Lipid-Oligonucleotides (LONs) --- Promising materials for bioapplications

August 20, 2020

Lipids are very essential components in composing living systems and are important for cell signaling and nutrient transport. Meanwhile, lipids have been widely used as carriers in many anticancer drugs development because of their capability in increasing solubilization and improving pharmacokinetics of drugs. Based on this, lipid-oligonucleotides (LONs), the new molecular materials have been designed and have shown outstanding properties in different molecular designs for applications from bioanalysis and biosensing to biomedical technologies.

Due to the information-transfer and self-assembly abilities of the two segments, LONs have presented advantages in designing membrane-anchored biosensors and synthetic membrane channels. For example, LONs have been used in the researches of cell membrane anchored sensors for monitoring extracellular molecules and measuring biophysical events on the live cell surface, because of the similarity between the lipid part of LONs and lipid bilayers in cell membrane. Moreover, LONs have great potential in making contributions to developing new therapies and controllable nanoreactors by designing different structures with tunable compositions of two moieties.

Recently, Professor Weihong Tan lead a group of researchers, including Dr. Xiaowei Li, et al. from University of Florida and Dr. Kejun Feng from Huizhou University reported a systematic review discussing this powerful molecular engineering material, LON, and its wide applications from biosensors to biomedicine.

They first summarized the current general synthesis strategies of preparing LONs (pre- and post-synthetic approaches), describing their basic structures and some related characterization analysis of properties, suggesting that LONs have unique recognition ability and excellent stability, which are the prerequisites for biomedical and analytical applications. The special amphiphilic structures of LONs also provide themselves enhancing drug encapsulation and targeted recognition abilities, benefiting the downstream applications.

Then, the researchers discussed the recent advances in applying LONs in various areas. LONs could be modified to build cell membrane anchored biosensors, targeted cancer therapeutics or imaging probes, as well as programmable nanoreactors, indicating that LONs are super versatile materials and could favor different purposes. At the same time, the current challenges and future directions of improving LONs were also mentioned in the review, which may help guide the better developments of LONs-based materials for more biological applications.
-end-
See the article: Lipid-oligonucleotide conjugates for bioapplications
Natl Sci Rev, 2020, https://doi.org/10.1093/nsr/nwaa161

Science China Press

Related Cell Membrane Articles from Brightsurf:

Lighting the way to selective membrane imaging
A team of scientists at Kanazawa University have shown how water-soluble tetraphenylethene molecules can become fluorescent when aggregating at a biomembrane-mimetic liquid-liquid interface.

What membrane can do in dealing with radiation
USTC recently found that polymethylmethacrylate (PMMA) and polyvinyl chloride (PVC) can release acidic substance under γ radiation, whose amount is proportional to the radiation intensity.

Bioelectronic device achieves unprecedented control of cell membrane voltage
Every living cell maintains a voltage across the cell membrane that results from differences in the concentrations of charged ions inside and outside the cell.

Novel cell membrane model could be key to uncovering new protein properties
Researchers have recently shed light on how cell membrane proteins could be influenced by the lipids around them.

Using light's properties to indirectly see inside a cell membrane
Using properties of light from fluorescent probes is at the heart of a new imaging technique developed at Washington University's McKelvey School of Engineering that allows for an unprecedented look inside cell membranes.

Cell 'membrane on a chip' could speed up screening of drug candidates for COVID-19
Researchers have developed a human cell 'membrane on a chip' that allows continuous monitoring of how drugs and infectious agents interact with our cells, and may soon be used to test potential drug candidates for COVID-19.

Scientists synthesize novel artificial molecules that mimic a cell membrane protein
Scientists at Tokyo Institute of Technology (Tokyo Tech) recently developed an artificial transmembrane ligand-gated channel that can mimic the biological structure and function of its natural counterpart.

Across the cell membrane
Aquaporins and glucose transporters facilitate the movement of substances across biological membranes and are present in all kingdoms of life.

Location, location, location: The cell membrane facilitates RAS protein interactions
Many cancer medications fail to effectively target the most commonly mutated cancer genes in humans, called RAS.

New self-forming membrane to protect our environment
A new class of self-forming membrane has been developed by researchers from Newcastle University, UK.

Read More: Cell Membrane News and Cell Membrane Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.