A genetic variation may increase tuberculosis susceptibility

July 21, 2017

New Rochelle, NY, July 21, 2017-Researchers have shown that a single nucleotide change in a gene that affects production of hepcidin--a peptide involved in inflammation, immunity, and control of iron levels--is associated with greater susceptibility to extrapulmonary tuberculosis. Individuals with this single nucleotide polymorphism (SNP) make significantly less hepcidin in response to infection by Mycobacterium tuberculosis, as reported in Genetic Testing and Molecular Biomarkers, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Genetic Testing and Molecular Biomarkers website until August 18, 2017.

Li Liang, Jun Yue, Li-rong Liu, Min Han, Liu-lin Luo, and Heping Xiao, Tongji University School of Medicine, Shanghai; Huijuan Liu, Chinese Academy of Medical Sciences and Peking Union Medical College, TianJin; and Yan-lin Zhao, Chinese Center for Disease Control and Prevention, Beijing, China, concluded that the SNP in the hepcidin promoter gene may play a critical role in susceptibility to tuberculosis affecting organs other than the lungs, but not pulmonary tuberculosis. The researchers propose that decreased hepcidin production in response to infection and inflammation reduces the ability of macrophages to destroy M. tuberculosis, which then enter the circulation and spread the infection from the lungs to other areas of the body. They present their findings in the article entitled "Association of Single Nucleotide Polymorphism in the Hepcidin Promoter Gene with Susceptibility to Extrapulmonary Tuberculosis."

"This is a potentially important finding in the realm of human susceptibility to infectious disease, which is a greatly under-studied area of research and one that GTMB has chosen to highlight," says Genetic Testing and Molecular Biomarkers Editor-in-Chief Garth D. Ehrlich, PhD, FAAAS, Professor of Microbiology and Immunology, Executive Director, Center for Genomic Sciences and Center for Advanced Microbial Processing, Institute for Molecular Medicine and Infectious Disease, Drexel College of Medicine (Philadelphia, PA).
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About the Journal

Genetic Testing and Molecular Biomarkers is an authoritative peer-reviewed journal published 12 times per year online with open access options and in print that reports on all aspects of genetic testing, including molecular and biochemical based tests and varied clinical situations; ethical, legal, social, and economic aspects of genetic testing; and issues concerning effective genetic counseling. Tables of content and a free sample issue may be viewed on the Genetic Testing and Molecular Biomarkerswebsite.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Human Gene Therapy and OMICS: A Journal of Integrative Biology. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

Mary Ann Liebert, Inc. 140 Huguenot Street, New Rochelle, NY 10801-5215 http://www.liebertpub.com Phone (914) 740-2100 (800) M-LIEBERT Fax (914) 740-2101

Mary Ann Liebert, Inc./Genetic Engineering News

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