New practice guidelines on non-invasive ventilation in chronic stable Hypercapnic COPD

August 17, 2020

August 17, 2020 -- A subcommittee of the American Thoracic Society Assembly in Sleep and Respiratory Neurobiology has released new clinical practice guidelinesto help advise clinicians on the optimal management of patients with chronic obstructive pulmonary disease (COPD) and chronic hypercapnia. Hypercapnia is the buildup of carbon dioxide in the bloodstream. The guidelines, published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine, is titled "Long-Term Non-Invasive Ventilation in Chronic Stable Hypercapnic Chronic Obstructive Pulmonary Disease: An Official American Thoracic Society Guideline."

The committee, comprised of leading clinicians working in pulmonary and critical care medicine, as well as patient representatives, developed a consensus approach and summarized evidence for addressing five PICO (patients, intervention, comparator, outcome) questions related to non-invasive ventilation (NIV) for chronic hypercapnic COPD. Recommendations were formulated by the panel of pulmonary and sleep physicians, respiratory therapists and methodologists using the Evidence-to-Decision framework, a systematic and transparent approach to groups making well-informed health care recommendations.

While NIV is used for patients with COPD and chronic hypercapnia, up to this point, evidence for clinical efficacy and optimal management of therapy have been limited.

"This guideline is needed because patients with severe COPD are very sick and have few therapies that have been shown to improve outcomes," said guideline Chair Robert L. Owens, MD, associate professor, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego. "Clinicians who care for these patients need information about whether to consider non-invasive ventilation and some practical advice on how to set up patients with NIV."

The group's main recommendations are to: To develop each of the recommendations, the panel reviewed results from numerous randomized clinical trials, and looked at such factors as health equity and availability of pulmonary and critical care specialists in medically underserved areas, as well as the likelihood of patient compliance. Because some or all of these issues may impact each of the recommendations, all recommendations were considered conditional. The group outlined unanswered questions for each recommendation, as well as future research directions. They also examined what other specialty organizations were saying on these issues.

"It is exciting to consider NIV as additional therapy for those with hypercapnic COPD," the authors stated. "However, there are many issues to consider."

Among these issues are: appropriate patient selection; implementation barriers; the need for more data to guide the goals of therapy, especially on how clinicians should target PaCO2; addressing regulatory/payor considerations on the ability to obtain home NIV for COPD, and the potential for worsening health care disparities due to the cost and expertise needed to provide NIV for patients with stable hypercapnic COPD.

Dr. Owens concluded, "This guideline is needed now because studies in the last few years have shown improved outcomes with non-invasive ventilation for patients with severe COPD. The guideline incorporates recent studies, while also highlighting priority areas for research."
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The ATS has published nearly 20 clinical practice guidelines on various conditions, ranging from allergy and asthma to TB and other pulmonary infections. For ATS guideline implementation tools and derivatives, go here.

American Thoracic Society

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