Age-related changes in lateral ventricular width and periventricular white matter by DTI

July 15, 2014

Ventricular enlargement has been suggested as a structural biomarker for normal aging and progression of some illnesses, such as Alzheimer's disease. However, the question of how this structural change in the brain in normal elderly affects change of white matters remains a topic of interest and concern. Dr. Sang Seok Yeo, College of Medicine, Yeungnam University, Republic of Korea, and his team performed a diffusion tensor imaging (DTI) study to investigate the question. They detected four regions of interest in the periventricular white matter of 60 normal subjected aged 20-78 years using DTI technique: the anterior corona radiata, the posterior corona radiata, and the genu and splenium of the corpus callosum. They also assessed ventricular width using ventricular body index, anterior horn index, and posterior horn index, and found that the increase of fractional anisotropy value and apparent diffusion coefficient value of the anterior and posterior corona radiata appear to be related to enlargement of the ventricle by normal aging. Consequently, these effects on periventricular white matter might show correlation with cognitive and sensory motor deficits by aging. These results were published in Neural Regeneration Research (Vol. 9, No. 9, 2014).
Article: " Age-related changes of lateral ventricular width and periventricular white matter in the human brain: a diffusion tensor imaging study" by Yong Hyun Kwon1, Sung Ho Jang2, Sang Seok Yeo3 (1 Department of Physical Therapy, Yeungnam University College, Namgu, Daegu, Republic of Korea; 2 Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Namgu, Daegu, Republic of Korea; 3 Department of Physical Therapy, College of Health Sciences, Dankook University, Dongnam-gu, Cheonan-si, Chungnam, Republic of Korea)

Kwon YH, Jang SH, Yeo SS. Age-related changes of lateral ventricular width and periventricular white matter in the human brain: a diffusion tensor imaging study. Neural Regen Res. 2014;9(9):986-989.

Contact: Meng Zhao
Neural Regeneration Research

Neural Regeneration Research

Related Aging Articles from Brightsurf:

Surprises in 'active' aging
Aging is a process that affects not only living beings.

Aging-US: 'From Causes of Aging to Death from COVID-19' by Mikhail V. Blagosklonny
Aging-US recently published ''From Causes of Aging to Death from COVID-19'' by Blagosklonny et al. which reported that COVID-19 is not deadly early in life, but mortality increases exponentially with age - which is the strongest predictor of mortality.

Understanding the effect of aging on the genome
EPFL scientists have measured the molecular footprint that aging leaves on various mouse and human tissues.

Muscle aging: Stronger for longer
With life expectancy increasing, age-related diseases are also on the rise, including sarcopenia, the loss of muscle mass due to aging.

Aging memories may not be 'worse, 'just 'different'
A study from the Department of Psychological & Brain Sciences in Arts & Sciences adds nuance to the idea that an aging memory is a poor one and finds a potential correlation between the way people process the boundaries of events and episodic memory.

A new biomarker for the aging brain
Researchers at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan have identified changes in the aging brain related to blood circulation.

Scientists invented an aging vaccine
A new way to prevent autoimmune diseases associated with aging like atherosclerosis, Alzheimer's disease, and Parkinson's disease was described in the article.

The first roadmap for ovarian aging
Infertility likely stems from age-related decline of the ovaries, but the molecular mechanisms that lead to this decline have been unclear.

Researchers discover new cause of cell aging
New research from the USC Viterbi School of Engineering could be key to our understanding of how the aging process works.

Deep Aging Clocks: The emergence of AI-based biomarkers of aging and longevity
The advent of deep biomarkers of aging, longevity and mortality presents a range of non-obvious applications.

Read More: Aging News and Aging Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to