Quercetin alleviates high glucose-induced Schwann cell damage by autophagy

July 25, 2014

It is believed that hyperglycemia leads to increased aldose reductase activity and polyol metabolism in Schwann cells, and the resultant abnormal metabolites cause the organelle's damage and morphological changes such as swelling and vacuolation. Autophagy can remove the damaged organelles, but also provide the materials for cell survival under stressful conditions. Quercetin can reverse high glucose-induced inhibition of neural cell proliferation. Quercetin is also implicated in the mechanism underlying the reduction of apoptosis through autophagy induction. Whether or not quercetin protects Schwann cells through autophagy pathways remains unclear. Dr. Ling Qu and co-workers from Peking Union Medical College Hospital, Peking Union Medical College, China Academy of Medical Sciences, China show that under high glucose conditions, there are fewer autophagosomes in immortalized rat RSC96 cells and primary rat Schwann cells than under control conditions, the proliferative activity of both cell types is signifcantly impaired, and the expression of Beclin-1 and LC3, the molecular markers for autophagy, is significantly lower. After intervention with quercetin, the autophagic and proliferative activity of both cell types is rescued. These results, published in the Neural Regeneration Research (Vol. 9, No. 12, 2014), suggest that quercetin can alleviate high glucose-induced damage to Schwann cells by autophagy.
Article: "Quercetin alleviates high glucose-induced Schwann cell damage by autophagy" by Ling Qu1, Xiaochun Liang1, Bei Gu2, Wei Liu1 (1 Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College, China Academy of Medical Sciences, Beijing, China; 2 Cell Center, Institute of Basic Medical Science, Peking Union Medical College, China Academy of Medical Sciences, Beijing, China) Qu L, Liang XC, Gu B, Liu W. Quercetin alleviates high glucose-induced Schwann cell damage by autophagy. Neural Regen Res. 2014;9(12):1195-1203.

Contact: Meng Zhao
Neural Regeneration Research

Neural Regeneration Research

Related Autophagy Articles from Brightsurf:

Surprising insights into the role of autophagy in neuron
Autophagy protects our neurons in the brain, but for entirely different reasons than previously assumed, as researchers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and Charité in Berlin have shown.

Revealing the identity of the last unknown protein of autophagy
Japanese scientists discovered that Atg9, one of the proteins that function to mediate autophagy, has phospholipid-translocation activity (the lipid scramblase activity) between the two layers of the lipid bilayer?and elucidated that the protein's activity brings about autophagosome membrane expansion.

Lipids, lysosomes, and autophagy: The keys to preventing kidney injury
Lysosomes are cellular waste disposal organelles containing potent enzymes that cause cellular damage if they leak out of ruptured lysosomes.

How zika virus degrades essential protein for neurological development via autophagy
Researchers at the University of Maryland (UMD) shed new light on how Zika virus hijacks our own cellular machinery to break down an essential protein for neurological development, getting it to ''eat itself''.

Autophagy: the beginning of the end
Autophagy, from the Greek for 'self-eating', is an essential process that isolates and recycles cellular components under conditions of stress or when resources are limited.

Cellular cleanup! Atg40 folds the endoplasmic reticulum to facilitate its autophagy
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Institute of Microbial Chemistry investigated 'ER-phagy,' the degradation mechanism of the endoplasmic reticulum (ER), an important organelle with multiple biologically necessary functions like the synthesis of proteins and lipids.

How cells decide the way they want to recycle their content
Researchers from Tokyo Medical and Dental University (TMDU) identified a new phosphorylation site of Ulk1 as a novel regulating mechanism of alternative autophagy.

Autophagy: Scientists discover novel role for self-recycling process in the brain
Proteins classically associated with autophagy regulate the speed of intracellular transport.

Insights into the diagnosis and treatment brain cancer in children
In a recent study published in Autophagy, researchers at Kanazawa University show how abnormalities in a gene called TPR can lead to pediatric brain cancer.

Autophagy degrades liquid droplets, but not aggregates, of proteins
Autophagy is a mechanism through which cellular protein is degraded.

Read More: Autophagy News and Autophagy Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.