Nav: Home

UH Case Medical Center treats first patient in world on international hypertension study

August 04, 2016

CLEVELAND - University Hospitals Case Medical Center is the first site in the world to use a promising new technology for patients with high blood pressure. Led by Sahil Parikh, MD, the team performed the first procedure on a patient in RADIANCE-HTN, an international clinical trial evaluating the effect of the ReCor Paradise® Renal Denervation System on lowering blood pressure in patients with hypertension.

The new minimally invasive therapy was developed by ReCor Medical, Inc. to treat overactive nerves leading to the kidney, a process called renal denervation. RADIANCE-HTN uses high-intensity ultrasound energy (heat waves) aimed at decreasing the over-activity of these nerves, thereby lowering blood pressure.

"There is strong scientific rationale for this study to evaluate renal denervation as a treatment for hypertension," says Dr. Parikh, interventional cardiologist at UH Harrington Heart & Vascular Institute. "This may be a transformative trial if this treatment is found to help patients who have not been able to control their blood pressure and are therefore at extremely high risk for heart attack, stroke and kidney failure."

The new catheter-based technology uniquely delivers the ultrasound energy circumferentially to target the nerves. Disruption of the renal nerves has been shown in previous studies to prevent, delay or reduce the magnitude of hypertension.

RADIANCE-HTN is a blinded, randomized, sham-controlled trial designed to evaluate the blood pressure lowering effect of the Paradise System in two patient populations: patients currently uncontrolled on three or more blood pressure medications (termed "resistant hypertension") and in participants taking two or fewer blood pressure medications to manage their blood pressure. In the study, half the participants will receive the ultrasound therapy and half the patients will not receive ultrasound treatment; Patients will not know which treatment they receive.

The study is enrolling people between the ages of 18-75 with hypertension that may or may not be controlled with medication. UH is among 40 investigational sites in the US, UK, France, Germany and The Netherlands.

Hypertension is a major public health issue and one of the leading contributors to death from cardiovascular causes in the world. The World Health Organization (WHO) projects more than 1 billion people worldwide have high blood pressure. Despite lifestyle modification and use of multiple antihypertensive medications, roughly 50% of patients do not meet blood pressure goals. Uncontrolled hypertension is associated with severe consequences, including heart attack, stroke, and heart failure, among others.

"Many patients struggle to control their blood pressure on medication," says Dr. Parikh, who is also Assistant Professor of Medicine at Case Western Reserve University School of Medicine and director of the UH Harrington Heart and Vascular Institute Center for Research and Innovation. "We are pleased to participate in this important study evaluating if this new technology can become a treatment option for the millions of patients with hypertension."
About University Hospitals

Founded in May 1866, University Hospitals serves the needs of patients through an integrated network of 18 hospitals, more than 40 outpatient health centers and primary care physician offices in 15 counties throughout Northeast Ohio. At the core of our $4 billion health system is University Hospitals Case Medical Center, ranked among America's best hospitals by U.S. News & World Report. The primary affiliate of Case Western Reserve University School of Medicine, UH Case Medical Center is home to some of the most prestigious clinical and research programs in the nation, including cancer, pediatrics, women's health, orthopedics, radiology, neuroscience, cardiology and cardiovascular surgery, digestive health, transplantation and genetics. Its main campus includes UH Rainbow Babies & Children's Hospital, ranked among the top children's hospitals in the nation; UH MacDonald Women's Hospital, Ohio's only hospital for women; and UH Seidman Cancer Center, part of the NCI-designated Case Comprehensive Cancer Center at Case Western Reserve University. UH is the second largest employer in Northeast Ohio with 26,000 employees. For more information, go to

University Hospitals Case Medical Center

Related Blood Pressure Articles:

Do you really have high blood pressure?
A study by researchers at the University of Montreal Hospital Research Centre (CRCHUM) shows that more than half of family doctors in Canada are still using manual devices to measure blood pressure, a dated technology that often leads to misdiagnosis.
Why do we develop high blood pressure?
Abnormally high blood pressure, or hypertension, may be related to changes in brain activity and blood flow early in life.
For some, high blood pressure associated with better survival
Patients with both type 2 diabetes and acute heart failure face a significantly lower risk of death but a higher risk of heart failure-related hospitalizations if they had high systolic blood pressure on discharge from the hospital compared to those with normal blood pressure, according to a study scheduled for presentation at the American College of Cardiology's 66th Annual Scientific Session.
$9.4 million grant helps scientists explore how cell death from high blood pressure fuels even higher pressure
It's been known for decades that a bacterial infection can raise your blood pressure short term, but now scientists are putting together the pieces of how our own dying cells can fuel chronically high, destructive pressure.
Blood pressure diet improves gout blood marker
A diet rich in fruits, vegetables, low-fat dairy and reduced in fats and saturated fats (the DASH diet), designed decades ago to reduce high blood pressure, also appears to significantly lower uric acid, the causative agent of gout.
New tool to improve blood pressure measurement
Oxford University researchers have developed a prediction model that uses three separate blood pressure readings taken in a single consultation and basic patient characteristics to give an adjusted blood pressure reading that is significantly more accurate than existing models for identifying hypertension.
Blood vessels sprout under pressure
It is blood pressure that drives the opening of small capillaries during angiogenesis.
Better blood pressure control -- by mobile phone
An interactive web system with the help of your mobile phone can be an effective tool for better blood pressure control.
Time to reassess blood-pressure goals
High blood pressure or hypertension is a major health problem that affects more than 70 million people in the US, and over one billion worldwide.
With help from pharmacists, better blood pressure costs $22
A pharmacist-physician collaboration in primary-care offices effectively and inexpensively improved patients' high blood pressure.

Related Blood Pressure Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Digital Manipulation
Technology has reshaped our lives in amazing ways. But at what cost? This hour, TED speakers reveal how what we see, read, believe — even how we vote — can be manipulated by the technology we use. Guests include journalist Carole Cadwalladr, consumer advocate Finn Myrstad, writer and marketing professor Scott Galloway, behavioral designer Nir Eyal, and computer graphics researcher Doug Roble.
Now Playing: Science for the People

#529 Do You Really Want to Find Out Who's Your Daddy?
At least some of you by now have probably spit into a tube and mailed it off to find out who your closest relatives are, where you might be from, and what terrible diseases might await you. But what exactly did you find out? And what did you give away? In this live panel at Awesome Con we bring in science writer Tina Saey to talk about all her DNA testing, and bioethicist Debra Mathews, to determine whether Tina should have done it at all. Related links: What FamilyTreeDNA sharing genetic data with police means for you Crime solvers embraced...