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Detecting Viagra's active ingredient, other dietary supplements' hidden ingredients

August 05, 2015

To lose weight, boost energy or soothe nerves, many consumers turn to dietary supplements. But some of these products contain undeclared substances. To protect consumers from taking something without their knowledge, scientists have developed a technique to determine what secret ingredients could be lurking in these supplements. They report their approach, which helped them find the active Viagra ingredient and other synthetic designer compounds in various products, in ACS' Journal of Agricultural & Food Chemistry.

Dietary supplements can appear to be a healthful option for treating certain health conditions. Their labels list herbs or other natural ingredients that consumers assume are safe to take. But over the past several years, regulators have detected prohibited substances in some of these products that aren't included on the labels. The drug sibutramine is one of these substances. It was once approved for weight loss but was withdrawn after concerns arose that the medication could increase the risk of heart attacks. To catch supplements spiked with sibutramine and other undeclared substances, Zhiqiang Huang, Bin Guo and colleagues came up with a strategy.

Using an advanced liquid chromatography-mass spectrometry screening procedure, the researchers tested more than 100 syrups, capsules and other types of supplements purchased in markets in China and online. The products' labels claimed benefits from blood pressure reduction to enhanced sexual performance. Their approach successfully detected a wide range of targeted adulterants -- including sibutramine and sildenafil, the active ingredient in Viagra -- and other unexpected drug compounds.
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The authors acknowledge funding from the National Science and Technology Support Program, the National Natural Science Foundation of China, the Innovative Research Team in Higher Educational Institutions of Hunan Province and the Education Department of Hunan Province.

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 158,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

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