University of Pittsburgh study links gynecological complaint to increased risk for herpes

July 22, 2003

PITTSBURGH, July 22 - A recent investigation from the Magee-Womens Research Institute has found an apparent link between a common gynecological disorder called bacterial vaginosis (BV) and an increased risk for the acquisition of herpes. The researchers, who are affiliated with the University of Pittsburgh, report their findings in the August issue of Clinical Infectious Diseases, the journal of the Infectious Diseases Society of America.

"We found that women with BV were nearly twice as likely to get herpes as women who did not have BV," said Thomas L. Cherpes, M.D., a University of Pittsburgh infectious disease fellow and the study's first author. "The presence of BV seems to increase susceptibility to herpes infection in women."

Worldwide, herpes simplex virus type 2 (HSV-2) is one of the most prevalent sexually transmitted diseases. At least 45 million people are estimated to have genital herpes in the United States alone, according to Sharon Hillier, Ph.D., professor in the departments of obstetrics, gynecology and reproductive sciences and molecular genetics and biochemistry at the University of Pittsburgh School of Medicine and senior author of the study. BV also is a frequently diagnosed condition.

"Symptoms of discharge are one of the most common reasons women visit a gynecologist," said Dr. Hillier, adding that BV rates in some populations are estimated as high as 50 percent. "Other studies, too, have shown that women who have BV are more likely to get other sexually transmitted diseases such as gonorrhea and HIV." The Pittsburgh study also noted that risk appeared to be higher among African-American women.

BV is characterized by an increase in vaginal alkalinity and substitution of certain beneficial bacteria, particularly those that produce hydrogen peroxide, with more toxic bacteria. This depletion of hydrogen peroxide-producing bacteria is believed to result in diminished defense against sexually transmitted diseases.

The University of Pittsburgh study involved 1,248 sexually active women 18 to 30 years of age. After initial screening for BV and HSV-2 status, the women were asked to return three more times at four-month intervals for follow-up testing. At each visit, vaginal swabs and blood samples were collected for subsequent evaluation.

Out of the 670 women who were negative for HSV-2 at enrollment, 32 acquired antibodies to HSV-2 during the study period. When adjusted for other variables, it became clear that the presence of BV was a significant indicator of risk for subsequent HSV-2 infection when compared with women who had normal vaginal flora.

"It seems likely that more comprehensive screening and appropriate treatment could reduce susceptibility to HSV-2," said Dr. Hillier.

Unlike HSV-2, which typically has a life-long duration of infection, BV can often be effectively treated with a short course of antibiotics.
Other study authors include Leslie Meyn, M.S.; Marijane Krohn, Ph.D.; and Joel Lurie, B.S., all of the Magee-Womens Research Institute.

Additional contact:
Frank Raczkiewicz
Phone: 412-647-3555
Fax: 412-624-3184

University of Pittsburgh Medical Center

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