School flu vaccine program reduces community-wide influenza hospitalizations

August 18, 2020

A city-wide school influenza vaccine intervention was associated with a decrease in influenza-associated hospitalizations for all age groups and a decrease in school absence rates among students in seasons with an effective influenza vaccine, according to a new study published this week in PLOS Medicine by Jade Benjamin-Chung of University of California, Berkeley, and colleagues.

Seasonal influenza contributes substantially to hospitalization and mortality, especially among infants and the elderly. Because school-aged children are responsible for the greatest proportion of community-wide influenza transmission, efforts to increase vaccination among children are thought to have the greatest potential to prevent influenza epidemics. In the new study, researchers looked at a school-located influenza vaccination (SLIV) program implemented in more than 95 preschools and elementary schools in Oakland, California. They compared rates of influenza-associated hospitalization and illness-related school absenteeism in the area with the intervention and another nearby school district with similar characteristics that had not been included in the intervention.

At the start of the program, influenza vaccination rates were already more than 50% among elementary school aged children, higher than the rates seen at the outset of similar interventions. During the first two years of the program, the vaccination efforts had little effectiveness, but during this period, the influenza vaccine recommended for children had low effectiveness. By the third and fourth years of the program, 2016-2017 and 2017-2018, when the vaccine was effective, influenza vaccination coverage was 7 and 11% higher among students in the SLIV site. When accounting for pre-program differences in hospitalizations in each area, in the 2016-2017 school year, this increased vaccination rate was associated with a decrease of 17 influenza hospitalizations per 100,000 people (95% CI decrease of 4-30, p=0.008), among all non-elementary-school-aged people in the community. In the following school year, there were 37 fewer influenza hospitalizations per 100,000 people (95% CI decrease of 19-54, p<0.001), among non-elementary-school-aged people, including 160 fewer influenza hospitalizations per 100,000 people aged 65 and older (95% CI decrease of 53-267, p=0.004). The increased vaccination rates at the SLIV site was also associated with a decrease in illness-related school absences per 100 school days during influenza season.

The authors note that school-year- and school-district-specific differences unrelated to the SLIV intervention could have influenced the findings, and that vaccination coverage estimates were based on caregiver reporting.

Still, "Our findings suggest that in populations with moderately high background levels of influenza vaccination coverage, SLIV programs are associated with further increases in coverage and reduced influenza across communities," the authors say.
Research Article: Peer reviewed; experimental study; people

Funding: This study was supported by a grant from the Flu Lab ( to the University of California, Berkeley (Award number: 20142281; PI: AR). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: I have read the journal's policy and the authors of this manuscript have the following competing interests: The following authors report grant support from the Flu Lab to the University of California, Berkeley for the conduct of this research: JBC, BFA, KM, NP, AN, WJ, AEH, AR, JMC. EP reports grant support from the Shoo the Flu organization to the Alameda County Public Health Department. KH reports paid employment from the Shoo the Flu organization. CK reports paid employment from Kaiser Permanente Northern California, Division of Research. PDK and TL report grant support from the U.S. Centers for Disease Control and Prevention to the California Emerging Infections Program.

Citation: Benjamin-Chung J, Arnold BF, Kennedy CJ, Mishra K, Pokpongkiat N, Nguyen A, et al. (2020) Evaluation of a city-wide school-located influenza vaccination program in Oakland, California, with respect to vaccination coverage, school absences, and laboratory-confirmed influenza: A matched cohort study. PLoS Med 17(8): e1003238.

In your coverage please use this URL to provide access to the freely available paper:


Related Influenza Articles from Brightsurf:

Predicting influenza epidemics
Researchers at Linköping University, Sweden, have developed a unique method to predict influenza epidemics by combining several sources of data.

Common cold combats influenza
As the flu season approaches, a strained public health system may have a surprising ally -- the common cold virus.

Scent-sensing cells have a better way to fight influenza
Smell receptors that line the nose get hit by Influenza B just like other cells, but they are able to clear the infection without dying.

New antivirals for influenza and Zika
Leuven researchers have deployed synthetic amyloids to trigger protein misfolding as a strategy to combat the influenza A and Zika virus.

Assessment of deaths from COVID-19, seasonal influenza
Publicly available data were used to analyze the number of deaths from seasonal influenza deaths compared with deaths from COVID-19.

Obesity promotes virulence of influenza
Obesity promotes the virulence of the influenza virus, according to a study conducted in mice published in mBio, an open-access journal of the American Society for Microbiology.

Influenza: combating bacterial superinfection with the help of the microbiota
Frenc researchers and from Brazilian (Belo Horizonte), Scottish (Glasgow) and Danish (Copenhagen) laboratories have shown for the first time in mice that perturbation of the gut microbiota caused by the influenza virus favours secondary bacterial superinfection.

Chemists unveil the structure of an influenza B protein
MIT chemists have discovered the structure of an influenza B protein called BM2, a finding that could help researchers design drugs that block the protein and help prevent the virus from spreading.

How proteins help influenza A bind and slice its way to cells
Researchers have provided new insight on how two proteins help influenza A virus particles fight their way to human cells.

Eating elderberries can help minimize influenza symptoms
Conducted by Professor Fariba Deghani, Dr. Golnoosh Torabian and Dr.

Read More: Influenza News and Influenza Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to