Exercise and PRP promising for shoulder pain in wheelchair users with spinal cord injury

July 29, 2020

East Hanover, NJ. July 29, 2020. Researchers in regenerative rehabilitation conducted a pilot study of a new approach to the treatment of treatment-resistant shoulder pain in wheelchair users with spinal cord injury (SCI) and rotator cuff disease. Results were encouraging in the study of six participants who received a combination of a single injection of platelet-rich plasma (PRP) into the supraspinatus tendon and a home-based exercise program of stretching and strengthening.

The article, "Ultrasound-guided platelet-rich plasma injection for the treatment of recalcitrant rotator cuff disease in wheelchair users with spinal cord injury: A pilot study", (doi: 10.1080/10790268.2020.1754676) was epublished ahead of print on May 7, 2020 by the Journal of Spinal Cord Medicine.

The authors are scientists with expertise in regenerative rehabilitation and SCI rehabilitation: Trevor Dyson-Hudson, MD, and Nathan Hogaboom, PhD, at Kessler Foundation, Reina Nakamura, DO, of the University of Michigan, Alon Terry, MD, of Summit Medical Group, Summit, NJ, and Gerard Malanga, MD, from Kessler Institute for Rehabilitation and the New Jersey Regenerative Institute.

The study was conducted at the Derfner-Lieberman Laboratory for Regenerative Rehabilitation Research in the Center for Spinal Cord Injury Research at Kessler Foundation, both under the direction of Dr. Dyson-Hudson, MD. Dr. Hogaboom is co-director of the Derfner-Lieberman Laboratory.

The objective of the pilot study was to evaluate the safety and treatment effect of PRP injection in wheelchair users with SCI and shoulder pain unresponsive to conservative treatment. Six male participants competed the study (3 paraplegia; 3 tetraplegia). All were wheelchair users with a history of chronic SCI (26.7 year ± 11.1 years) and bilateral shoulder pain (> 6 months).

Treatment consisted of bilateral injection of PRP into the shoulder joints. After a 24-hour rest period, participants started a stretching regimen that transitioned to a strengthening protocol at one-month post injection. Followup was conducted at 4, 8, 12, and 24 weeks, consisting of ultrasound evaluation, physical examination, and assessment of pain level. All participants reported decreased pain, with three describing their pain as 'much improved' and one 'very much improved'. No adverse effects were reported.

In this population, shoulder pain is a common cause of disability that hinders functional independence, according to Dr. Dyson-Hudson, director of the Center for Spinal Cord Research. While surgery is an option for pain that fails to respond to conservative treatment, drawbacks include the costs and the functional limitations during prolonged post-operative recovery.

"Conservative treatments that provide alternatives to surgery are needed for this population," he emphasized. "Injection of PRP, which may promote healing of the injured tendon, combined with a graduated exercise program, is a potential option for these individuals. Based on our pilot study, a larger randomized controlled trial is warranted."
-end-
Funding sources: Derfner Foundation, Kessler Foundation, National Institute on Disability Independent Living and Rehabilitation Research (90SI5011)

About Kessler Foundation.essler Foundation, a major nonprofit organization in the field of disability, is a global leader in rehabilitation research that improves cognition, mobility and long-term outcomes, including employment, for people with neurological disabilities caused by diseases and injuries of the brain and spinal cord. Kessler Foundation leads the nation in funding innovative programs that expand opportunities for employment for people with disabilities. Learn more by visiting http://www.KesslerFoundation.org.

About the Journal of Spinal Cord Medicine

The Journal of Spinal Cord Medicine (JSCM) serves the international community of professionals dedicated to improving the lives of people with injuries/disorders of the spinal cord. JSCM is the peer-reviewed official journal of the Academy of Spinal Cord Injury Professionals (ASCIP), a US-based multidisciplinary organization serving scientists, physicians, psychologists, nurses, therapists and social workers in the field of spinal cord injury care and research. JSCM, a member benefit of ASCIP, is published six times a year by Taylor & Francis Publishing. The editor-in-chief is Dr. Florian Thomas of Hackensack University Medical Center, Meridian School of Medicine, Hackensack, NJ, USA. JSCM's 2019 Impact Factor is 1.816.

Contact: Carolann Murphy, PA, Assistant Editor; Cmurphy@KesslerFoundation.org

Kessler Foundation

Related Spinal Cord Injury Articles from Brightsurf:

Stem cells can help repair spinal cord after injury
Spinal cord injury often leads to permanent functional impairment. In a new study published in the journal Science researchers at Karolinska Institutet in Sweden show that it is possible to stimulate stem cells in the mouse spinal cord to form large amounts of new oligodendrocytes, cells that are essential to the ability of neurons to transmit signals, and thus to help repair the spinal cord after injury.

Spinal cord injury increases risk for mental health disorders
A new study finds adults with traumatic spinal cord injury are at an increased risk of developing mental health disorders and secondary chronic diseases compared to adults without the condition.

Co-delivery of IL-10 and NT-3 to enhance spinal cord injury repair
Spinal cord injury (SCI) creates a complex microenvironment that is not conducive to repair; growth factors are in short supply, whereas factors that inhibit regeneration are plentiful.

IU scientists study link between energy levels, spinal cord injury
A team of researchers from Indiana University School of Medicine, in collaboration with the National Institute of Neurological Disorders and Stroke, have investigated how boosting energy levels within damaged nerve fibers or axons may represent a novel therapeutic direction for axonal regeneration and functional recovery.

UBCO professor simplifies exercise advice for spinal cord injury
Professor Kathleen Martin Ginis says a major barrier to physical activity for people with a spinal cord injury is a lack of knowledge or resources about the amount and type of activity needed to achieve health and fitness benefits.

Robotic trunk support assists those with spinal cord injury
A Columbia Engineering team has invented a robotic device -- the Trunk-Support Trainer (TruST) -- that can be used to assist and train people with spinal cord injuries (SCIs) to sit more stably by improving their trunk control, and thus gain an expanded active sitting workspace without falling over or using their hands to balance.

Does frailty affect outcomes after traumatic spinal cord injury?
A new study has shown that frailty is an important predictor of worse outcome after traumatic spinal cord injury in patients less than 75 years of age.

Sleep and sleepiness 'a huge problem' for people with spinal cord injury
A new study led by a University of Calgary researcher at the Cumming School of Medicine (CSM) finds that fatigue and sleep may need more attention in order to prevent issues like stroke after spinal cord injury.

From spinal cord injury to recovery
Spinal cord injury disconnects communication between the brain and the spinal cord, disrupting control over part of the body.

Transplanting adult spinal cord tissues: A new strategy of repair spinal cord injury
Spinal cord injury repair is one of the most challenging medical problems, and no effective therapeutic methods has been developed.

Read More: Spinal Cord Injury News and Spinal Cord Injury Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.