Gene test could reduce unnecessary treatment for women with breast cancer

July 31, 2003

In this week's issue of THE LANCET, US researchers describe how gene expression profiles could determine whether or not women with breast cancer would respond to docetaxel treatment. Women who are likely to be resistant to the drug could be given alternative treatment.

Chemotherapy or hormonal treatment after surgery for breast cancer is crucial in reducing mortality. Patients react differently to chemotherapy drugs and some women are resistant to treatment. However, since there is currently no way to distinguish between women who might respond and those who probably will not, all eligible patients are treated similarly.

Jenny Chang and colleagues from Baylor College of Medicine, Texas, USA, proposed that gene expression profiles might indicate a patient's response to docetaxel, one of the newest and most widely used chemotherapy drugs. They took biopsy samples from primary breast tumours in 24 patients before treatment, and then measured tumour response to docetaxel.

Different gene expression profiles were associated with different responses to the drug. Tumours that were sensitive to treatment had higher expression of genes involved in the cell cycle, protein transport, and protein modification, whereas resistant tumours showed enhanced expression of some transcriptional and signal transduction genes.

Dr Chang comments: "This study helps to define the molecular portrait of cancers that respond or not to docetaxel, one of the most active agents in breast cancer treatment. When validated, this type of molecular profiling could have important implications in defining the optimum treatment for individual patients, and reduce unproductive treatment, unnecessary toxicity, and overall cost. "
-end-
[See Commentary, page 340]

Contact: Dr Jenny Chang, Breast Center, Baylor College of Medicine and the Methodist Hospital, One Baylor Plaza, BCM 600, Houston, Texas, USA; T) 1-713-798-1905; F) 1-713-798-1642; E)"> jcchang@breastcenter.tmc.edu



Lancet

Related Breast Cancer Articles from Brightsurf:

Oncotarget: IGF2 expression in breast cancer tumors and in breast cancer cells
The Oncotarget authors propose that methylation of DVDMR represents a novel epigenetic biomarker that determines the levels of IGF2 protein expression in breast cancer.

Breast cancer: AI predicts which pre-malignant breast lesions will progress to advanced cancer
New research at Case Western Reserve University in Cleveland, Ohio, could help better determine which patients diagnosed with the pre-malignant breast cancer commonly as stage 0 are likely to progress to invasive breast cancer and therefore might benefit from additional therapy over and above surgery alone.

Partial breast irradiation effective treatment option for low-risk breast cancer
Partial breast irradiation produces similar long-term survival rates and risk for recurrence compared with whole breast irradiation for many women with low-risk, early stage breast cancer, according to new clinical data from a national clinical trial involving researchers from The Ohio State University Comprehensive Cancer Center - Arthur G.

Breast screening linked to 60 per cent lower risk of breast cancer death in first 10 years
Women who take part in breast screening have a significantly greater benefit from treatments than those who are not screened, according to a study of more than 50,000 women.

More clues revealed in link between normal breast changes and invasive breast cancer
A research team, led by investigators from Georgetown Lombardi Comprehensive Cancer Center, details how a natural and dramatic process -- changes in mammary glands to accommodate breastfeeding -- uses a molecular process believed to contribute to survival of pre-malignant breast cells.

Breast tissue tumor suppressor PTEN: A potential Achilles heel for breast cancer cells
A highly collaborative team of researchers at the Medical University of South Carolina and Ohio State University report in Nature Communications that they have identified a novel pathway for connective tissue PTEN in breast cancer cell response to radiotherapy.

Computers equal radiologists in assessing breast density and associated breast cancer risk
Automated breast-density evaluation was just as accurate in predicting women's risk of breast cancer, found and not found by mammography, as subjective evaluation done by radiologists, in a study led by researchers at UC San Francisco and Mayo Clinic.

Blood test can effectively rule out breast cancer, regardless of breast density
A new study published in PLOS ONE demonstrates that Videssa® Breast, a multi-protein biomarker blood test for breast cancer, is unaffected by breast density and can reliably rule out breast cancer in women with both dense and non-dense breast tissue.

Study shows influence of surgeons on likelihood of removal of healthy breast after breast cancer dia
Attending surgeons can have a strong influence on whether a patient undergoes contralateral prophylactic mastectomy after a diagnosis of breast cancer, according to a study published by JAMA Surgery.

Young breast cancer patients undergoing breast conserving surgery see improved prognosis
A new analysis indicates that breast cancer prognoses have improved over time in young women treated with breast conserving surgery.

Read More: Breast Cancer News and Breast Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.