Heritability of thoracic spine curvature

August 02, 2016

BOSTON - August 2, 2016 - Researchers from the Harvard affiliated Hebrew SeniorLife Institute for Aging Research (IFAR) recently published a study in the Journal of Bone and Mineral Research, suggesting that hyperkyphosis may be heritable, or passed on from parents to offspring.

"Hyperkyphosis is a serious condition characterized by extreme forward curvature of the upper spine. It affects as many as 20 to 40 percent of older individuals. However, the causes are poorly understood," said Lisa Samelson, senior investigator for the study, and associate scientist at IFAR and assistant professor at Harvard Medical School.

Samelson's team used computed tomography (CT) images to evaluate thoracic spine curvature, muscle size, and other spine traits in more than 2,000 older adults. Data for the research was collected in two generations of families enrolled in the Framingham Heart Study.

Michelle Yau, a post-doctoral research fellow at IFAR and lead author of the study, added, "Our study is important because it advances our understanding of hyperkyphosis in two ways. First, we found evidence of a strong influence of heredity on hyperkyphosis. Heritability was 54% which suggests that more than half the variation in thoracic spine curvature may be under genetic control. Second, we found that the genetic determinants of hyperkyphosis may also be responsible for bone and muscle loss of the spine that occurs with aging."

Hyperkyphosis can cause disfigurement as well as difficulties with breathing, walking, and carrying out activities of daily life. By quantifying the contribution of genetic factors to development of excessive forward curvature in older adults, this study provides important new insight into the etiology of hyperkyphosis that may help inform prevention efforts in the future.
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Funding was supported by the National Institute on Aging (NIA) under grant number R01AG041658 and T32AG023480, the National Heart, Lung and Blood Institute's Framingham Heart Study (Contract No. HHSN268201500001I), and the Friends of Hebrew SeniorLife.

About Institute for Aging Research

Scientists at the Institute for Aging Research seek to transform the human experience of aging by conducting research that will ensure a life of health, dignity and productivity into advanced age. The Institute carries out rigorous studies that discover the mechanisms of age-related disease and disability; lead to the prevention, treatment and cure of disease; advance the standard of care for older people; and inform public decision-making. The Musculoskeletal Center within IFAR studies conditions affecting bone, muscle, and joint health with aging.

About Hebrew SeniorLife

Hebrew SeniorLife, an affiliate of Harvard Medical School, is a national senior services leader uniquely dedicated to rethinking, researching and redefining the possibilities of aging. Based in Boston, the non-profit, non-sectarian organization has provided communities and health care for seniors, research into aging, and education for geriatric care providers since 1903. For more information about Hebrew SeniorLife, visit http://www.hebrewseniorlife.org, follow us on Twitter @H_SeniorLife, like us on Facebook or read our blog.

Hebrew SeniorLife Institute for Aging Research

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