Tumor suppressor activity of PTEN

August 16, 2005

Using transgenic mice specifically lacking the PTEN gene in endothelial cells, Dr. Akira Suzuki and colleagues demonstrate that PTEN is required for normal cardiovascular development and that its loss enhanced tumor angiogenesis.

To be published in the September 1 issue of G&D, this new data suggests that PTEN regulates vascular growth factor (VGF) signaling to modulate cardiovascular development and post-natal neovascularization. Loss of PTEN in murine endothelial cells results is dysregulated VGF signaling, enhanced angiogenesis, and accelerated tumor growth.

Their results suggest that an individual who inherits a mutated PTEN allele, such as Cowden disease patient, is not only at risk for additional tumorigenic mutations, but may also experience accelerated growth of tumors due to enhanced angiogenesis. Moreover, the PTEN/PI3K pathway in endothelial cells is an attractive therapeutic target for the treatment of various malignancies.
-end-


Cold Spring Harbor Laboratory

Related Endothelial Cells Articles from Brightsurf:

JACC: BTS study looks at COVID-19's impact on cardiovascular tissue, endothelial cells
In the paper, ''Cardiorenal tissues express SARS-CoV-2 entry genes and basigin (BSG/CD147) increases with age in endothelial cells,'' publishing in JACC: Basic to Translational Research, researchers used publicly available gene expression data to determine the relative expression of key SARS-CoV-2 host entry/ processing genes in human cardiorenal tissues, including aorta, coronary artery, heart (atria and left ventricle), whole blood and the kidney and for comparison the colon, spleen and lung.

New way to target some rapidly dividing cancer cells, leaving healthy cells unharmed
Scientists at Johns Hopkins Medicine and the University of Oxford say they have found a new way to kill some multiplying human breast cancer cells by selectively attacking the core of their cell division machinery.

Nutrient deficiency in tumor cells attracts cells that suppress the immune system
A study led by IDIBELL researchers and published this week in the American journal PNAS shows that, by depriving tumor cells of glucose, they release a large number of signaling molecules.

Scientists modify CAR-T cells to target multiple sites on leukemia cells
In a preclinical study, scientists engineer new CAR-T cells to attack three sites on leukemia cells, instead of one.

Sphingotec's endothelial function biomarker bio-ADM® improves risk stratification of sepsis patients at ICUs
New study data show that monitoring blood levels of sphingotec's endothelial function biomarker bio-ADMĀ® on top of guideline parameter lactate improves risk stratification of sepsis patients admitted to intensive care units.

sphingotec's endothelial function biomarker bio-ADM® predicts need for organ support in general ICU patient population
Data from more than 2,000 patients enrolled in the FROG-ICU study demonstrate that high levels of bioactive adrenomedullin (bio-ADMĀ®) predict the need for organ support, ionotropes, and vasopressors in the general patient population at admission to the intensive care unit (ICU).

First-of-its-kind study in endothelial stem cells finds exposure to flavored e-cigarette liquids, e-cigarette use exacerbates cell dysfunction
There has been a rapid rise in e-cigarette use, but its health effects have not been well-studied and their effect on vascular health remains unknown.

Dead cells disrupt how immune cells respond to wounds and patrol for infection
Immune cells prioritise the clearance of dead cells overriding their normal migration to sites of injury.

Transplanted bone marrow endothelial progenitor cells delay ALS disease progression
Transplanting human bone marrow-derived endothelial progenitor cells into mice mimicking symptoms of amyotrophic lateral sclerosis (ALS) helped more motor neurons survive and slowed disease progression by repairing damage to the blood-spinal cord barrier, University of South Florida researchers report.

Revealed: How the 'Iron Man' of immune cells helps T cells fight infection
The immune system's killer T cells are crucial in fighting viral infections.

Read More: Endothelial Cells News and Endothelial Cells Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.