Acrylamide exposure impairs blood-cerebrospinal fluid barrier function

August 24, 2014

The blood-brain barrier prevents xenobiotics from entering the central nervous system. Growing evidence indicates that neurotoxins, such as tributyltin, manganese and nanoparticles, may disrupt the function of the blood-brain and blood-cerebrospinal fluid (CSF) barriers. Previous studies show that chronic acrylamide exposure leads to central and peripheral neuropathy. However, very few studies have focused on the effects of acrylamide exposure on these barriers. Prof. Yanshu Zhang and co-workers from Hebei United University in China found that acrylamide exposure damages the blood-cerebrospinal fluid barrier and impairs secretory and transport functions. These changes may underlie acrylamide-induced neurotoxicity. The research achievements have been published in the Neural Regeneration Research.
-end-
Article: " Acrylamide exposure impairs blood-cerebrospinal fuid barrier function," by Xue Yao1, Licheng Yan1, Lin Yao2, Weijun Guan3, Fanxu Zeng1, Fuyuan Cao2, Yanshu Zhang1 (1 College of Public Health, Hebei United University, Tangshan, Hebei Province, China; 2 Experimental Animal Center, Hebei United University, Tangshan, Hebei Province, China; 3 Key Laboratory of Hebei Health and Safety on Coal Industry, Hebei United University, Tangshan, Hebei Province, China)

Yao X, Yan LC, Yao L, Guan WJ, Zeng FX, Cao FY, Zhang YS. Acrylamide exposure impairs blood-cerebrospinal fluid barrier function. Neural Regen Res. 2014;9(5):555-560

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/

Neural Regeneration Research

Related Acrylamide Articles from Brightsurf:

RUDN University chemist developed green method for malaria and leprosy drug production
A chemist from RUDN University suggested an eco-friendly method for the synthesis of dapsone, a substance that inhibits the growth of malaria and leprosy agents.

Novel PROTAC enhances its intracellular accumulation and protein knockdown
Researchers at Baylor College of Medicine developed an improved type of PROTAC that has enhanced intracellular accumulation and functions, not only as a degrader, but also as an inhibitor of the target protein.

Technology makes tissues elastic and lasting for easier imaging
By making brain and other tissues reversibly stretchable or compressible, a new MIT-developed technology called 'ELAST' allows labeling probes to infuse more quickly.

Time heals all wounds, but this adhesive can help
What if your Band-Aid® actually helped close your cuts and scrapes faster?

Nitric oxide-scavenging hydrogel developed for rheumatoid arthritis treatment
The research team of POSTECH utilized NO-cleavable-crosslinker that reacts to NO and developed a NO-scavenging nano-sized hydrogel (NO-Scv gel).

Inflate cells to observe their inner life
Cells are made up of organelles. Being able to observe these structures represents an enormous challenge.

Chemists created new diagnostic method for difficult climate conditions
Scientists from ITMO University developed a method to detect viral RNA without special equipment.

Polymer antibodies efficiently target and eliminate cancer cells
For the first time, researchers have produced polyfunctional nanoMIPs capable of selective target protein recognition and suitable for specific drug delivery.

Study: Drug-filled, 3-D printed dentures could fight off infections
University at Buffalo researchers have developed 3-D printed dentures filled with antifungal medication to better treat oral fungal infections.

From landfill to lipstick: Grape waste as a cosmetic and food ingredient
The world drinks a lot of wine, and that means a lot of grapes are consumed.

Read More: Acrylamide News and Acrylamide Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.