Researchers study knee stress at tissue, cellular levels

July 24, 2012

A Cleveland Clinic research team is developing virtual models of human knee joints to better understand how tissues and their individual cells react to heavy loads - virtual models that someday can be used to understand damage mechanisms caused by the aging process or by debilitating diseases, such as osteoarthritis.

Led by Ahmet Erdemir, Ph.D., the team is leveraging the powerful computing systems of the Ohio Supercomputer Center to develop state-of-the-art computational representations of the human body to understand how movement patterns and loads on the joints deform the surrounding tissues and cells. Erdemir is the director of the Computational Biomodeling Core (CoBi) and a faculty member in the Department of Biomedical Engineering at the Lerner Research Institute (LRI) in Cleveland, Ohio.

"The aging process and debilitating diseases affect many aspects of the mechanical function of the human body: from the way we move to how our muscles, joints, tissues, and cells accommodate the loading exerted on the body during daily activities," Erdemir explained. "Computational modeling techniques provide an avenue to obtain additional insights about mechanics at various spatial scales."

Many macro-scale studies have looked at how the various components of a knee joint - cartilage, menisci, ligaments and bone - respond to weight and other external loads. However, Erdemir and colleague Scott C. Sibole wanted to better understand how those large mechanical forces correspond to the related deformation of individual cartilage cells - or chondrocytes - within the knee. Previous micro-scale studies of cartilage have not commonly been based on data from body-level scales, in particular, by the musculoskeletal mechanics of the knee joint.

In addition, calculated deformations typically have been for a single cell at the center of a 100-cubic-micrometer block of simulated tissue; Erdemir used an anatomically based representation that calculated deformations for 11 cells distributed within the same volume.

"In both micro-scale approaches, the cartilage cells experienced amplified deformations compared to those at the macro-scale, predicted by simulating the compression of tissues in the knee joint under the weight of the body," Erdemir found. "In the 11-cell case, all cells experienced less deformation than the single cell case, and also exhibited a larger variance in deformation compared to other cells residing in the same block."

Erdemir's method proved to be highly scalable because of micro-scale model independence that allowed exploitation of distributed memory computing architecture. As a result, Sibole, a research engineer at LRI, was able to leverage the computational muscle of OSC's IBM 1350 Glenn Cluster. At the time, the 9,500 nodes of the Glenn Cluster provided 75 teraflops of computing power, tech-speak for 75 trillion calculations per second. Recently, the Glenn Cluster was partially decommissioned when engineers deployed the center's more powerful HP-Intel Xeon Oakley Cluster.

"Both of OSC's two most recent flagship computing systems were specifically designed to support biomedical applications, such as those employed by Dr. Erdemir and Mr. Sibole," said Ashok Krishnamurthy, OSC interim co-executive director. "Researchers working at Ohio's various respected medical centers are conducting an ever-increasing load of computational studies and analyses, and they now represent a significant share of our user community."
-end-
An article authored by Erdemir and Sibole, "Chondrocyte Deformations as a Function of Tibiofemoral Joint Loading Predicted by a Generalized High-Throughput Pipeline of Multi-Scale Simulations," was recently published in PLoS ONE, an international, peer-reviewed, open-access, online journal. Grant funding from the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health supported the study.

Ohio Supercomputer Center

Related Cartilage Articles from Brightsurf:

Magnetic field and hydrogels could be used to grow new cartilage
Instead of using synthetic materials, Penn Medicine study shows magnets could be used to arrange cells to grow new tissues

Changes in brain cartilage may explain why sleep helps you learn
The morphing structure of the brain's ''cartilage cells'' may regulate how memories change while you snooze, according to new research in eNeuro.

From the lab, the first cartilage-mimicking gel that's strong enough for knees
The thin, slippery layer of cartilage between the bones in the knee is magical stuff: strong enough to withstand a person's weight, but soft and supple enough to cushion the joint against impact, over decades of repeat use.

Little skates could hold the key to cartilage therapy in humans
Unlike humans and other mammals, the skeletons of sharks, skates, and rays are made entirely of cartilage and they continue to grow that cartilage throughout adulthood.

Can magnetic stem cells improve cartilage repair?
Cells equipped with superparamagnetic iron oxide nanoparticles (SPIOs) can be directed to a specific location by an external magnetic field, which is beneficial for tissue repair.

Common conditions keep many patients out of knee cartilage research studies
Issues like age or existing arthritis may preclude patients from participating in clinical studies for new therapies that could benefit them

Will MSC micropellets outperform single cells for cartilage regeneration?
Repair of cartilage injuries or defects is aided by the introduction of mesenchymal stem cells (MSCs), which can be incorporated into hydrogels to amplify their effects.

Exercise helps prevent cartilage damage caused by arthritis
Exercise helps to prevent the degradation of cartilage caused by osteoarthritis, according to a new study from Queen Mary University of London.

Cartilage could be key to safe 'structural batteries'
Your knees and your smartphone battery have some surprisingly similar needs, a University of Michigan professor has discovered, and that new insight has led to a 'structural battery' prototype that incorporates a cartilage-like material to make the batteries highly durable and easy to shape.

Potential arthritis treatment prevents cartilage breakdown
In an advance that could improve the treatment options available for osteoarthritis, MIT engineers have designed a new material that can administer drugs directly to the cartilage.

Read More: Cartilage News and Cartilage Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.