Alzheimer's may affect the brain differently in African-Americans than European-Americans

July 15, 2015

MINNEAPOLIS - Alzheimer's disease may cause different changes in the brain, or pathologies, in African-Americans than in white Americans of European descent, according to a study published in the July 15, 2015, online issue of the medical journal of the American Academy of Neurology.

"Because some studies suggest that Alzheimer's disease is more common among older African-Americans than European-Americans, we wanted to see whether the brain changes caused by Alzheimer's are different in these two racial groups," said study author Lisa L. Barnes, PhD, with Rush University Medical Center in Chicago. "Studying how Alzheimer's disease looks in the brain in individuals of different races may help us to further understand the disease and pinpoint strategies for prevention and treatment."

The study included 41 African-Americans with a clinical diagnosis of Alzheimer's dementia from the memory clinic, who had an autopsy of their brain performed after death. They were then compared to 81 deceased European-Americans who had Alzheimer's dementia with the same level of disease severity and were of the same age, sex and education level. Researchers looked for typical signs of Alzheimer's disease (plaques and tangles) as well as other brain changes that can cause dementia, such as infarcts (the brain changes associated with stroke) and Lewy bodies (associated with Lewy body or Parkinson'disease). They noted whether people had just one pathology or more than one. They also looked at small and large blood vessel disease.

Almost all participants in the study had Alzheimer's disease in their brain. Only about half of the European-Americans had pure Alzheimer's disease pathology (no additional pathologies contributing to dementia) whereas the rest had Alzheimer's disease pathology with either infarcts or Lewy bodies. In contrast, less than 25 percent of the African Americans had pure Alzheimer's disease pathology. On the other hand, almost three-quarters (71 percent) of African-Americans had Alzheimer's disease pathology mixed with another type of pathology, compared to 51 percent of European-Americans. Clinical Alzheimer's disease in African-Americans was much more likely to involve pathologies other than Alzheimer's disease pathology. African-Americans also had more frequent and severe blood vessel disease.

"Our study has important clinical implications because it may suggest a need for different types of Alzheimer's prevention and treatments in African-Americans. Indeed, current Alzheimer's drugs primarily target specific Alzheimer pathologies in the brain. Given the mixed pattern of disease that we see in African American brains, it will be important to develop new treatments that target these other common pathologies, particularly for African-Americans," said Barnes.
-end-
The study was supported by the National Institutes of Health and the Illinois Department of Public Health.

To learn more about Alzheimer's disease, please visit http://www.aan.com/patients.

The American Academy of Neurology, an association of more than 28,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer's disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson's disease and epilepsy.

For more information about the American Academy of Neurology, visit http://www.aan.com or find us on Facebook, Twitter, Google+ and YouTube.

Media Contacts:

Rachel Seroka, rseroka@aan.com, (612) 928-6129

Michelle Uher, muher@aan.com, (612) 928-6120

American Academy of Neurology

Related Dementia Articles from Brightsurf:

The danger of Z-drugs for dementia patients
Strong sleeping pills known as 'Z-drugs' are linked with an increased risk of falls, fractures and stroke among people with dementia, according to new research.

The long road to dementia
Alzheimer's disease develops over decades. It begins with a fatal chain reaction in which masses of misfolded beta-amyloid proteins are produced that in the end literally flood the brain.

Why people with dementia go missing
People with dementia are more likely to go missing in areas where road networks are dense, complicated and disordered - according to new research from the University of East Anglia.

PTSD may double risk of dementia
People who have experienced post-traumatic stress disorder (PTSD) are up to twice as likely to develop dementia later in life, according to a new study by UCL researchers, published in the British Journal of Psychiatry.

Dementia education
School-based dementia education could deliver much needed empathy and understanding for older generations as new research from the University of South Australia shows it can significantly improve dementia knowledge and awareness among younger generations.

Building dementia friendly churches
A project to help church communities become more 'dementia friendly' has had a significant impact across the country.

A "feeling" for dementia?
A research team led by the DZNE concludes that personal perception can be an important indicator for the early detection of Alzheimer's disease.

New biomarker for dementia diagnosis
Medical researchers in the UK and Australia have identified a new marker which could support the search for novel preventative and therapeutic treatments for dementia.

Digital solutions for dementia care
Telehealth delivery of dementia care in the home can be as effective as face-to-face home visit services if carers and recipients take advantage of the technologies available, Australian researchers say.

Despite a marked reduction in the prevalence of dementia, the number of people with dementia is set to double by 2050 according to new Alzheimer Europe report
Today, at a European Parliament lunch debate, Alzheimer Europe launched a new report presenting the findings of its collaborative analysis of recent prevalence studies and setting out updated prevalence rates for dementia in Europe.

Read More: Dementia News and Dementia Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.