Nav: Home

CU School of Medicine's Kenneth Tyler article in New England Journal of Medicine

August 09, 2018

AURORA, Colo. (Aug. 9, 2018) - Kenneth Tyler, MD, the Louise Baum Endowed Chair in Neurology at the University of Colorado School of Medicine, is author of a review article about acute viral encephalitis in the current issue of The New England Journal of Medicine.

Review articles are a regular feature in the prestigious medical journal and are written by experts in their fields who offer an overview of the current knowledge about a specific health condition. Such articles discuss a condition's epidemiology, clinical profiles, and diagnostic strategies.

Tyler, who holds appointments in the CU School of Medicine's departments of neurology, medicine, and immunology and microbiology, is a leading researcher and clinician contributing to a better understanding of acute viral encephalitis and improved care for patients infected with the virus. The School of Medicine is home to an internationally recognized Neuro-Infectious Diseases Group, a multidisciplinary collaborative of faculty whose goal is to better understand infectious diseases that affect the nervous system. The group is involved in basic science, clinical, and epidemiologic research projects.

"Viral encephalitis is a major cause of illness and death and imposes a heavy economic burden," Tyler writes in the article, which was published today. "Diagnostic strategies and technologies are being developed to allow identification of an expanding list of pathogens and to differentiate viral encephalitis from its mimics....New therapies to prevent infection and inhibit viral replication are needed."

Each year in the United States, about seven patients are hospitalized for encephalitis per 100,000 population and the cause is unknown in about half of these cases. The estimated median hospitalization charge for a patient with viral encephalitis is $89,600 for West Nile virus encephalitis and $58,000 for HSV [herpes simplex virus] encephalitis. Total annual cost nationally is estimated at $350 million to $540 million, not including the cost of care after discharge, costs for family caregivers, and lost earnings.

Earlier this week, the Colorado Department of Public Health and Environment issued a news release announcing that the first two human cases of West Nile virus in the state in 2018 have been reported in Weld and Delta counties. West Nile virus is most commonly spread to humans by mosquito bites. While most people infected with the virus do not have symptoms, a small percentage (less than 1 percent) can develop neuro-invasive disease, such as encephalitis.
-end-
About the University of Colorado School of Medicine

Faculty at the University of Colorado School of Medicine work to advance science and improve care. These faculty members include physicians, educators and scientists at UCHealth's University of Colorado Hospital, Children's Hospital Colorado, Denver Health, National Jewish Health, and the Denver Veterans Affairs Medical Center. The school is located on the Anschutz Medical Campus, one of four campuses in the University of Colorado system. To learn more about the medical school's care, education, research and community engagement, visit its web site.

University of Colorado Anschutz Medical Campus

Related West Nile Virus Articles:

WSU study shows insulin can increase mosquitoes' immunity to West Nile virus
A discovery by a Washington State University-led research team has the potential to inhibit the spread of West Nile virus as well as Zika and dengue viruses.
Critical protein that could unlock West Nile/Zika virus treatments identified
A team of Georgia State scientists has identified a protein that is critical in controlling replication of West Nile and Zika viruses -- and could be important for developing therapies to prevent and treat those viruses.
West Nile virus in the New World: Reflections on 20 years in pursuit of an elusive foe
Though eradication of West Nile virus remains beyond our capability, the body of knowledge built since its arrival in the Americas in 1999 is now powering efforts to minimize its impact and prepare for the invasion of other mosquito-borne diseases.
Light pollution may be increasing West Nile virus spillover from wild birds
House sparrows infected with West Nile virus (WNV) that live in light polluted conditions remain infectious for two days longer than those who do not, increasing the potential for a WNV outbreak by about 41%.
Mount Sinai researchers find significant delays in West Nile virus reporting
Mount Sinai researchers found significant delays in reporting human cases of West Nile virus, hampering real-time forecasting of the potentially deadly mosquito-borne disease, according to a study in the JAMA Network Open in April.
Insecticide resistance genes affect vector competence for West Nile virus
In a context of overuse of insecticides, which leads to the selection of resistant mosquitoes, it is already known that this resistance to insecticides affects interactions between mosquitoes and the pathogens they transmit.
Where will the world's next Zika, West Nile or Dengue virus come from?
Scientists from the University of California, Davis, have identified wildlife species that are the most likely to host flaviviruses such as Zika, West Nile, dengue and yellow fever.
Vanderbilt discovery could neutralize West Nile virus
Researchers at Vanderbilt University Medical Center and colleagues have isolated a human monoclonal antibody that can 'neutralize' the West Nile virus and potentially prevent a leading cause of viral encephalitis (brain inflammation) in the United States.
West Nile virus reemerged and spread to new areas in Greece in 2017, researchers show
West Nile virus (WNV), which is transmitted via mosquito bites, reemerged and spread to new territories of Greece in 2017 following a two-year hiatus in reported human cases, according to findings presented at the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID).
Researchers develop a novel RNA-based therapy to target West Nile virus
A Yale-led research team developed a new RNA therapy, delivered through the nose, to treat mice infected with West Nile Virus.
More West Nile Virus News and West Nile Virus Current Events

Top Science Podcasts

We have hand picked the top science podcasts of 2019.
Now Playing: TED Radio Hour

Accessing Better Health
Essential health care is a right, not a privilege ... or is it? This hour, TED speakers explore how we can give everyone access to a healthier way of life, despite who you are or where you live. Guests include physician Raj Panjabi, former NYC health commissioner Mary Bassett, researcher Michael Hendryx, and neuroscientist Rachel Wurzman.
Now Playing: Science for the People

#543 Give a Nerd a Gift
Yup, you guessed it... it's Science for the People's annual holiday episode that helps you figure out what sciency books and gifts to get that special nerd on your list. Or maybe you're looking to build up your reading list for the holiday break and a geeky Christmas sweater to wear to an upcoming party. Returning are pop-science power-readers John Dupuis and Joanne Manaster to dish on the best science books they read this past year. And Rachelle Saunders and Bethany Brookshire squee in delight over some truly delightful science-themed non-book objects for those whose bookshelves are already full. Since...
Now Playing: Radiolab

An Announcement from Radiolab