Nav: Home

Gallstone disease may increase heart disease risk

August 18, 2016

DALLAS, Aug. 18, 2016 - A history of gallstone disease may increase your risk of coronary heart disease, according to new research in the American Heart Association's journal Arteriosclerosis, Thrombosis and Vascular Biology.

Gallstone disease is one of the most common and costly gastrointestinal disorders in the United States. Gallstone disease and coronary heart disease have similar risk factors, including diabetes, obesity, high cholesterol, high blood pressure and poor diet.

In a meta-analysis of seven studies consisting of a total of 842,553 participants and 51,123 cases of coronary heart disease, researchers analyzed the relationship between history of gallstones and the development of coronary heart disease. They found that a history of gallstone disease was linked with a 23 percent increased risk of developing coronary heart disease.

"Our results suggest that patients with gallstone disease should be monitored closely based on a careful assessment of both gallstone and heart disease risk factors," said Lu Qi, M.D., Ph.D., study senior author and professor of epidemiology at Tulane University in New Orleans, Louisiana. "Preventing gallstone disease may also benefit heart health."

In a separate analysis of 269,142 participants from three different studies, the researchers found coronary heart disease occurred more often with a history of gallstone disease because of the shared risk factors. Moreover, the increased risk was similar between women and men.

Interestingly, in the three studies, participants with a history of gallstone disease who were otherwise healthy -- were not obese, diabetic or had high blood pressure -- had a greater risk of coronary heart disease than participants that had these conditions.

Previous studies have reported an increased risk of cardiovascular disease with history of gallstone disease, but these studies lacked U.S. populations, were conducted over short periods, did not confirm the cases of gallstones or did not account for significant risk factors for gallstone diseases such as lifestyle and diet, researchers said.

The researchers did not identify why gallstone disease and coronary heart disease were linked in this study, but one theory is that gallstones may affect bile acid secretion, which has been related to cardiovascular risk factors. In addition, gut microbiota has been related to cardiovascular disease. "Patients with gallstones also have abnormal abundance and metabolism in their gut microbiota", Qi said.

Understanding the factors that link gallstones and coronary heart disease and clinical trials to assess the effects of the factors on cardiovascular health are essential for applying the research findings to clinical practice, Qi said.
-end-
Co-authors are Yan Zheng, M.D., Ph.D.; Min Xu, M.D., Ph.D.; Yanping Li, M.D., Ph.D.; Adela Hruby, Ph.D., MPH; Eric B. Rimm, Sc.D.; Frank B. Hu, M.D., Ph.D.; Janine Wirth, Ph.D.; Christine M. Albert, M.D., MPH; Kathryn M. Rexrode, M.D., MPH and JoAnn E. Manson, M.D., Dr.PH. Author disclosures are on the manuscript.

The National Heart, Lung and Blood Institute, the National Diabetes and Digestive and Kidney Diseases, the Boston Obesity Nutrition Research Center, and the United States -- Israel Binational Science Foundation supported this study.

Additional Resources:

Researcher photo and heart graphic are located in the right column of this release link http://newsroom.heart.org/news/gallstone-disease-may-increase-heart-disease-risk?preview=257316242baee97bbac5a8b043b878eb

Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association's policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at http://www.heart.org/corporatefunding.

American Heart Association

Related Cardiovascular Disease Articles:

A talk with your GP may prevent cardiovascular disease
Having a general practitioner (GP) who is trained in motivational interviewing may reduce your risk of getting cardiovascular disease.
Dilemma of COVID-19, aging and cardiovascular disease
Whether individuals should continue to take angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the context of coronavirus disease 2019 (COVID-19) is discussed in this article.
Air pollution linked to dementia and cardiovascular disease
People continuously exposed to air pollution are at increased risk of dementia, especially if they also suffer from cardiovascular diseases, according to a study at Karolinska Institutet in Sweden published in the journal JAMA Neurology.
New insights into the effect of aging on cardiovascular disease
Aging adults are more likely to have - and die from - cardiovascular disease than their younger counterparts.
Premature death from cardiovascular disease
National data were used to examine changes from 2000 to 2015 in premature death (ages 25 to 64) from cardiovascular disease in the United States.
Ultrasound: The potential power for cardiovascular disease therapy
In the current issue of Cardiovascular Innovations and Applications volume 4, issue 2, pp.
Despite the ACA, millions of Americans with cardiovascular disease still can't get care
Cardiovascular disease (CVD) is the leading cause of death for Americans, yet millions with CVD or cardiovascular risk factors (CVRF) still can't access the care they need, even years after the implementation of the Affordable Care Act (ACA).
Excess weight and body fat cause cardiovascular disease
In the first Mendelian randomization study to look at this, researchers have found evidence that excess weight and body fat cause a range of heart and blood vessel diseases (rather than just being associated with it).
Enzyme may indicate predisposition to cardiovascular disease
Study suggests that people with low levels of PDIA1 in blood plasma may be at high risk of thrombosis; this group also investigated PDIA1's specific interactions in cancer.
Cardiovascular disease in China
This study analyzed data from the Global Burden of Disease Study to look at the rate of cardiovascular disease (CVD) in China along with death and disability from CVD from 1990 to 2016.
More Cardiovascular Disease News and Cardiovascular Disease Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: Reinvention
Change is hard, but it's also an opportunity to discover and reimagine what you thought you knew. From our economy, to music, to even ourselves–this hour TED speakers explore the power of reinvention. Guests include OK Go lead singer Damian Kulash Jr., former college gymnastics coach Valorie Kondos Field, Stockton Mayor Michael Tubbs, and entrepreneur Nick Hanauer.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Dispatch 6: Strange Times
Covid has disrupted the most basic routines of our days and nights. But in the middle of a conversation about how to fight the virus, we find a place impervious to the stalled plans and frenetic demands of the outside world. It's a very different kind of front line, where urgent work means moving slow, and time is marked out in tiny pre-planned steps. Then, on a walk through the woods, we consider how the tempo of our lives affects our minds and discover how the beats of biology shape our bodies. This episode was produced with help from Molly Webster and Tracie Hunte. Support Radiolab today at Radiolab.org/donate.