Nav: Home

Gallstone disease may increase heart disease risk

August 18, 2016

DALLAS, Aug. 18, 2016 - A history of gallstone disease may increase your risk of coronary heart disease, according to new research in the American Heart Association's journal Arteriosclerosis, Thrombosis and Vascular Biology.

Gallstone disease is one of the most common and costly gastrointestinal disorders in the United States. Gallstone disease and coronary heart disease have similar risk factors, including diabetes, obesity, high cholesterol, high blood pressure and poor diet.

In a meta-analysis of seven studies consisting of a total of 842,553 participants and 51,123 cases of coronary heart disease, researchers analyzed the relationship between history of gallstones and the development of coronary heart disease. They found that a history of gallstone disease was linked with a 23 percent increased risk of developing coronary heart disease.

"Our results suggest that patients with gallstone disease should be monitored closely based on a careful assessment of both gallstone and heart disease risk factors," said Lu Qi, M.D., Ph.D., study senior author and professor of epidemiology at Tulane University in New Orleans, Louisiana. "Preventing gallstone disease may also benefit heart health."

In a separate analysis of 269,142 participants from three different studies, the researchers found coronary heart disease occurred more often with a history of gallstone disease because of the shared risk factors. Moreover, the increased risk was similar between women and men.

Interestingly, in the three studies, participants with a history of gallstone disease who were otherwise healthy -- were not obese, diabetic or had high blood pressure -- had a greater risk of coronary heart disease than participants that had these conditions.

Previous studies have reported an increased risk of cardiovascular disease with history of gallstone disease, but these studies lacked U.S. populations, were conducted over short periods, did not confirm the cases of gallstones or did not account for significant risk factors for gallstone diseases such as lifestyle and diet, researchers said.

The researchers did not identify why gallstone disease and coronary heart disease were linked in this study, but one theory is that gallstones may affect bile acid secretion, which has been related to cardiovascular risk factors. In addition, gut microbiota has been related to cardiovascular disease. "Patients with gallstones also have abnormal abundance and metabolism in their gut microbiota", Qi said.

Understanding the factors that link gallstones and coronary heart disease and clinical trials to assess the effects of the factors on cardiovascular health are essential for applying the research findings to clinical practice, Qi said.
-end-
Co-authors are Yan Zheng, M.D., Ph.D.; Min Xu, M.D., Ph.D.; Yanping Li, M.D., Ph.D.; Adela Hruby, Ph.D., MPH; Eric B. Rimm, Sc.D.; Frank B. Hu, M.D., Ph.D.; Janine Wirth, Ph.D.; Christine M. Albert, M.D., MPH; Kathryn M. Rexrode, M.D., MPH and JoAnn E. Manson, M.D., Dr.PH. Author disclosures are on the manuscript.

The National Heart, Lung and Blood Institute, the National Diabetes and Digestive and Kidney Diseases, the Boston Obesity Nutrition Research Center, and the United States -- Israel Binational Science Foundation supported this study.

Additional Resources:

Researcher photo and heart graphic are located in the right column of this release link http://newsroom.heart.org/news/gallstone-disease-may-increase-heart-disease-risk?preview=257316242baee97bbac5a8b043b878eb

Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association's policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at http://www.heart.org/corporatefunding.

American Heart Association

Related Cardiovascular Disease Articles:

Is educational attainment associated with lifetime risk of cardiovascular disease?
Men and women with the lowest education level had higher lifetime risks of cardiovascular disease than those with the highest education level, according to a new study published by JAMA Internal Medicine.
Food policies could lower US cardiovascular disease rates
New research conducted by the University of Liverpool and partners shows that food policies, such as fruit and vegetable subsidies, taxes on sugar sweetened drinks, and mass media campaigns to change dietary habits, could avert hundreds of thousands of deaths from cardiovascular disease (CVD) in the United States.
Cardiovascular disease causes one-third of deaths worldwide
Cardiovascular diseases (CVD), including heart diseases and stroke, account for one-third of deaths throughout the world, according to a new scientific study that examined every country over the past 25 years.
Kidney disease is a major cause of cardiovascular deaths
In 2013, reduced kidney function was associated with 4 percent of deaths worldwide, or 2.2 million deaths.
Cardiovascular disease costs will exceed $1 trillion by 2035
A new study projects that by 2035, cardiovascular disease, the most costly and prevalent killer, if left unchecked, will place a crushing economic and health burden on the nation's financial and health care systems.
Prescribing drugs for cardiovascular disease prevention in the UK
Drugs such as statins that have the potential to prevent strokes and other types of cardiovascular disease have not been prescribed to a large proportion of people at risk in the UK, according to a research article by Grace Turner of the University of Birmingham, Birmingham, UK and colleagues published in PLOS Medicine.
Fatty liver disease contributes to cardiovascular disease and vice versa
For the first time, researchers have shown that a bi-directional relationship exists between fatty liver disease and cardiovascular disease.
More dietary calcium may lower risk of cardiovascular disease
In older people, higher dietary calcium intake may lower the risk of cardiovascular disease, but not of stroke and fracture, new research from South Korea suggests.
Renal hemodynamics and cardiovascular function in health and disease
The SRC will focus on unpublished work that is state-of-the-art in study of cardiovascular and renal disease and hypertension.
Cardiovascular disease in adult survivors of childhood cancer
For adult survivors of childhood cancer, cardiovascular disease presents at an earlier age, is associated with substantial morbidity, and is often asymptomatic.

Related Cardiovascular Disease Reading:

Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Single Volume
by Douglas P. Zipes MD (Author), Peter Libby MD PhD (Author), Robert O. Bonow MD MS (Author), Douglas L. Mann MD (Author), Gordon F. Tomaselli MD (Author)

Pathophysiology of Heart Disease: A Collaborative Project of Medical Students and Faculty
by Leonard S. Lilly MD (Author)

Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 2-Volume Set
by Douglas P. Zipes MD (Author), Peter Libby MD PhD (Author), Robert O. Bonow MD MS (Author), Douglas L. Mann MD (Author), Gordon F. Tomaselli MD (Author)

Pathophysiology of Heart Disease: A Collaborative Project of Medical Students and Faculty (PATHOPHYSIOLOGY OF HEART DISEASE (LILLY))
by Leonard S. Lilly MD (Author)

Prevent and Reverse Heart Disease: The Revolutionary, Scientifically Proven, Nutrition-Based Cure
by Caldwell B. Esselstyn Jr. (Author)

Manual of Cardiovascular Medicine
by Brian P. Griffin MD FACC (Editor)

Concise Cardiovascular Disease Board Review: Key Concepts for Success
by Thomas J. Sawyer (Author)

Braunwald's Heart Disease Review and Assessment (Companion to Braunwald's Heart Disease)
by Leonard S. Lilly MD (Author)

Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 2-Volume Set
by Douglas L. Mann MD (Author), Douglas P. Zipes MD (Author), Peter Libby MD PhD (Author), Robert O. Bonow MD MS (Author)

Human Heart, Cosmic Heart: A Doctor’s Quest to Understand, Treat, and Prevent Cardiovascular Disease
by Dr. Thomas Cowan MD (Author)

Best Science Podcasts 2018

We have hand picked the best science podcasts for 2018. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Circular
We're told if the economy is growing, and if we keep producing, that's a good thing. But at what cost? This hour, TED speakers explore circular systems that regenerate and re-use what we already have. Guests include economist Kate Raworth, environmental activist Tristram Stuart, landscape architect Kate Orff, entrepreneur David Katz, and graphic designer Jessi Arrington.
Now Playing: Science for the People

#504 The Art of Logic
How can mathematics help us have better arguments? This week we spend the hour with "The Art of Logic in an Illogical World" author, mathematician Eugenia Cheng, as she makes her case that the logic of mathematics can combine with emotional resonance to allow us to have better debates and arguments. Along the way we learn a lot about rigorous logic using arguments you're probably having every day, while also learning a lot about our own underlying beliefs and assumptions.