Potentially Fatal, But Treatable Lung Disease Thought to Occur Only in Far East Diagnosed in United States

August 01, 1996

Potentially Fatal, But Treatable Lung Disease

Potentially Fatal, But Treatable Lung Disease Thought to Occur Only In Far East Diagnosed in United States

A lung disease thought to affect only people from Japan, China and Korea has been identified in five people in the United States who have never been to the Far East and are not of Asian descent. Panbronchiolitis, diagnosed in its early stages, is stopped easily with long-term use of the antibiotic erythromycin. But the disease causes death in 50 percent of people who have it 5 years after diagnosis if left untreated, according to an article in the August issue of the American Review of Respiratory Disease.

Panbronchiolitis is found most frequently in people living in Japan; fewer than 10 cases have been identified in North America.

"For the past 10 years, panbronchiolitis was diagnosed almost entirely in Asia," explains Talmadge King Jr., M.D., a National Jewish Center for Immunology and Respiratory Medicine physician and a co-author of the study. "We believe that as physicians in the United States become more familiar with this disease there will be a significant surge in identification."

The cause of panbronchiolitis, which inflames bronchioles and surrounding alveoli, is unknown. People with the disease have severely limited air flow. Most people with the disease don't smoke, but almost all have chronic sinusitis. Chronic sinusitis, the inflammation of mucous membranes that line sinus cavities, is present in at least 75 percent of Japanese people diagnosed with panbronchiolitis.

Symptoms include coughing, sputum, recurrent fever, weight loss and a long history of illness, such as chronic sinusitis. More common in men, the disease's 10-year survival rate is 25 percent.

National Jewish Health

Related Disease Articles from Brightsurf:

CLCN6 identified as disease gene for a severe form of lysosomal neurodegenerative disease
A mutation in the CLCN6 gene is associated with a novel, particularly severe neurodegenerative disorder.

Cellular pathway of genetic heart disease similar to neurodegenerative disease
Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure.

Mechanism linking gum disease to heart disease, other inflammatory conditions discovered
The link between periodontal (gum) disease and other inflammatory conditions such as heart disease and diabetes has long been established, but the mechanism behind that association has, until now, remained a mystery.

Potential link for Alzheimer's disease and common brain disease that mimics its symptoms
A new study by investigators from Brigham and Women's Hospital uncovered a group of closely related genes that may capture molecular links between Alzheimer's disease and Limbic-predominant Age-related TDP-43 Encephalopathy, or LATE, a recently recognized common brain disorder that can mimic Alzheimer's symptoms.

Antioxidant agent may prevent chronic kidney disease and Parkinson's disease
Researchers from Osaka University developed a novel dietary silicon-based antioxidant agent with renoprotective and neuroprotective effects.

Tools used to study human disease reveal coral disease risk factors
In a study published in Scientific Reports, a team of international researchers led by University of Hawai'i (UH) at Mānoa postdoctoral fellow Jamie Caldwell used a statistical technique typically employed in human epidemiology to determine the ecological risk factors affecting the prevalence of two coral diseases--growth anomalies, abnormalities like coral tumors, and white syndromes, infectious diseases similar to flesh eating bacteria.

Disease-aggravating mutation found in a mouse model of neonatal mitochondrial disease
The new mitochondrial DNA (mtDNA) variant drastically speeds up the disease progression in a mouse model of GRACILE syndrome.

Human longevity largest study of its kind shows early detection of disease & disease risks
Human Longevity, Inc. (HLI) announced the publication of a ground-breaking study in the journal Proceedings of the National Academy of Sciences (PNAS).

30-year study identifies need of disease-modifying therapies for maple syrup urine disease
A new study analyzes 30 years of patient data and details the clinical course of 184 individuals with genetically diverse forms of Maple Syrup Urine Disease (MSUD), which is among the most volatile and dangerous inherited metabolic disorders.

Long-dormant disease becomes most dominant foliar disease in New York onion crops
Until recently, Stemphylium leaf blight has been considered a minor foliar disease as it has not done much damage in New York since the early 1990s.

Read More: Disease News and Disease Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.