-accredited sleep centers.

American Academy of Sleep Medicine

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