Hamburger disease drug put to the test

July 29, 2003

A research study, testing a new treatment for hamburger disease, was launched today at The Montreal Children's Hospital of the McGill University Health Centre (MUHC). The study conducted by investigators from the Research Institute of the MUHC and from The Children's, will test the ability of this treatment to stop disease progression in children.

"Hamburger disease", or hemolytic uremic syndrome (HUS), affects more than 3 000 North Americans annually and is one the leading causes of acute and chronic kidney failure in children. It usually occurs following a gastrointestinal infection caused by a strain of bacteria called E.coli O157:H7. This bacterium has been associated with eating undercooked ground beef and drinking contaminated water, unpasteurized milk, or apple juice. The organism was involved in the Walkerton epidemic several years ago.

"Currently, there is no effective treatment for HUS," says MUHC pediatrician and lead investigator Dr. Paul Goodyer. "Approximately, ten percent of E.coli-infected patients, many of whom are children, develop HUS. About half of the HUS patients require dialysis and even with comprehensive medical care four to five percent of these patients will die. Thirty percent to fifty percent of the survivors will develop long-term complications such as chronic kidney disease and nervous system disorders. Clearly, we need treatment for this disease."

The MUHC is one of six Canadian centres testing this new treatment. The treatment involves administrating an antibody to the toxin produced by E.coli O157:H7. "We expect that this antibody will inactivate the toxin in the bloodstream at an early enough stage to prevent damage to kidneys and brain," says MUHC emergency room physician and co-investigator Dr. Dominic Chalut.

Children seen at the Montreal Children's Hospital Emergency Department who have bloody diarrhea for less than 72 hours and whose stools test positive for E.coli O157:H7 are eligible for the study. Following administration of the treatment, blood and urine samples will be taken and disease progression will be assessed. The children will be followed for a total of four months.
This study is funded by Tejin America Inc.

McGill University

Related Antibody Articles from Brightsurf:

Antibody evolution may predict COVID-19 outcomes
For COVID-19, the difference between surviving and not surviving severe disease may be due to the quality, not the quantity, of the patients' antibody development and response, suggests a new study.

Can an antibody 'cocktail' prevent COVID-19 infection?
In a new COVID-19 clinical trial, Stuart Cohen at UC Davis Health tests monoclonal antibody combination to prevent COVID-19 in adults exposed to infected patients.

An in-depth analysis of antibody responses to SARS-CoV-2
Using a technology called VirScan to study coronavirus antibody responses in a large cohort of SARS-CoV-2-infected and control individuals, researchers identified epitopes recognized by a large fraction of COVID-19 patients, epitopes cross-reactive with antibodies developed in response to other human coronaviruses, and 10 epitopes likely recognized by neutralizing antibodies.

Tracking antibody profiles for influenza exposures across the lifespan
Immune responses to influenza exposures increase early in life, then decline in middle age, according to a study published July 23 in the open-access journal PLOS Pathogens by Bingyi Yang of the University of Florida, Steven Riley of Imperial College London, Derek Cummings of the University of Florida, and colleagues.

New study ranks performance of currently available COVID-19 antibody tests
Conducted by researchers at NSF International and Novateur Ventures, the peer-reviewed study finds significant variability in the accuracy of available COVID-19 antibody tests.

Ushering an antibody cocktail, designed to reduce antibody resistance, to trial as COVID-19 therapy
Following two studies that screened thousands of human antibodies to SARS-CoV-2 to identify highly potent pairs, in which the antibodies bind non-overlapping regions of the viral target, a resultant antibody cocktail is being tested in human trials.

COVID-19 antibody tests: How reliable are they?
With stay-at-home orders expiring around the world, many hope that COVID-19 antibody testing will help businesses and institutions reopen safely.

A faster way to make antibody-drug conjugates
In a study published today in Science Advances, USC scientists describe a new technology to rapidly create a homogeneous type of ADC, which attaches to a specific site on the cancer cell, with improved efficiency and potentially enhanced stability, effectiveness and safety.

Antibody designed to recognize pathogens of Alzheimer's disease
Researchers have found a way to design an antibody that can identify the toxic particles that destroy healthy brain cells -- a potential advance in the fight against Alzheimer's disease.

New technology can detect anti-virus antibody in 20 minutes
Researchers have succeeded in detecting anti-avian influenza virus antibody in blood serum within 20 minutes, using a portable analyzer they have developed to conduct rapid on-site bio tests.

Read More: Antibody News and Antibody Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to