How common is endometrial cancer in women with postmenopausal bleeding?

August 06, 2018

BottomLine: Postmenopausal bleeding is a common symptom among most women with endometrial cancer but most women with postmenopausal bleeding won't be diagnosed with endometrial cancer, findings that raise questions about how to best manage postmenopausal bleeding for the early detection of endometrial cancer.

Why The Research Is Interesting: Endometrial cancer diagnosed early is often curable with surgery but five-year survival rates plummet for late-stage disease. Accurate estimates of the frequency of postmenopausal bleeding in endometrial cancers and the risk of endometrial cancer in women with postmenopausal bleeding are needed to evaluate whether targeting women with postmenopausal bleeding for early detection is a useful strategy.

Who and When: Nearly 41,000 from 129 studies (34,000 women with postmenopausal bleeding and more than 6,000 women with endometrial cancer)

What (Measures and Outcomes): Pooled frequency of postmenopausal bleeding in women with endometrial cancer and the risk of endometrial cancer in women with postmenopausal bleeding

How (Study Design): This was a systematic review and meta-analysis. A meta-analysis combines the results of multiple studies identified in a systematic review and quantitatively summarizes the overall association between the same exposure and outcomes measured across all studies.

Authors: Megan A. Clarke, Ph.D., M.H.S., of the National Cancer Institute, Rockville, Maryland, and coauthors

Results: The pooled frequency of postmenopausal bleeding among women with endometrial cancer was 91 percent, while the pooled risk of endometrial cancer among women with postmenopausal bleeding was 9 percent.

Study Limitations: Some data were inconsistently reported and other available data were insufficient.

Related Material: The invited commentary, "Opportunities for Early Detection of Endometrial Cancer in Women with Postmenopausal Bleeding," by Kristen A. Matteson, Women and Infants Hospital, Providence, Rhode Island, and coauthors is available on the For The Media website.

To Learn More: The full study is available on the For The Media website.

(doi:10.1001/jamainternmed.2018.2820)

Editor's Note: The article contains funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
-end-
Want to embed a link to this study in your story? Links will be live at the embargo time http://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2018.2820

JAMA Internal Medicine

Related Endometrial Cancer Articles from Brightsurf:

Endometrial scratch of no value to first-time IVF patients in a large randomized trial
An add-on treatment commonly offered to patients in preparation for IVF has proved ineffective in a large-scale randomized trial of more than 1000 women.

Yale Cancer Center study validates combination therapy for aggressive endometrial cancer
Yale Cancer Center (YCC) scientists have found that combining the targeted drug trastuzumab with chemotherapy significantly improves survival rates for women with a rare, aggressive form of endometrial cancer.

Combined therapy may improve clinical responses for endometrial, colorectal and gastric tumors
Combined therapy may improve clinical responses for endometrial, colorectal and gastric tumors.

Study identifies risk factors for endometrial cancer
An analysis of 149 scientific studies has identified 24 genetic variants which predispose women to endometrial cancer.

Study surveys molecular landscape of endometrial cancer
The most comprehensive molecular study of endometrial cancer to date has further defined the contributions of key genes and proteins to the disease.

New, detailed molecular roadmap boosts fight against endometrial cancer
Scientists have taken an unprecedented look at the proteins involved in endometrial cancer, commonly known as uterine cancer.

Utah researchers discover key protein in endometrial cancer growth
New research, published today in the journal Cancer Research, outlines findings scientists hope will advance our understanding of endometrial cancer and lead to more effective treatments.

Mayo Clinic researchers look at post menopause as key factor in endometrial cancer
Endometrial cancer is the most common gynecological malignancy in the US and the fourth most common cancer among women.

Endometrial diseases can be imitated in a lab dish, new study shows
Biomedical researchers at KU Leuven have found a new way to study endometrial diseases such as endometriosis and cancer.

Molecular analysis could improve the early detection and prevention of endometrial cancer
Researchers from IDIBELL and ICO lead the proposal to evaluate genomic analyzes in cervical cytologies to improve the detection of cancer of the uterine cavity.

Read More: Endometrial Cancer News and Endometrial Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.