Large-scale COVID-19 vaccine production will require knowledge transfer on manufacturing

August 13, 2020

Massive, rapid production of vaccines to fight COVID-19 will require firms to share know-how not just about what to make, but how to make it, write Nicholson Price and colleagues in this Policy Forum. They cite the recent approval granted by the U.S. Department of Justice to six pharmaceutical firms to exchange "technical information" on manufacturing processes related to monoclonal antibody (mAb) candidates as an example - one that might pave the way for standardizing manufacturing of biologics going forward. As the world rushes to identify safe and effective vaccines and therapeutics to counter the COVID-19 epidemic, attention is turning to the next step: manufacturing these products at enormous scale. This might require, in some cases, companies to make products originally developed by other firms, in which case they may need to know that company's manufacturing methods. For myriad reasons, however, patents on products like vaccines often fail to disclose necessary manufacturing information. "[M]aintaining pervasive secrecy for manufacturing COVID-19 vaccines during the pandemic could cause dramatic failure," Price and colleagues argue. They say that relevant information for quick and effective scale-up must be readily available. Especially when the products that will ultimately be made at scale are as-yet unidentified, broader efforts to ensure their eventual scalability should be a focus. The authors acknowledge that transferring knowledge may not be trivial, including in cases where knowledge has not been codified. However, several entities might facilitate this type of knowledge transfer, they say, including existing international organizations and national governments.
-end-


American Association for the Advancement of Science

Related Vaccines Articles from Brightsurf:

Comprehensive safety testing of COVID-19 vaccines based on experience with prior vaccines
'The urgent need for COVID-19 vaccines must be balanced with the imperative of ensuring safety and public confidence in vaccines by following the established clinical safety testing protocols throughout vaccine development, including both pre- and post-deployment,' write David M.

Safety of HPV vaccines in males
A new analysis published in the British Journal of Clinical Pharmacology shows that HPV vaccines are safe and well tolerated in the male population, and the side effects that may occur after immunization are similar in both sexes.

Model could improve design of vaccines, immunotherapies
Researchers have discovered a general property for understanding how immune cell receptors sense and respond to microbial signals, which could lead to more effective vaccines for both existing and novel viruses.

Better vaccines are in our blood
Red blood cells don't just shuttle oxygen from our lungs to our organs: they also help the body fight off infections by capturing pathogens in the blood and presenting them to immune cells in the spleen.

Challenges in evaluating SARS-CoV-2 vaccines
With more than 140 SARS-CoV-2 vaccines in development, the race is on for a successful candidate to help prevent COVID-19.

Designing vaccines from artificial proteins
EPFL scientists have developed a new computational approach to create artificial proteins, which showed promising results in vivo as functional vaccines.

Misinformation on vaccines readily available online
Parents researching childhood vaccinations online are likely to encounter significant levels of negative information, researchers at the University of Otago, Wellington, have found.

Battle with the cancer: New avenues from childhood vaccines
A new research from the University of Helsinki showed for the first time how the pre-immunization acquired through common childhood vaccines can be used to enhance therapeutic cancer treatment.

Personalized cancer vaccines
The only therapeutic cancer vaccine available on the market has so far showed very limited efficacy in clinical trials.

Doubts raised about effectiveness of HPV vaccines
A new analysis of the clinical trials of HPV vaccines to prevent cervical cancer raises doubts about the vaccines' effectiveness.

Read More: Vaccines News and Vaccines Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.