Nav: Home

Weight gain between pregnancies linked to increased risk of gestational diabetes

August 01, 2017

The risk of developing gestational diabetes mellitus (GDM) increases with increased weight gain between pregnancies, according to a new study published in PLOS Medicine by Linn Sorbye of the University of Bergen, Norway, and colleagues.

GDM is defined as glucose intolerance of various degrees that is first detected during pregnancy. Both pre-pregnant body mass index (BMI) and gestational weight gain are known risk factors for GDM, which can cause health problems for both mothers and babies. In the new study, researchers used data from the Medical Birth Registry of Norway on 24,198 mothers with a first and second pregnancy between 2006 and 2014. The data included BMI at the start of each pregnancy as well as any diagnosis of GDM.

The overall absolute risk of GDM in second pregnancy was 18.1 per 1000 pregnancies. 35.6 % of women in the study gained more than 1 BMI unit (kg/m2) of weight between the start of their first pregnancy and the start of their second pregnancy. These women had an increased risk of developing GDM in their second pregnancy compared to women whose weight was stable (-1 to < 1 BMI units). Women who gained between 1 and 2 BMI units had a doubled risk (adjusted risk ratio (aRR) 2.0, 95% confidence interval (CI): 1.5-2.7), women gaining between 2 and 4 units had a 2.6 times increased risk (a RR 2.6, 95%CI: 2.0-3.5), and women gaining ≥4 BMI units had a five-fold increased risk (a RR 5.4, 95% CI: 4.0-7.4). These increased risks were strongest in women who had a BMI below 25 kg/m2 in their first pregnancy. Evidence of a preventive effect on GDM was seen in overweight women (BMI ≥25) who reduced their weight by ≥ 2 BMI units between pregnancies.

"Antenatal guidelines for monitoring GDM in pregnancy should add inter-pregnancy weight change as an independent risk factor for GDM with a routine stress-test of glucose tolerance during pregnancy in women with weight gain more than 1 BMI unit," the authors say.
-end-
-end-
Funding:

This study was funded by a 3-year scholarship from The Norwegian National Advisory Unit on Women's Health at Oslo University Hospital, Rikshospitalet, Norway. The research fellow in this scholarship is the corresponding author LMS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests:

The authors of this manuscript declare no competing interests.

Citation:

Sorbye LM, Skjaerven R, Klungsoyr K, Morken NH (2017) Gestational diabetes mellitus and interpregnancy weight change: A population-based cohort study. PLoS Med 14(8): e1002367. https://doi.org/10.1371/journal.pmed.1002367

Author Affiliations:

Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway

Norwegian National Advisory Unit on Women's Health, Oslo University Hospital, Rikshospitalet, Oslo, Norway

Medical Birth Registry of Norway, Norwegian Institute of Public Health, Bergen, Norway

Department of Clinical Science, University of Bergen, Bergen, Norway

IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER:

http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002367

PLOS

Related Pregnancy Articles:

Paracetamol during pregnancy can inhibit masculinity
Paracetamol during pregnancy can inhibit masculinity Paracetamol during pregnancy can inhibit the development of 'male behavior' in mice.
The cost of opioid use during pregnancy
A new study published today by the scientific journal Addiction reveals that the incidence of neonatal abstinence syndrome -- often caused by mothers using opioids during pregnancy -- is increasing in the United States, and carries an enormous burden in terms of hospital days and costs.
New study: Pre-pregnancy BMI directly linked to excess pregnancy weight gain
It's well known that excessive weight gain during pregnancy can have a lasting negative impact on the health of a mother and her baby.
Pregnancy-specific β1-glycoproteins
Development of new strategies and novel drug design to treat trophoblastic diseases and to provide pregnancy success are of crucial importance in maintenance the female reproductive health.
Should hypothyroidism in pregnancy be treated?
When a woman becomes pregnant, many changes occur in her body.
Pre-pregnancy progesterone helps women with recurrent pregnancy loss
Women who have had two or more unexplained miscarriages can benefit from natural progesterone treatment before pregnancy, a new a study from the University of Illinois at Chicago shows.
Male pipefish pregnancy, it's complicated
In the upside-down world of the pipefish, sexual selection appears to work in reverse, with flashy females battling for males who bear the pregnancy and carry their young to term in their brood pouch.
Pregnancy leads to changes in the mother's brain
A study directed by researchers from the UAB and IMIM are the first to reveal how pregnancy causes long-lasting alterations in brain structure, probably related to improving the mother's ability to protect and interact with the child.
MRIs during pregnancy and outcomes for infants, children
In an analysis that included more than 1.4 million births, exposure to magnetic resonance imaging (MRI) during the first trimester of pregnancy compared with nonexposure was not associated with increased risk of harm to the fetus or in early childhood, although gadolinium MRI at any time during pregnancy was associated with an increased risk of a broad set of rheumatological, inflammatory, or skin conditions and, possibly, for stillbirth or neonatal death, according to a study appearing in the Sept.
The benefits of exercise during pregnancy
Women who exercise during pregnancy are more likely to deliver vaginally than those who do not, and show no greater risk of preterm birth.

Related Pregnancy Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Anthropomorphic
Do animals grieve? Do they have language or consciousness? For a long time, scientists resisted the urge to look for human qualities in animals. This hour, TED speakers explore how that is changing. Guests include biological anthropologist Barbara King, dolphin researcher Denise Herzing, primatologist Frans de Waal, and ecologist Carl Safina.
Now Playing: Science for the People

#SB2 2019 Science Birthday Minisode: Mary Golda Ross
Our second annual Science Birthday is here, and this year we celebrate the wonderful Mary Golda Ross, born 9 August 1908. She died in 2008 at age 99, but left a lasting mark on the science of rocketry and space exploration as an early woman in engineering, and one of the first Native Americans in engineering. Join Rachelle and Bethany for this very special birthday minisode celebrating Mary and her achievements. Thanks to our Patreons who make this show possible! Read more about Mary G. Ross: Interview with Mary Ross on Lash Publications International, by Laurel Sheppard Meet Mary Golda...