Nav: Home

DASH diet may help prevent gout flares

August 15, 2016

New research indicates that a healthy diet can effectively lower blood levels of uric acid, a known trigger of gout. The findings are published in Arthritis & Rheumatology, a journal of the American College of Rheumatology (ACR).

Elevated uric acid in the blood plays a key role in gout, an extremely painful form of arthritis that results in profound disability and healthcare expenses. Diet has long been identified as an important determinant of blood uric acid levels, but there is virtually no clinical trial evidence to inform food choice by physicians and patients.

Stephen Juraschek, MD, PhD, of the Johns Hopkins University School of Medicine, and his colleagues looked at the potential of the Dietary Approaches To Stop Hypertension (DASH) diet, a diet with well-established benefits for lowering blood pressure, for lowering uric acid. The DASH diet emphasizes fruits, vegetables, and low-fat dairy foods and reduced consumption of saturated fat, total fat, and cholesterol. It also contains whole grains, lean meats, fish, nuts, and beans.

The investigators assessed a randomized, crossover feeding trial in 103 adults with pre- or stage 1 hypertension. Participants were randomly assigned to receive either the DASH diet or a control diet (typical of the average American diet) and were further fed low, medium, and high sodium levels for 30 days, each in random order.

The DASH diet lowered uric acid on average by 0.35 mg/dL. In individuals with uric acid levels >7 mg/dL however, which is common among patients with gout, the DASH diet lowered uric acid by >1 mg/dL. While the researchers hypothesized that reducing sodium intake would lower uric acid levels, they found that the opposite was true: higher sodium intake (which was about equal to the average sodium consumed in a typical American diet) decreased uric acid levels compared with low sodium intake. The mechanism by which increased sodium intake decreases uric acid is unclear.

The findings suggest that the DASH diet may represent an effective, non-pharmacologic approach to prevent flares in patients with gout. "Physicians may now confidently recommend the DASH diet to patients with gout in order to lower uric acid levels," said Dr. Juraschek. "Our findings also show how sodium, or salt, can alter uric acid levels, which provides important insights in further understanding dietary triggers of gout flares."

The research was supported by cooperative agreements and grants from the National Heart, Lung, and Blood Institute and by the General Clinical Research Center Program of the National Center for Research Resources.
-end-
Media interested in a copy of the study should contact sciencenewsroom@wiley.com.

Article: "Effects of the Dietary Approaches To Stop Hypertension (DASH) Diet and Sodium Intake on Serum Uric Acid." Stephen P. Juraschek, Allan C. Gelber, Hyon K Choi, Lawrence J Appel, Edgar R Miller III. Arthritis & Rheumatology; Published Online: August 15, 2016 (DOI: 10.1002/art.39813).

URL Upon Publication: http://doi.wiley.com/10.1002/art.39813

Author Contact: Marin Hedin, Assistant Director for Media Relations at Johns Hopkins University, at mhedin2@jhmi.edu or +1 (410) 502-9429.

About the Journal

Arthritis & Rheumatology is an official journal of the American College of Rheumatology (ACR) and covers all aspects of inflammatory disease. The American College of Rheumatology (http://www.rheumatology.org) is the professional organization whose members share a dedication to healing, preventing disability, and curing the more than 100 types of arthritis and related disabling and sometimes fatal disorders of the joints, muscles, and bones. Members include practicing physicians, research scientists, nurses, physical and occupational therapists, psychologists, and social workers. The journal is published by Wiley on behalf of the ACR. For more information, please visit http://wileyonlinelibrary.com/journal/art.

About Wiley

Wiley is a global provider of knowledge and knowledge-enabled services that improve outcomes in areas of research, professional practice and education. Through the Research segment, the Company provides digital and print scientific, technical, medical, and scholarly journals, reference works, books, database services, and advertising. The Professional Development segment provides digital and print books, online assessment and training services, and test prep and certification. In Education, Wiley provides education solutions including online program management services for higher education institutions and course management tools for instructors and students, as well as print and digital content. The Company's website can be accessed at http://www.wiley.com.

Wiley

Related Hypertension Articles:

ACP and AAFP release new hypertension recommendations
The American College of Physicians (ACP) and the American Academy of Family Physicians (AAFP) have published an evidence-based clinical practice guideline on the appropriate systolic blood pressure (the top number in a reading) target for adults 60 years old and older with hypertension.
Hypertension and prehypertension underdiagnosed and undertreated in US children
Hypertension and prehypertension in children often go undiagnosed, according to a new study published today in Pediatrics.
Hypertension: Releasing the pressure at its source
Researchers at the University of Bristol and Afferent Pharmaceuticals have identified a potential new way of treating high blood pressure, or hypertension, by targeting aberrant nerve signals in the carotid bodies, which sit on the common carotid arteries on each side of the neck.
To beat hypertension, take the 'clinic' to the people
Eliminating racial disparities in the outcomes of programs to control blood pressure can be accomplished with a few one-on-one coaching sessions delivered by health professionals -- but not if the program requires people to get to a clinic, according to results of a new Johns Hopkins Medicine study.
Virgin olive oil and hypertension
Oleic acid plus a constellation of minor constituents as a natural antihypertensive.
Health insights: Fighting hypertension
Two faculty members at The University of Texas at Arlington's College of Nursing and Health Innovation have won a $376,000 National Institutes of Health grant to investigate differences in vascular responses between black and other groups.
Guidelines first to focus on children with pulmonary hypertension
The first guidelines developed for children with pulmonary hypertension are the result of a collaboration between heart and lung experts and their review of 600 studies.
Three-quarters of stroke patients in China have hypertension
Three-quarters of stroke patients in China have hypertension, reveals research presented at the 26th Great Wall International Congress of Cardiology by Dr.
Pulmonary hypertension: A growing problem in US children
A review of 15 years' worth of data in a national pediatric medical database has documented a substantial increase in the rate of hospitalizations for children with a form of high blood pressure once most common in those with congenital heart disease.
Pharmacists help patients with hypertension
Patients with hypertension benefit from interacting with a medical team that includes a pharmacist.

Related Hypertension Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Setbacks
Failure can feel lonely and final. But can we learn from failure, even reframe it, to feel more like a temporary setback? This hour, TED speakers on changing a crushing defeat into a stepping stone. Guests include entrepreneur Leticia Gasca, psychology professor Alison Ledgerwood, astronomer Phil Plait, former professional athlete Charly Haversat, and UPS training manager Jon Bowers.
Now Playing: Science for the People

#524 The Human Network
What does a network of humans look like and how does it work? How does information spread? How do decisions and opinions spread? What gets distorted as it moves through the network and why? This week we dig into the ins and outs of human networks with Matthew Jackson, Professor of Economics at Stanford University and author of the book "The Human Network: How Your Social Position Determines Your Power, Beliefs, and Behaviours".