Cereal Lessens Colon Cancer Risk

August 23, 1998

BOSTON, Mass.--Processing wheat bran in cereals by a method called extrusion processing increased the bran's cancer-fighting potential, when compared to raw wheat bran and flaked cereals in a study with laboratory rats conducted by the U.S. Department of Agriculture and the University of California. The findings were presented here today at the national meeting of the American Chemical Society, the world's largest scientific society. Prior animal and human studies have demonstrated the value of wheat bran in the diet in reducing the risk of colon cancer.

The six-month study showed up to a 40 percent reduction in the number of aberrant crypt cells in the colons of laboratory rats fed a controlled diet of extrusion-processed wheat bran, according to principal investigators Wallace Yokoyama, Ph.D., of the USDA's Western Regional Research Center in Albany, Calif., and Paul Davis, Ph.D., Division of Clinical Nutrition and Metabolism, Department of Internal Medicine, UC-Davis, who termed the reduction "significant."

Colon cancer is expected to kill more than 47,000 people in the U.S. this year and is the third leading cause of cancer death for men and women, according to the American Institute for Cancer Research and the American Cancer Society.

Previous research has demonstrated that people with colon cancer have a higher number of aberrant crypt cells, found in the lining of the colon. Raw wheat bran is known to reduce the number of "crypts," says Yokoyama. However, he noted, since most people typically do not have raw wheat bran in their diet, "there was an interest in determining if cereals containing processed wheat bran performed as well as raw wheat bran." Not only did it perform as well, claims Yokoyama, "processing of wheat bran actually improves its health-promoting properties."

It's still unclear to researchers how the wheat bran, raw or processed, reduces the number of aberrant crypt cells, although it appears to involve microbial action, according to Yokoyama.

Most cereals, whether wheat bran or another type, undergo processing. Extrusion processing involves squeezing, stirring and applying high shear forces, causing changes to the wheat bran, which Yokoyama believes increases the colon's absorption of the bran's healthy properties. The other primary method of cereal processing is flake processing, a much gentler process that causes less change to the wheat bran.

The test results are applicable only to processed wheat bran in cereals. "You would not get the same results from processed wheat bran in bread, for example, because there is very little shear involved in that processing," says Yokoyama.

Major funding for the research was provided by the Kellogg Company.

Dr. Davis will present his paper, AGFD 011, on Sunday, Aug.t 23, from 10:25 a.m. - 10:45 a.m. at Marriott Copley Place, Salon H/I, 4th Floor.

For further information, contact Nancy Blount from August 20-27 at Press Room, Convention Center, Room 308, Phone: (617) 351-6808, FAX:(617) 351-6820.

A nonprofit organization with a membership of more than 155,000 chemists and chemical engineers as its members, the American Chemical Society publishes scientific journals and databases, convenes major research conferences, and provides educational, science policy and career programs in chemistry. Its main offices are in Washington, D.C., and Columbus, Ohio.
-end-


American Chemical Society

Related Cancer Articles from Brightsurf:

New blood cancer treatment works by selectively interfering with cancer cell signalling
University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications.

UCI researchers uncover cancer cell vulnerabilities; may lead to better cancer therapies
A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy.

Breast cancer treatment costs highest among young women with metastic cancer
In a fight for their lives, young women, age 18-44, spend double the amount of older women to survive metastatic breast cancer, according to a large statewide study by the University of North Carolina at Chapel Hill.

Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.

Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.

Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.

Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells.

More cancer survivors, fewer cancer specialists point to challenge in meeting care needs
An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made.

New cancer vaccine platform a potential tool for efficacious targeted cancer therapy
Researchers at the University of Helsinki have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment.

American Cancer Society outlines blueprint for cancer control in the 21st century
The American Cancer Society is outlining its vision for cancer control in the decades ahead in a series of articles that forms the basis of a national cancer control plan.

Read More: Cancer News and Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.