Nav: Home

Lung function declines as chest deformity deepens

August 18, 2011

A common deformity that cases a depression in the chest wall inhibits lung function as the cavity grows deeper, a national study of 327 patients published in the Journal of Pediatrics found.

"These results confirm what we have observed anecdotally, that children with more severe pectus excavatum report more incidents of shortness of breath and a higher degree of exercise intolerance," said one of the study's lead authors, Dr. Robert Kelly, a pediatric surgeon at Children's Hospital of The King's Daughters in Norfolk, Virginia.

Pectus excavatum, a condition sometimes known as sunken chest, occurs when the chest cartilage grows abnormally and the chest wall progressively collapses. A CHKD surgeon, Dr. Donald Nuss, developed a minimally invasive surgery to correct the condition 25 years ago, and the hospital has remained at the forefront of treatment and research on chest wall deformities ever since.

The study on lung function included 327 pre-correction pectus excavatum patients ages 6 to 21 from hospitals around the nation, including CHKD. The study used standardized medical measurements to determine the severity of the pectus excavatum and a spirometer, a device that measures the volume of air expelled from the lungs, to assess lung function.

"The results suggest a correlation between the severity of pectus excavatum and lung function," said Dr. Kelly. "The more severe the deformity, the more lung function was compromised." He noted that the effect was primarily from lung restriction, not airway obstruction.

While the decline is relatively modest, Dr. Kelly believes researchers next need to study lung function in pectus excavatum patients at the larger tidal volumes required during exercise.
-end-
The study included collaborators from more than 10 hospitals including Cincinnati Children's Hospital, Children's Hospital Boston, Children's Mercy Hospital in Kansas City and the Hospital for Sick Children at the University of Toronto.Children's Hospital of The King's Daughters is the only freestanding children's hospital in Virginia and serves the medical and surgical needs of children throughout Eastern Virginia and Northeastern North Carolina.

Children's Hospital of The King's Daughters

Related Depression Articles:

Children with social anxiety, maternal history of depression more likely to develop depression
Although researchers have known for decades that depression runs in families, new research from Binghamton University, State University of New York, suggests that children suffering from social anxiety may be at particular risk for depression in the future.
Depression and use of marijuana among US adults
This study examined the association of depression with cannabis use among US adults and the trends for this association from 2005 to 2016.
Maternal depression increases odds of depression in offspring, study shows
Depression in mothers during and after pregnancy increased the odds of depression in offspring during adolescence and adulthood by 70%.
Targeting depression: Researchers ID symptom-specific targets for treatment of depression
For the first time, physician-scientists at Beth Israel Deaconess Medical Center have identified two clusters of depressive symptoms that responded to two distinct neuroanatomical treatment targets in patients who underwent transcranial magnetic brain stimulation (TMS) for treatment of depression.
A biological mechanism for depression
Researchers report that in depressed individuals there are increased amounts of an unmodified structural protein, called tubulin, in lipid rafts compared with non-depressed individuals.
Depression in adults who are overweight or obese
In an analysis of primary care records of 519,513 UK adults who were overweight or obese between 2000-2016 and followed up until 2019, the incidence of new cases of depression was 92 per 10,000 people per year.
Why stress doesn't always cause depression
Rats susceptible to anhedonia, a core symptom of depression, possess more serotonin neurons after being exposed to chronic stress, but the effect can be reversed through amygdala activation, according to new research in JNeurosci.
Which comes first: Smartphone dependency or depression?
New research suggests a person's reliance on his or her smartphone predicts greater loneliness and depressive symptoms, as opposed to the other way around.
Depression breakthrough
Major depressive disorder -- referred to colloquially as the 'black dog' -- has been identified as a genetic cause for 20 distinct diseases, providing vital information to help detect and manage high rates of physical illnesses in people diagnosed with depression.
CPAP provides relief from depression
Researchers have found that continuous positive airway pressure (CPAP) treatment of obstructive sleep apnea (OSA) can improve depression symptoms in patients suffering from cardiovascular diseases.
More Depression News and Depression Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: The Power Of Spaces
How do spaces shape the human experience? In what ways do our rooms, homes, and buildings give us meaning and purpose? This hour, TED speakers explore the power of the spaces we make and inhabit. Guests include architect Michael Murphy, musician David Byrne, artist Es Devlin, and architect Siamak Hariri.
Now Playing: Science for the People

#576 Science Communication in Creative Places
When you think of science communication, you might think of TED talks or museum talks or video talks, or... people giving lectures. It's a lot of people talking. But there's more to sci comm than that. This week host Bethany Brookshire talks to three people who have looked at science communication in places you might not expect it. We'll speak with Mauna Dasari, a graduate student at Notre Dame, about making mammals into a March Madness match. We'll talk with Sarah Garner, director of the Pathologists Assistant Program at Tulane University School of Medicine, who takes pathology instruction out of...
Now Playing: Radiolab

What If?
There's plenty of speculation about what Donald Trump might do in the wake of the election. Would he dispute the results if he loses? Would he simply refuse to leave office, or even try to use the military to maintain control? Last summer, Rosa Brooks got together a team of experts and political operatives from both sides of the aisle to ask a slightly different question. Rather than arguing about whether he'd do those things, they dug into what exactly would happen if he did. Part war game part choose your own adventure, Rosa's Transition Integrity Project doesn't give us any predictions, and it isn't a referendum on Trump. Instead, it's a deeply illuminating stress test on our laws, our institutions, and on the commitment to democracy written into the constitution. This episode was reported by Bethel Habte, with help from Tracie Hunte, and produced by Bethel Habte. Jeremy Bloom provided original music. Support Radiolab by becoming a member today at Radiolab.org/donate.     You can read The Transition Integrity Project's report here.