New therapeutic approaches for musculoskeletal diseases highlighted in tissue engineering

August 04, 2017

New Rochelle, NY, August 4, 2017--In a forthcoming special issue of Tissue Engineering on "Strategic Directions in Musculoskeletal Tissue Engineering," Guest Editors Megan Killian, PhD, University of Delaware, MD and Anne Gingery, PhD, Mayo Clinic, MI have compiled a diverse group of scientific articles by leading researchers who are using novel approaches to tissue engineering to develop treatments for musculoskeletal disorders. The special collection of articles will be published in Tissue Engineering, Part A and Part B, peer-reviewed journals from Mary Ann Liebert, Inc., publishers. Several articles are currently available free on the Tissue Engineering website until September 5, 2017.

The issue includes an article by Robby Bowles, PhD, University of Utah, Salt Lake City and coauthors from University of Utah, Duke University, Durham, NC and Washington University in St. Louis and Shriners Hospitals for Children-St. Louis, MO, using CRISPR/Cas-9-based technology for epigenomic editing to product cells from the chronic inflammation caused by musculoskeletal diseases. The researchers demonstrated the ability to reduce the expression of genes that code for inflammatory cytokine receptors in adipose-derived stem cells grown in culture. They report their findings in the article entitled "CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments."

In the study "In Vitro Generated Intervertebral Discs: Towards Engineering Tissue Integration,"

J. Paul Santerre, PhD and Rita Kandel, MD, University of Toronto, and coauthors from University of Toronto, Toronto Western Hospital, University of Guelph, and University of Waterloo, Canada, described a two-step process for engineering a biological intervertebral disc implant and demonstrated mechanically stable integration in a cow model. Working toward creating a replacement for degenerated intervertebral discs, a major cause of chronic neck and low back pain, the researchers are pursuing an approach in which they use tissue engineering to create the individual components of the disc and then combine them together in a co-culture system.

A team of researchers led by Stephanie Bryant, University of Colorado, Boulder, examined the degradation behavior of enzyme-sensitive hydrogels, which have shown promise as cell delivery vehicles for cartilage tissue engineering. In the article "Understanding the Spatiotemporal Degradation Behavior of Aggrecanase-Sensitive Poly(ethylene glycol) Hydrogels for use in Cartilage Tissue Engineering" the researchers combined experimental studies and computational approaches to evaluate and model changes in hydrogel density and growth of extracellular matrix over time and how these affected the clustering and other properties of bovine chondrocytes.

"Co-Guest Editors Anne Gingery and Megan Killian Co-Chaired the 2016 Gordon Research Seminar on Musculoskeletal Biology and Bioengineering and have furthered their commitment to the field by leading the assemblage of this excellent set of manuscripts," says Tissue Engineering Co-Editor-in-Chief Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC.

Research reported in this publication was supported by the National Institutes of Health under Award Numbers R03AR068777, R01AR047442, R01AR069588, 5P30CA042014-24, and 1R01AR065441. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
About the Journal

Tissue Engineering is an authoritative peer-reviewed journal published monthly online and in print in three parts: Part A, the flagship journal published 24 times per year; Part B: Reviews, published bimonthly, and Part C: Methods, published 12 times per year. Led by Co-Editors-In-Chief Antonios G. Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Leadership of Tissue Engineering Parts B (Reviews) and Part C (Methods) is provided by John P. Fisher, PhD, University of Maryland and John A. Jansen, DDS, PhD, Radboud University, respectively. Tissue Engineering is the official journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). Complete tables of content and a sample issue may be viewed on the Tissue Engineeringwebsite.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Human Gene Therapy, and Advances in Wound Care. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News) was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

Mary Ann Liebert, Inc./Genetic Engineering News

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