Symposium explores health effects of acrylamide, ways to reduce it in food

August 21, 2007

BOSTON, Aug. 21, 2007 -- Acrylamide, a synthetic chemical widely used as a water treatment agent and in the manufacture of adhesives, dyes and fabrics, has recently been shown to occur naturally in an increasing number of foods ranging from French fries to coffee. Some studies have linked high levels of acrylamide to cancer in animals and neurological damage in humans. Despite uncertainties over acrylamide's actual health effects at the levels found in food, there is heightened public awareness about this compound. The potential health effects of acrylamide and ways to reduce its content in foods will be explored Aug. 21-23 in a special three-day symposium, "Chemistry and Toxicology of Acrylamide," during the 234th national meeting of the American Chemical Society. The symposium, with more than 40 papers on the topic, will include experts from around the world who provide new insights into the compounds and particularly its biological effects.

All papers in this symposium are embargoed for Tuesday, Aug. 21, 9:00 a.m. The symposium will be held at the Boston Convention & Exhibition Center, Room 256. Selected papers are described below:

Dietary acrylamide may play a role in Alzheimer's, researchers theorize -- Scientists have known for years that acrylamide is capable of causing nerve damage in humans, including muscle weakness and impaired muscle coordination, particularly from industrial exposure to large levels of the chemical. Now, new laboratory studies suggest that chronic dietary exposure to the chemical is capable of damaging nerve cells in the brain and could potentially play a role in the development of neurodegenerative disease, including Alzheimer's, according to Richard LoPachin, Jr., Ph.D., a neurotoxicologist with Albert Einstein College of Medicine in New York. He notes that acrylamide is structurally similar to acrolein, a chemical found in increased levels in brains of patients with Alzheimer's and other neurodegenerative diseases. Studies in humans are warranted, the researcher says. (AGFD 079, Tuesday, Aug. 21, 9:55 a.m.)

Acrylamide not linked to breast cancer in U.S. women, Harvard study finds -- Foods that contain acrylamide are unlikely to cause breast cancer, according to preliminary results of a new study involving 100,000 U.S. women followed over a 20 year period. The study is the largest epidemiological study to date exploring the possible link between acrylamide and cancer in humans. Led by Lorelei Mucci, ScD, an epidemiologist at Harvard University School of Public Health in Boston, the study found that the incidence of breast cancer among women whose acrylamide consumption was considered high was roughly equal to the incidence among those whose acrylamide consumption was low. (AGFD 082, Tuesday, Aug. 21, 11:35 a.m.) FULL NEWS RELEASE AVAILABLE.

Acrylamide found in dried fruits -- Dried fruits, which are rich in fiber and antioxidants, have long been promoted as healthful alternatives to fresh fruits. Now, Thomas Amrein and his associates at the Swiss Federal Institute of Technology have found acrylamide in dried fruits, a surprising finding considering that these products are dried at relatively mild temperatures instead of the high temperatures, through baking and frying, that usually produce the chemical. The study suggests that acrylamide is capable of being formed under relatively mild conditions through reactions that are not fully understood, the researchers say. Of the different dried fruits tested, the highest concentrations of the chemical were found in dried pears and prunes, they say. (AGFD 197, Wednesday, Aug. 22, 10:15 a.m.).

Fat found to be significant source of acrylamide in food -- Studies have shown that carbohydrates and amino acids, particularly the non-essential amino acid asparagine, are the main chemicals in food that are responsible for acrylamide formation. Now, a new study by researchers in Spain indicates for the first time that dietary fats make a significant contribution to the formation of acrylamide. The researchers found that high fat levels in roasted almonds may account for as much as half of the acrylamide found in this food and likely accounts for high levels found in other high fat foods, according to study leader Francisco J. Hidalgo, Ph.D., of the Instituto de la Grasa in Seville. Although the researchers say they have not yet demonstrated that reducing fat content in foods actually reduces acrylamide, the study provides a new target to consider in efforts to reduce acrylamide formation. (AGFD 200, Wednesday, Aug. 22, 11:30 a.m.)

Farming techniques, biotechnology may help lower acrylamide -- Researchers in England are experimenting with novel agricultural practices and biotechnology in an effort to help reduce acrylamide levels in food crops. Nigel Halford, of Rothamsted Research, in collaboration with the University of Reading, says that increasing soil sulfur levels in wheat crops and reducing nitrogen availability in crops can decrease levels of asparagine, an acrylamide precursor. The researchers have also produced a new variety of potato through genetic modification that contains lower sugar levels than conventional potatoes and are targeting plant genes responsible for controlling asparagine levels in an effort to reduce acrylamide levels in food crops. (AGFD 241, Thursday, Aug. 23, 11:10 a.m.)

-end-
The American Chemical Society -- the world's largest scientific society -- is a nonprofit organization chartered by the U.S. Congress and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

-- Mark T. Sampson

Note for reporters' use only: For full information about the Boston meeting, including access to abstracts of more than 9,500 scientific papers and hundreds of non-technical summaries, visit http://www.acspresscenter.org. News release images are available at http://chemistry.org/bostonnews/images.html.

American Chemical Society

Related Breast Cancer Articles from Brightsurf:

Oncotarget: IGF2 expression in breast cancer tumors and in breast cancer cells
The Oncotarget authors propose that methylation of DVDMR represents a novel epigenetic biomarker that determines the levels of IGF2 protein expression in breast cancer.

Breast cancer: AI predicts which pre-malignant breast lesions will progress to advanced cancer
New research at Case Western Reserve University in Cleveland, Ohio, could help better determine which patients diagnosed with the pre-malignant breast cancer commonly as stage 0 are likely to progress to invasive breast cancer and therefore might benefit from additional therapy over and above surgery alone.

Partial breast irradiation effective treatment option for low-risk breast cancer
Partial breast irradiation produces similar long-term survival rates and risk for recurrence compared with whole breast irradiation for many women with low-risk, early stage breast cancer, according to new clinical data from a national clinical trial involving researchers from The Ohio State University Comprehensive Cancer Center - Arthur G.

Breast screening linked to 60 per cent lower risk of breast cancer death in first 10 years
Women who take part in breast screening have a significantly greater benefit from treatments than those who are not screened, according to a study of more than 50,000 women.

More clues revealed in link between normal breast changes and invasive breast cancer
A research team, led by investigators from Georgetown Lombardi Comprehensive Cancer Center, details how a natural and dramatic process -- changes in mammary glands to accommodate breastfeeding -- uses a molecular process believed to contribute to survival of pre-malignant breast cells.

Breast tissue tumor suppressor PTEN: A potential Achilles heel for breast cancer cells
A highly collaborative team of researchers at the Medical University of South Carolina and Ohio State University report in Nature Communications that they have identified a novel pathway for connective tissue PTEN in breast cancer cell response to radiotherapy.

Computers equal radiologists in assessing breast density and associated breast cancer risk
Automated breast-density evaluation was just as accurate in predicting women's risk of breast cancer, found and not found by mammography, as subjective evaluation done by radiologists, in a study led by researchers at UC San Francisco and Mayo Clinic.

Blood test can effectively rule out breast cancer, regardless of breast density
A new study published in PLOS ONE demonstrates that Videssa® Breast, a multi-protein biomarker blood test for breast cancer, is unaffected by breast density and can reliably rule out breast cancer in women with both dense and non-dense breast tissue.

Study shows influence of surgeons on likelihood of removal of healthy breast after breast cancer dia
Attending surgeons can have a strong influence on whether a patient undergoes contralateral prophylactic mastectomy after a diagnosis of breast cancer, according to a study published by JAMA Surgery.

Young breast cancer patients undergoing breast conserving surgery see improved prognosis
A new analysis indicates that breast cancer prognoses have improved over time in young women treated with breast conserving surgery.

Read More: Breast Cancer News and Breast Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.