Annals of Internal Medicine tip sheet for Aug. 21, 2007, issue

August 20, 2007

A systematic review finds that implantable cardioverter defibrillators (ICDs) are safe and significantly reduce death for adults with left ventricular systolic dysfunction (Review, p. 251). In this review of eight randomized controlled trials that reported on mortality and 76 observational studies that examined safety or effectiveness, ICDs reduced death from all causes in patients with left ventricular systolic dysfunction by 20 percent. This reduction came mostly from a 54 percent relative reduction in sudden cardiac deaths, which are usually caused by dangerous heart rhythms.

ICDs are small machines placed under the skin below the collarbone. They monitor the heart's rhythm and give the heart an electrical shock if a dangerous rhythm occurs. Left ventricular systolic dysfunction -- heart muscle weakened from coronary artery disease or heart attack -- carries a high risk for sudden cardiac death.
-end-
Note: Annals of Internal Medicine is published by the American College of Physicians. These highlights are not intended to substitute for articles as sources of information.

American College of Physicians

Related Sudden Cardiac Death Articles from Brightsurf:

Sudden cardiac death often a woman's first sign of heart disease
New research from the Center for Cardiac Arrest Prevention at the Smidt Heart Institute at Cedars-Sinai shows that rates of sudden cardiac arrest are rising following decades of a downward trend.

New research could reduce the risk of sudden cardiac death
New research has shown that by changing the time course of voltage change early in action potential it is possible to both withhold a potentially lethal electrical disturbance and improve the strength of cardiac contraction in heart failure at the same time.

Rare genetic variants predispose to sudden cardiac death
By identifying rare DNA variants that substantially increase risk of sudden cardiac death, researchers have laid the foundation for efforts to identify individuals who could benefit from prevention strategies prior to experiencing symptoms.

Racial disparities in sudden cardiac death rates cannot be explained by known risk factors
A Penn Medicine study, published online today in the Journal of the American College of Cardiology, showed that even after controlling for risk factors like income, education, smoking, exercise, and bad cholesterol, among others, black patients remained at significantly higher risk for sudden cardiac death than white patients.

Preventing sudden cardiac death with genome editing
Gene editing successfully prevented sudden cardiac death in a mouse model of inherited cardiac arrhythmia disorder.

Wearable defibrillator lowers sudden cardiac death, but only when you wear it
An international clinical trial that studied wearable cardioverter defibrillators (WCDs) found that the devices did not significantly reduce sudden cardiac death -- the primary goal of the device -- among patients assigned to the device in the first 90 days after a heart attack, but did lower mortality among those who wore it as prescribed, according to a study led by researchers at UC San Francisco.

New model estimates odds of events that trigger sudden cardiac death
A new computational model of heart tissue allows researchers to estimate the probability of rare heartbeat irregularities that can cause sudden cardiac death.

Mitochondrial DNA could predict risk for sudden cardiac death, heart disease
Johns Hopkins researchers report that the level, or 'copy number,' of mitochondrial DNA -- genetic information stored not in a cell's nucleus but in the body's energy-creating mitochondria -- is a novel and distinct biomarker that is able to predict the risk of heart attacks and sudden cardiac deaths a decade or more before they happen.

New report outlines 10 measures for the prevention of sudden cardiac death
A new report presents 10 quality and performance measures that are intended to help stakeholders--including health systems, legislative bodies, and nongovernmental organizations, as well as healthcare practitioners, patients, families and communities -- in the effort to prevent sudden cardiac death.

Sudden cardiac death of teen reminds physicians of precision medicine
The sudden death of a 13-year-old boy resulted in more than 20 relatives to be incorrectly diagnosed as having a potentially lethal heart rhythm condition.

Read More: Sudden Cardiac Death News and Sudden Cardiac Death Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.