Obesity, depression team up to increase heart-endangering inflammation

August 19, 2003

Obesity and depression may work together to provoke the chronic low-level inflammation associated with atherosclerosis and increased risk of heart disease, according to a new report in the journal Brain, Behavior and Immunity.

Among a large group of German men ages 45 to 74, obese men had significantly higher concentrations of a protein called CRP compared with non-obese men. CRP serves as a signal of artery inflammation and high levels of the protein may be a good predictor of future heart disease.

And depression seems to add to obese men's heart woes: CRP levels were higher in the most depressed obese men than in the less depressed obese men, according to Karl-Heinz Ladwig, Ph.D., of the GSF National Research Center for Environment and Health and colleagues.

Depression did not affect CRP levels among non-obese men, however, suggesting that a combination of obesity and depression may be more risky for some men.

"We cannot provide a convincing explanation why the association between CRP and depression was much stronger in obese than in non-obese participants. However, it may be that both conditions -- obesity and depression -- share a common ground which, in consequence, makes depressed, obese subjects in particular susceptible for coronary heart disease," Ladwig says.

The association between obesity and depression remained strong even after accounting for other factors that can affect CRP levels, including smoking, alcohol consumption and physical activity, according to the researchers.

Twenty-three percent of the 3,205 men included in the study were identified as obese. On the whole, the group of obese men was not any more depressed than the non-obese group, Ladwig says.
-end-
FOR MORE INFORMATION
Health Behavior News Service: 202-387-2829 or www.hbns.org.
Interviews: Contact Karl-Heintz Ladwig at ladwig@gsf.de.
Brain, Behavior and Immunity: Visit www.academicpress.com/bbi.


BY BECKY HAM, STAFF WRITER
HEALTH BEHAVIOR NEWS SERVICE

Center for Advancing Health

Related Depression Articles from Brightsurf:

Children with social anxiety, maternal history of depression more likely to develop depression
Although researchers have known for decades that depression runs in families, new research from Binghamton University, State University of New York, suggests that children suffering from social anxiety may be at particular risk for depression in the future.

Depression and use of marijuana among US adults
This study examined the association of depression with cannabis use among US adults and the trends for this association from 2005 to 2016.

Maternal depression increases odds of depression in offspring, study shows
Depression in mothers during and after pregnancy increased the odds of depression in offspring during adolescence and adulthood by 70%.

Targeting depression: Researchers ID symptom-specific targets for treatment of depression
For the first time, physician-scientists at Beth Israel Deaconess Medical Center have identified two clusters of depressive symptoms that responded to two distinct neuroanatomical treatment targets in patients who underwent transcranial magnetic brain stimulation (TMS) for treatment of depression.

A biological mechanism for depression
Researchers report that in depressed individuals there are increased amounts of an unmodified structural protein, called tubulin, in lipid rafts compared with non-depressed individuals.

Depression in adults who are overweight or obese
In an analysis of primary care records of 519,513 UK adults who were overweight or obese between 2000-2016 and followed up until 2019, the incidence of new cases of depression was 92 per 10,000 people per year.

Why stress doesn't always cause depression
Rats susceptible to anhedonia, a core symptom of depression, possess more serotonin neurons after being exposed to chronic stress, but the effect can be reversed through amygdala activation, according to new research in JNeurosci.

Which comes first: Smartphone dependency or depression?
New research suggests a person's reliance on his or her smartphone predicts greater loneliness and depressive symptoms, as opposed to the other way around.

Depression breakthrough
Major depressive disorder -- referred to colloquially as the 'black dog' -- has been identified as a genetic cause for 20 distinct diseases, providing vital information to help detect and manage high rates of physical illnesses in people diagnosed with depression.

CPAP provides relief from depression
Researchers have found that continuous positive airway pressure (CPAP) treatment of obstructive sleep apnea (OSA) can improve depression symptoms in patients suffering from cardiovascular diseases.

Read More: Depression News and Depression Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.