Nav: Home

Twin study highlights importance of both genetics and environment on gene activity

August 03, 2018

New research highlights the extent to which epigenetic variation is influenced by both inherited and environmental factors.

Epigenetic processes affect the expression or activity of genes without changing the underlying DNA sequence and are believed to be one mechanism by which the environment can interact with the genome.

Now, an international group of researchers including teams from the University of Exeter, King's College London, and Duke University in the USA have published a study in PLOS Genetics, using a unique cohort of over 700 pairs of twins to identify the factors influencing chemical modifications to DNA across the genome. In the study, funded by the Medical Research Council, the team compared the similarities between identical and non-identical twins, and found that epigenetic marks are more similar between identical twins - highlighting the role of DNA sequence variation in regulating gene activity. They also found that sites at which epigenetic variation is strongly linked to environmental exposures - such as smoking and obesity - are also partly under genetic control.

Professor Jonathan Mill, of the University of Exeter Medical School, led the study. He said: "These results highlight how both heritable and environmental factors can influence the way in which genes are expressed and function, with important implications for studies of health and disease."

Dr Eilis Hannon, of the University of Exeter Medical School, was first author on the paper. She commented "Our study provides a useful framework for interpreting the results of epigenetic epidemiological studies and shows that epigenetic differences are a potential mechanism linking genetic variation to gene regulation."
-end-
The paper, "Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins", is published in PLOS Genetics. Authors are Eilis Hannon, Olivia Knox, Karen Sugden, Joe Burrage, Chloe C Y Wong, Daniel W Belsky, David L Corcoran, Louise Arseneault, Terrie E Moffitt, Avshalom Caspi, and Jonathan Mill. Additional support was provided by the National Institute of Child Health and Human Development, a Distinguished Investigator Award from the American Asthma Foundation to Professor Mill, and by the Jacobs Foundation. Some of the work reported in the study used a high-performance computing facility partially supported by a grant from the North Carolina Biotechnology Center.

University of Exeter

Related Dna Articles:

Penn State DNA ladders: Inexpensive molecular rulers for DNA research
New license-free tools will allow researchers to estimate the size of DNA fragments for a fraction of the cost of currently available methods.
It is easier for a DNA knot...
How can long DNA filaments, which have convoluted and highly knotted structure, manage to pass through the tiny pores of biological systems?
How do metals interact with DNA?
Since a couple of decades, metal-containing drugs have been successfully used to fight against certain types of cancer.
Electrons use DNA like a wire for signaling DNA replication
A Caltech-led study has shown that the electrical wire-like behavior of DNA is involved in the molecule's replication.
Switched-on DNA
DNA, the stuff of life, may very well also pack quite the jolt for engineers trying to advance the development of tiny, low-cost electronic devices.
Researchers are first to see DNA 'blink'
Northwestern University biomedical engineers have developed imaging technology that is the first to see DNA 'blink,' or fluoresce.
Finding our way around DNA
A Salk team developed a tool that maps functional areas of the genome to better understand disease.
A 'strand' of DNA as never before
In a carefully designed polymer, researchers at the Institute of Physical Chemistry of the Polish Academy of Sciences have imprinted a sequence of a single strand of DNA.
Doubling down on DNA
The African clawed frog X. laevis genome contains two full sets of chromosomes from two extinct ancestors.
'Poring over' DNA
Church's team at Harvard's Wyss Institute for Biologically Inspired Engineering and the Harvard Medical School developed a new electronic DNA sequencing platform based on biologically engineered nanopores that could help overcome present limitations.

Related Dna Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Digital Manipulation
Technology has reshaped our lives in amazing ways. But at what cost? This hour, TED speakers reveal how what we see, read, believe — even how we vote — can be manipulated by the technology we use. Guests include journalist Carole Cadwalladr, consumer advocate Finn Myrstad, writer and marketing professor Scott Galloway, behavioral designer Nir Eyal, and computer graphics researcher Doug Roble.
Now Playing: Science for the People

#529 Do You Really Want to Find Out Who's Your Daddy?
At least some of you by now have probably spit into a tube and mailed it off to find out who your closest relatives are, where you might be from, and what terrible diseases might await you. But what exactly did you find out? And what did you give away? In this live panel at Awesome Con we bring in science writer Tina Saey to talk about all her DNA testing, and bioethicist Debra Mathews, to determine whether Tina should have done it at all. Related links: What FamilyTreeDNA sharing genetic data with police means for you Crime solvers embraced...