Enhancement of pancreatic cancer on dynamic CT: Does it correlate with angiogenesis and fibrosis?

July 16, 2009

Prognosis of pancreatic cancer is poor. Recently, it has been clarified that the grade of tumor angiogenesis is a useful prognostic marker in human cancer, including pancreatic cancer. To establish the grade of tumor angiogenesis by non-invasive imaging may be important clinically. However, there are only a few such reports on pancreatic cancer.

The present study, lead by Dr. Hattori and her colleagues from Kanazawa University Graduate School of Medical Science, has recently been published on July 7, 2009 in the World Journal of Gastroenterology. The study investigated the relationship between enhancement on dynamic CT and vascular endothelial growth factor and microvessel density as indicators of angiogenesis, and the extent of fibrosis.

Tumors with strong angiogenesis tended to show high enhancement in the arterial dominant phase. On the other hand, tumors with a larger amount of fibrosis showed a negative correlation with the grade of enhancement during the arterial phase. There was a significant correlation between enhancement on conventional dynamic CT and angiogenesis in pancreatic cancer. However, dynamic CT features that are caused by angiogenesis may be modified by the extent of intratumoral fibrosis.

For the present, anti-angiogenesis agents are still not approved for the treatment of pancreatic cancer. However, as a preliminary investigation for future clinical application, prediction of the grade of angiogenesis by conventional dynamic multidetector CT, which is most often performed for the diagnosis of pancreatic cancer, would be useful clinically.
-end-
Reference: Hattori Y, Gabata T, Matsui O, Mochizuki K, Kitagawa H, Kayahara M, Ohta T, Nakanuma Y. Enhancement patterns of pancreatic adenocarcinoma on conventional dynamic multidetector row CT: Correlation with angiogenesis and fibrosis. World J Gastroenterol 2009; 15(25): 3114-3121

http://www.wjgnet.com/1007-9327/15/3114.asp

Correspondence to: Yuki Hattori, MD, Department ofRadiology, Kanazawa University Graduate School of Medical Science,13-1 Takara-machi, Kanazawa 920-8641,Japan. hattori-ht2ryk@nifty.com Telephone: +81-76-2652323 Fax: +81-76-2344256

World Journal of Gastroenterology

Related Pancreatic Cancer Articles from Brightsurf:

Precision chemo-immunotherapy for pancreatic cancer?
Pancreatic cancer is highly lethal: according to the National Cancer Institute, only about 10 percent of patients remain alive five years after diagnosis.

Nerves keep pancreatic cancer cells from starving
Pancreatic cancer cells avert starvation by signaling to nerves, which grow into dense tumors and secrete nutrients.

Pancreatic cancer: Subtypes with different aggressiveness discovered
To date, no targeted personalized therapies for pancreatic cancer exist.

Bringing the 'sticky' back to pancreatic cancer
A multidisciplinary team of researchers at Japan's Tohoku University has found that a gene regulator, called BACH1, facilitates the spread of pancreatic cancer to other parts of the body.

Does lung damage speed pancreatic cancer?
High levels of CO2 in the body, due to chronic respiratory disorders, may exacerbate pancreatic cancer, making it more aggressive and resistant to therapy.

Scientists have identified the presence of cancer-suppressing cells in pancreatic cancer
Researchers have identified cells containing a protein called Meflin that has a role in restraining the progression of pancreatic cancer.

Pancreatic cancer discovery reveals how the aggressive cancer fuels its growth
A new discovery about pancreatic cancer sheds light on how the cancer fuels its growth and may help explain how promising cancer drugs work -- and for whom they will fail.

Overcoming resistance in pancreatic cancer
In pancreatic cancer cells' struggle to survive, the cells choose alternative routes when their main pathways are blocked by drugs.

Exposing how pancreatic cancer does its dirty work
Pancreatic cancer is a puzzle -- tumors slough off cells into the bloodstream early in the disease, but the tumors themselves have almost no blood vessels in them.

Targeting cell division in pancreatic cancer
Study provides new evidence of synergistic effects of drugs that inhibit cell division and support for further clinical trials.

Read More: Pancreatic Cancer News and Pancreatic Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.