Patients resistant to blood pressure treatment do take their drugs

July 19, 2001

Poor compliance with treatment is believed to be the most frequent reason why many patients with high blood pressure (hypertension) do not respond to drug treatment. However, a study in this week's BMJ finds no difference in compliance between treatment resistant and treatment responsive patients.

Researchers at the University Hospital in Basle, Switzerland identified 103 patients with hypertension who had been taking between two and four drugs for at least one month. Using electronic pill boxes that record every opening, they monitored whether patients took their medication over four weeks. (Patients who took 80% or more of their prescribed doses were considered to be compliant).

No difference in compliance was found. Forty (82%) of the 49 treatment resistant patients were compliant, while 46 (85%) of the 54 patients responsive to treatment were compliant.

These findings challenge the common assumption that non-compliance with treatment occurs more in patients not responsive to antihypertensive drugs, say the authors. They suggest that other factors should be examined to explain treatment resistance.
-end-
Contact:
Edouard Battegay, Assistant Professor of Internal Medicine, University Hospital, Basle, Switzerland

Relation between insufficient response to antihypertensive treatment and poor compliance with treatment: a prospective case-control study BMJ Volume 323, pp 142-146

BMJ

Related Hypertension Articles from Brightsurf:

Risk of target organ damage in patients with masked hypertension versus sustained hypertension
In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.1261, Yue Wu, Guoyue Zhang, Rong Hu and Jianlin Du from The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China consider the risk of target organ damage in patients with masked hypertension versus sustained hypertension.

Overactive enzyme causes hereditary hypertension
After more than 40 years, several teams at the MDC and ECRC have now made a breakthrough discovery with the help of two animal models: they have proven that an altered gene encoding the enzyme PDE3A causes an inherited form of high blood pressure.

Diagnosing hypertension in children
Study results call into question the utility of testing blood pressure load--the proportion of elevated blood pressure readings detected over 24 hours--for diagnosing hypertension in children.

When the best treatment for hypertension is to wait
A new study concluded that a physician's decision not to intensify hypertension treatment is often a contextually appropriate choice.

Treatment of hypertension induced albuminuria
Patients with albuminuria will usually need more than one drug to achieve blood pressure control, particularly if the aim is also to reduce albuminuria.

Diagnosing and treating resistant hypertension
Resistant blood pressure affects 12 percent to 15 percent of people currently being treated for high blood pressure.

Dementia can be caused by hypertension
A new study in Cardiovascular Research indicates that patients with high blood pressure are at a higher risk of developing dementia.

Hormone imbalance causes treatment-resistant hypertension
British researchers have discovered a hormone imbalance that explains why it is very difficult to control blood pressure in around 10 per cent of hypertension patients.

Breastfeeding reduces hypertension risk
A study published in the American Journal of Hypertension indicates that women who breastfeed more children, and for longer periods of time, are less likely to suffer from hypertension after they reach menopause.

Lung cancer triggers pulmonary hypertension
Nearly half of all advanced-stage lung cancer patients develop arterial pulmonary hypertension.

Read More: Hypertension News and Hypertension Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.