Pioneering student research program leads to international conference

July 17, 2013

(INDIANAPOLIS) Indiana University-Purdue University Indianapolis (IUPUI) will host scientists from around the world next week for the first-ever workshop devoted to Distributed Drug Discovery, an innovative, student-driven research program quickly becoming a high-impact, low-cost teaching model.

Distributed Drug Discovery (D3) combines organic chemical synthesis, computational chemistry and biological evaluation as undergraduates work to develop and test chemical compounds that could be developed into new drugs. Since the program began in 2005, more than 800 compounds have been made and several have been identified as being relevant to drug discovery for neglected diseases, those that may be common in many parts of the world but overlooked by developed countries.

Through D3, students are motivated to solve important humanitarian challenges while also learning to apply interdisciplinary research skills to a project with global implications. It engages beginning students with a research challenge that is scientifically important and socially relevant, said William Scott, Ph.D., a research professor in the Department of Chemistry and Chemical Biology and a former scientist for Indianapolis-based Eli Lilly and Co.

"We believe that Indianapolis, through the success of this program, can become a national and international center linking science education to drug discovery," Scott said.

This research model has gained international attention, leading program coordinators to speaking engagements and site visits in various parts of the world and resulting in the inaugural workshop planned for July 22-26 at IUPUI.

Scott and collaborator Martin O'Donnell, IUPUI Chancellor's Professor in chemistry, say the D3 conference will further promote the program and expand interest and support from the research, education and business communities. Scientists from the National Institutes of Health, Harvard University, Howard University and other U.S. colleges and universities will participate in the conference alongside peers from Kenya, Poland and the Czech Republic.

"We've implemented the D3 program with more than 1,500 IUPUI undergraduates as part of the sophomore organic chemistry lab and 17 undergraduate researchers on a more long-term basis," O'Donnell said.

"Our undergraduates are pushing forward the frontiers of drug discovery while they learn basic research skills and best practices," he added.

D3 students have collaborated on several peer-reviewed, research publications. The model has been piloted at sites in Russia, Spain, Poland and a number of U.S. universities. The conference will allow top-level researchers and educators to influence the growth of the program and expand international collaborations, O'Donnell said.

IUPUI graduates who participated in D3 have gone on to become National Science Foundation (NSF) research fellows and have been accepted at some of the most prestigious M.D. and Ph.D. programs in the country. Professors at a number of schools have secured their own grants based on the incorporation of D3 into their undergraduate educational efforts.

"The cross-disciplinary nature of this program mirrors the needs of the pharmaceutical industry and is a great way to train students to fill jobs that are so important in the effort to treat diseases," Scott said.

D3 currently is funded through an NSF research grant. The program recently expanded into IUPUI biology labs, where compounds created in chemistry labs are being evaluated for antibacterial activity and potential treatment of cystic fibrosis.
-end-
About the School of Science at IUPUI:

The School of Science is committed to excellence in teaching, research and service in the biological, physical, behavioral and mathematical sciences. The School is dedicated to being a leading resource for interdisciplinary research and science education in support of Indiana's effort to expand and diversify its economy. For more information, visit http://www.science.iupui.edu

Indiana University-Purdue University Indianapolis School of Science

Related Education Articles from Brightsurf:

Applying artificial intelligence to science education
A new review published in the Journal of Research in Science Teaching highlights the potential of machine learning--a subset of artificial intelligence--in science education.

Dementia education
School-based dementia education could deliver much needed empathy and understanding for older generations as new research from the University of South Australia shows it can significantly improve dementia knowledge and awareness among younger generations.

How can education researchers support education and public health and institutions during COVID-19?
As education researchers' ongoing work is interrupted by school closures, what can they do to support education and public health institutions dealing with the Covid-19 pandemic?

Online education platforms could scale high-quality STEM education for universities
Online and blended (online and in-person) STEM instruction can produce the same learning outcomes for students as traditional, in-person classes at a fraction of the cost, finds research published today in Science Advances.

Technology in higher education: learning with it instead of from it
Technology has shifted the way that professors teach students in higher education.

The new racial disparity in special education
Racial disparity in special education is growing, and it's more complex than previously thought.

Education may be key to a healthier, wealthier US
A first-of-its-kind study estimate the economic value of education for better health and longevity.

How education may stave off cognitive decline
Prefrontal brain regions linked to higher educational attainment are characterized by increased expression of genes involved in neurotransmission and immunity, finds a study of healthy older adults published in JNeurosci.

Does more education stem political violence?
In a study released online today in Review of Educational Research, a peer-reviewed journal of the American Educational Research Association, three Norwegian researchers attempt to bring clarity to this question by undertaking the first systematic examination of quantitative research on this topic.

Individual education programs not being used as intended in special education
Gone are the days when students with disabilities were placed in a separate classroom, or even in a completely different part of the school.

Read More: Education News and Education Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.