Research examines variations of rare lung disease

August 26, 2008

CINCINNATI - Lymphangioleiomyomatosis, or LAM, is a rare but serious lung disease that may cause severe respiratory symptoms in patients. The often-fatal disease has no cure.

Researchers say the key to learning more about LAM might lie in better understanding how symptoms differ among LAM patients

University of Cincinnati (UC) scientists are conducting a new research study that examines why symptoms of LAM are different in certain subgroups of people with the goal of finding more successful therapies.

LAM occurs when an unusual type of cell begins to grow out of control and spread to restricted areas in the body, including the lungs, kidneys, lymph nodes and vessels.

A team led by Jean Elwing, MD, an assistant professor in UC's pulmonary, critical care and sleep division, is enrolling female LAM patients to see if pulmonary hypertension and pulmonary vascular disease may be contributing to their respiratory symptoms.

Pulmonary hypertension is a blood vessel disorder of the lungs in which pressure in the pulmonary artery, the blood vessel that leads from the heart to the lungs, rises above normal levels.

"We plan to evaluate a group of women with LAM who are experiencing shortness of breath for the presence of pulmonary hypertension," she says. "We will look at participant's medical history, pulmonary function tests, exercise tolerance, echocardiogram results and previous biopsy samples.

"We are hopeful this information will increase our understanding of how LAM can manifest in the patients it affects. In the future, this information may be useful in developing better management strategies for this disease."

Elwing says this study will compare LAM patients who also have pulmonary hypertension with those who do not to differentiate between the groups.

"Some participants will be seen once in clinic and undergo testing with an echocardiogram while participating in this study," she says. "The individuals who have already undergone a clinical pulmonary hypertension evaluation may be able to participate through a review of select medical records and lung biopsy specimens."
-end-
This study is investigator-initiated and is funded by a Rhen Family Grant from the University of Cincinnati.

University of Cincinnati

Related Pulmonary Hypertension Articles from Brightsurf:

New virtual screening tool eases, accelerates routine diagnosis of pulmonary hypertension
The COVID-19 pandemic has increasing numbers of doctors caring for patients virtually.

Adding another dimension to a cell culture model for pulmonary arterial hypertension
Pulmonary arterial hypertension is a rare disease in which excessive proliferation of the cells of pulmonary arterial walls obstructs the blood flow in the lungs.

Casting a wider net to catch more cases of pulmonary hypertension
Investigators took an evidence-based approach to determine the lower end of the risk spectrum for PH based on pulmonary vascular resistance (PVR), which is resistance against blood flow from the pulmonary artery to the lungs.

Fusion protein holds promise for treating pulmonary arterial hypertension
In a paper published in Science Translational Medicine, researchers illuminate the underlying biological pathways that may lead to vessel destruction in pulmonary arterial hypertension.

New technical approach can enhance diagnosis of pulmonary hypertension
The management and prognosis of pulmonary hypertension heavily relies on whether the pathology is localized in pulmonary arteries or veins.

LSU Health study suggests nicotine exposure alone leads to pulmonary hypertension
A study conducted at LSU Health New Orleans has shown for the first time that chronic exposure to inhaled nicotine alone increases blood pressure in both the body's general circulation and in the lungs that can lead to pulmonary hypertension.

Specific gut bacteria may be associated with pulmonary arterial hypertension
Researchers have found a specific bacterial profile in the gut of people with pulmonary arterial hypertension, a chronic and progressive disease that causes constriction of arteries in the lungs.

Advancing an oral drug for pulmonary arterial hypertension
With a protein drug grown in the leaves of lettuce plants, the University of Pennsylvania's Henry Daniell and colleagues hope to provide new treatment options for patients with pulmonary arterial hypertension, a rare but deadly disease.

Antiarrhythmic drug identified as potential treatment for pulmonary arterial hypertension
High blood pressure in the lungs, known as pulmonary arterial hypertension (PAH), is a potentially fatal disease caused by obstruction of blood flow in the lungs.

Pulmonary arterial hypertension targeted for new treatment by Sheffield scientists
Scientists at the University of Sheffield, working in collaboration with drug and vaccine developer Kymab Ltd, Cambridge, have identified a novel antibody that has the potential to become a new treatment for pulmonary arterial hypertension (PAH).

Read More: Pulmonary Hypertension News and Pulmonary Hypertension Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.