Bacteria-immune system 'fight' can lead to chronic diseases, study suggestsAugust 02, 2012
ATLANTA - Results from a study conducted at Georgia State University suggest that a "fight" between bacteria normally living in the intestines and the immune system, kicked off by another type of bacteria, may be linked to two types of chronic disease.
The study suggests that the "fight" continues after the instigator bacteria have been cleared by the body, according to Andrew Gewirtz, professor of biology at the GSU Center for Inflammation, Immunity and Infection. That fight can result in metabolic syndrome, an important factor in obesity, or inflammatory bowel disease (IBD).
The results were published in the journal Cell Host & Microbe.
"The implication at present is that it is very important to control the early environment," Gewirtz said. "We need to examine how this can be achieved - perhaps via breastfeeding, a more diverse diet, probiotics are possibilities."
The study's results are important as instances of chronic diseases like metabolic syndrome and IBD are increasing rapidly among humans, he explained.
Metabolic syndrome involves risk factors, including obesity, which can lead to cardiovascular disease, diabetes and stroke. According to the American Heart Association, about 35 percent of adults are affected by this syndrome.
IBD, which includes Crohn's disease and ulcerative colitis, happens when the intestines become inflamed, leading to abdominal cramps and pain, diarrhea, weight loss and bleeding.
More than 600,000 Americans annually have some kind of inflammatory bowel disease, according to the American Academy of Family Physicians.
Bacteria normally live in the gut of humans, with the average human having about 4 pounds of bacteria living there.
"It is increasingly apparent that bacteria are playing a role in healthy development, and need to be properly managed by the mucosal immune system to avoid inflammatory diseases" Gewirtz explained.
Participating institutions included GSU's Center for Inflammation, Immunity and Infection and the Department of Biology; Clermont University of the Universite d'Auvergne in France; Insern; the Department of Microbiology of Cornell University; the Department of Medical Biochemistry of the University of Gothenberg in Sweden; and the Department of Pathology and Immunology of the Washington University School of Medicine in St. Louis, Mo.
Additional institutions involved included the Department of Cellular, Molecular and Developmental Biology, the Department of Computer Science and the Department of Chemistry and Biochemistry of the University of Colorado at Boulder; and the Howard Hughes Medical Institute.
The study, "Transient inability to manage Proteobacteria drives gut inflammation in TLR5-deficient mice," appears in the August 16 print edition of the journal Cell Host & Microbe.
For more about the Center for Inflammation, Immunity and Infection at GSU, visit http://inflammation.gsu.edu.
Georgia State University
Related Obesity Articles:
Doctors have a specific definition of what it means to be overweight or obese, but in the social world, gender, race and generation matter a lot for whether people are judged as 'thin enough' or 'too fat.'
Social and economic factors have led to a dramatic rise in type 2 diabetes and obesity around the world.
Three out of four (75 percent) people in the UK are unaware of the link between obesity and cancer, according to a new Cancer Research UK report published today.
Obesity is on the rise in Indonesia, one of the largest studies of the double burden of malnutrition in children has revealed.
A clear and significant increase in obesity continued from 1999 through 2014, according to an analysis of data on United States children and adolescents age 2 to 19 years.
Researchers will be examining how agricultural and food processing practices may affect brown fat activity directly or indirectly.
The growing obesity epidemic, which is predicted to affect more than half of all European citizens by 2030, will be the focus of European Obesity Day to be held on May 21.
Researchers developed a new laboratory method that allowed them to identify GABA as a key player in the complex brain processes that control appetite and metabolism.
Obesity can sometimes be shut down.
This FASEB Conference focuses on the interactions between obesity and immune cells, focusing in particular on how inflammation in various organs influences obesity and obesity-related complications.
Related Obesity Reading:
The Obesity Code: Unlocking the Secrets of Weight Loss
by Dr. Jason Fung (Author), Timothy Noakes (Foreword)
Fung zeroes in on why insulin resistance has become so prevalent and offers specific outside-the-box solutions that have emerged as the key to maximizing health."
—Jimmy Moore, author, Keto Clarity and Cholesterol Clarity
Everything you believe about how to lose weight is wrong. Weight gain and obesity are driven by hormones—in everyone—and only by understanding the effects of insulin and insulin resistance can we achieve lasting weight loss.
In this highly readable and provocative book, Dr. Jason Fung sets out an original, robust theory of obesity... View Details
Obesity: Evaluation and Treatment Essentials, Second Edition
by G. Michael Steelman (Editor), Eric C. Westman (Editor)
Obesity is considered a complex and multifactorial disease. Its treatment, therefore, must also be multimodal and tailored to meet the needs of each patient. Obesity: Evaluation and Treatment Essentials presents a wide spectrum of practical treatment protocols for obesity including exercise, pharmacology, behavior modification, and dietary factors, from the point of view of the practicing physician.
The book includes information about the new pharmacotherapy available for the treatment of obesity. It also includes a chapter on medical treatment of pediatric obesity that... View Details
The Obesity Epidemic: What caused it? How can we stop it?
by Zoe harcombe (Author)
"The Obesity Epidemic: What caused it? How can we stop it?" does what it says in the title - it answers those two critical questions. It takes you on the journey that the author, Zoe Harcombe went on to answer those questions and hopefully it will shock you as much as it shocked her. The starting point must be - when did The Obesity Epidemic start? The graphs and tables show a stunning increase in obesity levels at the turn of the 1980's and obesity literally takes off, like an aeroplane trajectory, from that point onwards. Obesity in the UK, as an example, increases almost 10 fold between... View Details
Practical Manual of Clinical Obesity
by Robert Kushner (Author), Victor Lawrence (Author), Sudhesh Kumar (Author)
This accessible guide to obesity and its clinical management provides clear, didactic, clinically focused guidance for all healthcare professionals involved in the treatment and management of patients with obesity, thus acting as a repository of essential practical knowledge. It is an ideal practical guide for registrars and residents in endocrinology and metabolic disease, as well as all other health professionals who regularly manage obese patients, such as specialist obesity and diabetes nurses, dietitians, and general practitioners with an interest in obesity management. View Details
The Obesity Paradox: When Thinner Means Sicker and Heavier Means Healthier
by Carl J. Lavie M.D. (Author)
Most of us think that longevity hinges on maintaining a normal Body Mass Index. But research conducted over the last decade hit the media in January with explosive news: Overweight and even moderately obese people with certain chronic diseases—from heart disease to cancer— often live longer and fare better than normalweight individuals with the same ailments.
In this groundbreaking book, Carl Lavie, MD, reveals the science behind the obesity paradox and shows us how to achieve maximum health rather than minimum weight. Lavie not only explains how extra fat provides additional fuel... View Details
The Obesity Epidemic: Why Diets and Exercise Don't Work―and What Does
by Robyn Toomath (Author)
In a world where charlatans promise to fix the alarming obesity epidemic with a silver-bullet diet or trendy new exercise program, Robyn Toomath, a physician and realist, steps out of the fray to deliver some tough news: it’s really hard to lose weight. Dispelling common myths and telling provocative truths about weight gain―and loss―The Obesity Epidemic is an engaging investigation into the complicated factors that lead to obesity.
While genes certainly play a part, Toomath argues, more people are fat than ever before because most of us consume significantly more... View Details
Summary of Jason Fung's The Obesity Code: Key Takeaways & Analysis
by Sumoreads (Author)
PLEASE NOTE: This is a summary, analysis and review of the book and not the original book.
Extensive research makes "The Obesity Code" a time machine to back when Western countries became fat nations, an extensive exploration of the hormonal human body, an exposé of the pervasive myths that keep people fat, and a clear path to systematic weight loss.
This SUMOREADS Summary & Analysis offers supplementary material to "The Obesity Code: Unlocking the Secrets of Weight Loss" to help you distill the key takeaways, review the book's content, and further... View Details
Obesity Cancer & Depression: Their Common Cause & Natural Cure
by F. Batmanghelidj (Author)
This book, the result of over 20 years of research, looks at the conditions of obesity, cancer and depression through a new physiological perspective and offers a new approach in preventing and treating these conditions View Details
The Obesity Myth: Why America's Obsession with Weight is Hazardous to Your Health
by Paul Campos (Author)
A provocative exposé of America's self-defeating war on obesity challenges conventional wisdom regarding the cultural, medical, and political meaning of weight, arguing against the myth that falsely equates thinness with health and explaining why dieting is bad for the health, how the media misinform the public, and the link between racial and body-based prejudice. 35,000 first printing. View Details
Obesity: The Medical Practitioner's Essential Guide
by Robin P. Blackstone (Author)
This book is the most current, comprehensive medical text focusing specifically on obesity and its related syndromes and diseases. This text takes the newest science and latest research about obesity and renders the information imminently readable and immediately useful to the medical practitioner charged with providing best practices health care for patients who are obese. In the process, this text scientifically clarifies obesity as a disease of epidemic proportions, debunks common myths about obesity, and challenges medicine’s traditional and oftentimes limited view of obesity. More... View Details