Nav: Home

Link found between bitter-taste sensitivity and cancer risk

July 18, 2018

High bitter-taste sensitivity is associated with a significantly increased risk of cancer in older British women, according to researchers who conducted a unique study of 5,500 women whose diet, lifestyle and health has been tracked for about 20 years.

The research examined the relationship between the ability to taste the bitter-tasting chemical phenylthiocarbamide, known as PTC, or the presence of specific genetic differences in the bitter taste receptor, TAS2R38, which binds to PTC, and risk of cancer in a subset of the UK Women's Cohort Study.

The UK Women's Cohort Study was established in 1995 by nutritional epidemiologists at Leeds University to explore links between diet and chronic disease, cancer in particular. The study had an initial middle-aged female population of 35,000. The researchers obtained cancer incidence data from Great Britain's National Health Service Central Register.

Researchers analyzed the food intake of women in the study, using a 217-item food-frequency questionnaire administered when the women joined the cohort in the late 1990s. Researchers hypothesized that women with higher bitter-taste sensitivity would consume fewer vegetables and have higher incidence of cancer.

Although there was no correlation between bitter-taste sensitivity and vegetable intake, researchers did find that, among older women, bitter-taste sensitivity was associated with greater cancer risk, according to lead researcher Joshua Lambert, associate professor of food science in the College of Agricultural Sciences, Penn State.

Lambert, who collaborated with scientists in Leeds University's nutritional epidemiology group while he was on sabbatical in England conducting the research, noted that depending on the level of sensitivity to bitter tastes, study participants were classified as super-tasters, tasters and non-tasters. The findings were published online this month in the European Journal of Nutrition.

"The difference in cancer incidence between the women with the highest bitter-taste sensitivity and those with the lowest was striking," he said. "Super-tasters had about a 58 percent higher risk of cancer incidence, and the tasters had about a 40 percent higher risk of developing cancer, compared to women who were classified as non-tasters."

However, in this analysis, high bitter-taste sensitivity didn't yield the expected link to dietary choices that could explain the higher cancer incidence, Lambert pointed out.

"Our hypothesis was that women who had higher bitter-taste sensitivity -- either they were PTC tasters or super-tasters, or they had the TAS2R38 diplotype to suggest that they were tasters or super-tasters -- would be at higher risk of developing cancer than women who were non-tasters. We thought that would happen because over their lifetime they would have consumed fewer bitter-tasting vegetables, which have been reported to have cancer preventive activities," he said.

"When we looked at the data, we saw that for women over 60, our hypothesis was partially correct. Cancer risk was higher among women classified as tasters or super-tasters, but we didn't see any differences in bitter-tasting vegetable consumption."

Super-tasters and tasters didn't eat fewer vegetables than the non-tasters, Lambert noted. They reported consuming as many Brussels sprouts and as much broccoli, for instance, as the non-tasters.

So where does that leave researchers? Anxious to do more studies to unravel the factors that drive the relationship between bitter-taste sensitivity and cancer, Lambert said. He and colleagues in Penn State's Department of Food Science and Department of Public Health Sciences submitted a grant application in May to the American Institute for Cancer Research to fund a study on the relationship between bitter-taste sensitivity and colon cancer risk in American men and women.

But it also has them thinking that the relationship between bitter-taste sensitivity and cancer likely relates more to overall diet quality than just vegetable consumption, according to Lambert. He said that more and more, cancer experts suspect that dietary connections to the disease will only be revealed if researchers study the bigger picture.

"Our hypothesis that women with greater bitter-taste sensitivity would eat fewer vegetables, putting them at heightened risk for cancer, was perhaps too narrow a concept," he said. "If you have an aversion to bitter taste, you are also less likely to drink alcohol, and alcohol is a risk factor for cancer. So, do the risks of eating too few vegetables outweigh the benefits of not drinking alcohol in terms of your overall cancer risk, or vice versa? We just don't know, yet."

Although researchers didn't see the relationship between bitter-taste sensitivity and vegetable consumption that they expected, that doesn't mean it doesn't exist in the wider context of the total diet, Lambert suggested.

"Maybe, if we pull back and look at the whole-diet level, we will see that women who are super-tasters have a poorer quality overall diet compared to women who are non-tasters," he said.
-end-
Also involved in the research were: Dr. Janet Cade, Sarah VanDusen and Jennie Cockroft, Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds; Elizabeth Smith, School of Biology, faculty of Biological Sciences, University of Leeds; and Darren Greenwood, Biostatistics Unit, faculty of Medicine and Health, University of Leeds.

The World Cancer Research Fund and the U.S. Department of Agriculture supported this research.

Penn State

Related Cancer Articles:

Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.
Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.
Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.
Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells.
More cancer survivors, fewer cancer specialists point to challenge in meeting care needs
An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made.
New cancer vaccine platform a potential tool for efficacious targeted cancer therapy
Researchers at the University of Helsinki have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment.
American Cancer Society outlines blueprint for cancer control in the 21st century
The American Cancer Society is outlining its vision for cancer control in the decades ahead in a series of articles that forms the basis of a national cancer control plan.
Oncotarget: Cancer pioneer employs physics to approach cancer in last research article
In the cover article of Tuesday's issue of Oncotarget, James Frost, MD, PhD, Kenneth Pienta, MD, and the late Donald Coffey, Ph.D., use a theory of physical and biophysical symmetry to derive a new conceptualization of cancer.
Health indicators for newborns of breast cancer survivors may vary by cancer type
In a study published in the International Journal of Cancer, researchers from the UNC Lineberger Comprehensive Cancer Center analyzed health indicators for children born to young breast cancer survivors in North Carolina.
Few women with history of breast cancer and ovarian cancer take a recommended genetic test
More than 80 percent of women living with a history of breast or ovarian cancer at high-risk of having a gene mutation have never taken the test that can detect it.
More Cancer News and Cancer Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: Reinvention
Change is hard, but it's also an opportunity to discover and reimagine what you thought you knew. From our economy, to music, to even ourselves–this hour TED speakers explore the power of reinvention. Guests include OK Go lead singer Damian Kulash Jr., former college gymnastics coach Valorie Kondos Field, Stockton Mayor Michael Tubbs, and entrepreneur Nick Hanauer.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Dispatch 6: Strange Times
Covid has disrupted the most basic routines of our days and nights. But in the middle of a conversation about how to fight the virus, we find a place impervious to the stalled plans and frenetic demands of the outside world. It's a very different kind of front line, where urgent work means moving slow, and time is marked out in tiny pre-planned steps. Then, on a walk through the woods, we consider how the tempo of our lives affects our minds and discover how the beats of biology shape our bodies. This episode was produced with help from Molly Webster and Tracie Hunte. Support Radiolab today at Radiolab.org/donate.