UMN Medical School researchers explain muscle loss with menopause

July 18, 2019

MINNEAPOLIS, MN- July 18, 2019 - New University of Minnesota Medical School research is the first to show that estrogen is essential to maintaining muscle stem cell health.

In an article recently published in Cell Reports, lead authors Dawn Lowe, PhD, Professor in the Department of Rehabilitation Medicine, Division of Physical Therapy and Rehabilitation Science Graduate Program, University of Minnesota Medical School and Michael Kyba, PhD, Professor of Pediatrics and Carrie Ramey/CCRF Endowed Professor in Pediatric Cancer Research, Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Medical School, are the first to establish that estrogen is essential in females for muscle stem cell maintenance and function.

The study investigates mice whose ovaries were surgically removed as well as mice without the estrogen receptor in their muscle stem cells and evaluated muscles' ability to regenerate. It found that the loss of estrogen or genetic deletion of the estrogen receptor in muscle stem cells led to a 30 to 60 percent drop in muscle stem cell (also known as satellite cell) numbers across five different muscles. The surviving cells had severe difficulty reproducing themselves and generating new muscle after injury. The study also included a collaboration with scientists in Finland who performed muscle biopsies in women shortly before and after the transition to menopause. This showed that in humans, the number of satellite cells correlated strongly with changing serum estrogen levels. "This is the first work to show that estrogen deficiency affects the number as well as the function of satellite cells," said Lowe.

It has been known that estrogen replacement therapy for menopausal symptoms can help maintain muscle health. But such hormone replacement therapy which treats weakening muscles also raises the risk of cancer due to estrogen's effects on tissues, such as those of the breast and endometrium. The team showed that a new class of drug, known to interact with estrogen receptors in a way that doesn't affect breast or endometrial tissue, was able to stimulate the estrogen signal in muscle stem cells and could potentially shield aging women from muscle stem cell decline due to menopause, without the risks associated with conventional hormone replacement therapy.

"It has long been known that male sex hormones promote muscle health, but we have been in the dark about what happens when females age," said Lowe. "What estrogen does in women in terms of reproduction has been known for decades. Now we're learning what estrogens do in women's muscles."
-end-
About the University of Minnesota Medical School

The University of Minnesota Medical School is at the forefront of learning and discovery, transforming medical care and educating the next generation of physicians. Our graduates and faculty produce high-impact biomedical research and advance the practice of medicine. Visit med.umn.edu to learn how the University of Minnesota is innovating all aspects of medicine.

Contact:

Kelly Glynn
Media Relations Coordinator, University of Minnesota Medical School
glynn040@umn.edu
414-758-3191

University of Minnesota Medical School

Related Menopause Articles from Brightsurf:

Cannabis use for menopause symptom management
CLEVELAND, Ohio (September 28, 2020)--As legislation relaxes regarding cannabis, it is being used to manage numerous chronic health conditions and mood symptoms.

Could your menopause symptoms be hard on your heart?
Menopause is accompanied by numerous symptoms that can interfere with a woman's quality of life, but can they also cause health problems?

Research provides new insights into menopause and weight gain
Can women in menopause get the benefits of hormone replacement therapy without the health risks?

Executive function in women post-menopause
Assessing adverse childhood experiences and current anxiety and depression symptoms may help ease cognitive distress in women who have undergone a surgical menopause for cancer risk-reduction, or RRSO, according to a new study published in Menopause.

An apple a day might help keep bothersome menopause symptoms away
A healthy diet rich in fruits and vegetables is known to benefit the human body in so many ways.

Menopause timing hard to determine in every third woman
Is it possible to investigate menopausal age, or not? In more than one in three women aged 50, the body provides no clear answer about the menopause, Swedish study shows.

Having less sex linked to earlier menopause
Women who engage in sexual activity weekly or monthly have a lower risk of entering menopause early relative to those who report having some form of sex less than monthly, according to a new UCL study.

Getting a good night's sleep complicated by menopause
The value of a good night's sleep can't be underestimated.

Early menopause predictor of heart disease
Women who reach menopause before the age of 50 have an increased risk of cardiovascular disease, according to researchers from The University of Queensland.

Microbes are a key marker of vaginal health during menopause
Certain species of bacteria are actually necessary to maintain vaginal health.

Read More: Menopause News and Menopause Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.