No strong evidence to support aspirin use for IVF

August 09, 2011

A systematic review published in The Cochrane Library did not find compelling evidence to support the routine use of aspirin in women being treated for IVF. The researchers reported that taking aspirin during an IVF cycle did not seem to increase a woman's chances of becoming pregnant.

The use of aspirin during IVF treatment is controversial. Part of the thinking behind any potential benefit is that aspirin may improve the blood flow to the womb and ovaries. However, there are also concerns that taking aspirin may cause miscarriage or complications in pregnancy.

The latest review is an update of a Cochrane Systematic Review published in 2007. The researchers added evidence from new trials giving a total of 13 that together involved 2,653 women. All women were undergoing IVF and in most cases, aspirin was taken as a 100 mg dose once a day. Although one large study suggested some benefit associated with taking aspirin, the overall conclusion was that there was no evidence that aspirin would improve a woman's chances of conceiving compared to placebo. Large trials showing beneficial effects would now be needed to change these conclusions, according to the researchers.

"Couples undergoing IVF often feel so desperate that they are prepared to try anything that may improve their chances of conceiving," said lead researcher Charalambos Siristatidis of the Assisted Reproduction Unit at the University of Athens in Greece. "But given the current evidence, there is still no basis to recommend that women take aspirin to help them become pregnant."

The researchers had looked primarily for trials that used live births as a measure of effectiveness, but only three reported this information. Instead, most studies reported pregnancies and the number of women who became pregnant in the group given aspirin was about the same as in group given placebos. Five studies reported miscarriage rate and found no difference between those taking aspirin and those taking placebos.

"It was disappointing to see that so few of the studies reported live birth rate as this is ultimately the outcome all couples undergoing IVF are interested in," said Siristatidis. "The lack of information on miscarriage rate is also concerning given previous studies that have linked higher doses of aspirin to miscarriage."


Related Aspirin Articles from Brightsurf:

An aspirin a day keeps the bowel doctor away
A regular dose of aspirin to reduce the risk of inherited bowel cancer lasts at least 10 years after stopping treatment, research has revealed.

What are the risks and benefits of low-dose aspirin?
Low-dose aspirin significantly lowers cardiovascular disease risk but increases the risk of bleeding, according to a review published in the British Journal of Clinical Pharmacology.

Benefit seen for ticagrelor alone, without aspirin, in patients with ACS
The research was presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC).

Study: An aspirin a day does not keep dementia at bay
Taking a low-dose aspirin once a day does not reduce the risk of thinking and memory problems caused by mild cognitive impairment or probable Alzheimer's disease, nor does it slow the rate of cognitive decline, according to a large study published in the March 25, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Aspirin's health benefits under scrutiny
Taking a baby aspirin every day to prevent a heart attack or stroke should no longer be recommended to patients who haven't already experienced one of these events.

Aspirin may no longer be effective as cardiovascular treatment
A new paper in Family Practice, published by Oxford University Press, found that the widespread use of statins and cancer screening technology may have altered the benefits of aspirin use.

Migraine headaches? Consider aspirin for treatment and prevention
Evidence from 13 randomized trials of the treatment of migraine in 4,222 patients and tens of thousands of patients in prevention of recurrent attacks supports the use of high dose aspirin from 900 to 1,300 milligrams to treat acute migraine as well as low dose daily aspirin from 81 to 325 milligrams to prevent recurrent attacks.

Aspirin use after biliary tract cancer diagnosis
Researchers in this observational study examined if aspirin use after a diagnosis of a biliary tract cancer, which includes gallbladder cancer, was associated with reduced risk of death among nearly 3,000 patients.

Aspirin may prevent air pollution harms
A new study is the first to report evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin may lessen the adverse effects of air pollution exposure on lung function.

Aspirin should not be recommended for healthy people over 70
Low-dose aspirin does not prolong disability-free survival of healthy people over 70, even in those at the highest risk of cardiovascular disease.

Read More: Aspirin News and Aspirin Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to