Higher kidney function at dialysis start linked with greater risk of death in children

July 18, 2019

HighlightsWashington, DC (July 18, 2019) -- A recent analysis of U.S. data over 2 decades indicates that children with kidney failure are being started on dialysis at higher levels of kidney function. Initiating dialysis at a higher level of kidney function was linked to lower patient survival, however. The findings, which appear in an upcoming issue of JASN, suggest that asymptomatic children with kidney failure may benefit from delaying dialysis.

The optimal treatment for children with chronic kidney failure is kidney transplantation, but most children are treated with dialysis prior to receiving a kidney transplant for various reasons, including to address electrolyte problems, remove excess fluid in the body, and alleviate excessive fatigue. It's unclear whether the timing of dialysis initiation affects patients' long-term health, however.

To investigate, a team led by Elaine Ku, MD, MAS and Erica Winnicki, MD (University of California, San Francisco) analyzed information on children who began dialysis in the United States between 1995 and 2015. The researchers examined patients' level of kidney function at the time of dialysis initiation; they defined higher kidney function as an estimated glomerular filtration rate above 10 ml/min/1.73m2 and lower kidney function as 10 ml/min/1.73m2 or lower. (Kidney failure is defined as an estimated glomerular filtration rate below 15 ml/min/1.73m2).

Of 15,170 children, 4327 (29%) had higher kidney function at dialysis initiation. The risk of death was 1.36 times higher among children with higher kidney function at dialysis initiation. The risk of death was even greater for children with higher kidney function who initiated treatment with hemodialysis rather than peritoneal dialysis.

"We also found that over a 20-year period, children are being started on dialysis with higher kidney function," said Dr. Winnicki. "Understanding why children are being started on dialysis at higher kidney function is important, as concerted efforts to delay dialysis initiation in asymptomatic children could potentially be an avenue for improvement in survival based on these observational findings. In addition, delaying dialysis initiation could allow for more time for living donors to undergo workup for kidney transplantation and shorten the time that children would need to spend on dialysis."

An accompanying editorial noted that increasing rates of children starting dialysis with an estimated glomerular filtration rate above 10 ml/min/1.73m2 over the past 2 decades are concerning given the absence of any benefit. "The direct, immediate, and incontrovertible deleterious financial, psychosocial, and physical impacts of dialysis are experienced on a daily basis by clinicians, children, and their families," the authors wrote.
Study co-authors include Kirsten Johansen, MD, Michael Cabana, MD, Bradley Warady, MD, Charles McCulloch, PhD, and Barbara Grimes PhD, MS.

Disclosures: The authors reported no financial disclosures.

The article, entitled "Higher Estimated Glomerular Filtration Rate at Dialysis Initiation Is Not Associated with a Survival Benefit in Children," will appear online at http://jasn.asnjournals.org/ on July 18, 2019, doi: 10.1681/ASN.2018111130.

The article, entitled "Time's Up! Start Dialysis Later in Children," will appear online at http://jasn.asnjournals.org/ on July 18, 2019.

The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.

Since 1966, ASN has been leading the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients. ASN has more than 20,000 members representing 131 countries. For more information, please visit http://www.asn-online.org or contact the society at 202-640-4660.

American Society of Nephrology

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