Multiple-birth infants have higher risk of medical mixups in NICU

August 26, 2019

New York, NY (August 26, 2019)--Multiple-birth infants had a significantly higher risk of wrong-patient order errors compared with singletons in neonatal intensive care units (NICUs), according to a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian Hospital. The higher error rate was due to misidentification between siblings within sets of twins, triplets, or quadruplets.

The study was published online today in the journal JAMA Pediatrics.


Each year, more than 135,000 twins, triplets, and higher-order multiples are born in the United States.

Many are delivered prematurely and require over a month of treatment in a neonatal intensive care unit (NICU).

Wrong-patient order errors--orders for medications, tests, and procedures that are inadvertently written for the wrong patient--are more common in NICUs than in general pediatric care units.

"The challenge for NICU staff is that newborns lack distinguishing physical characteristics," says lead author Jason Adelman MD, MS, assistant professor of medicine at Columbia University Vagelos College of Physicians and Surgeons and chief patient safety officer at NewYork-Presbyterian/Columbia University Irving Medical Center. "This is compounded by the use of medical equipment that can obscure infants' physical features and the convention of identifying babies in the NICU with similar temporary names, such as Babyboy or Babygirl."

Adelman's prior research, published in Pediatrics, found that giving babies more distinctive names--such as Wendysboy--reduced the risk of wrong-patient order errors in the NICU by more than 36%.

Based on that study, The Joint Commission, which accredits healthcare organizations, now requires hospitals to adopt the new more distinct naming convention, along with other measures to minimize wrong-patient errors among newborns. "However, we suspected that the new naming convention may not protect multiples because siblings have the same last name and near-identical first names--for example, Wendysboy1 and Wendysboy2--placing them at risk of being mistaken for each other," says Adelman.

Study Details

To better understand the risk for multiples, the researchers analyzed more than 1.5 million electronic orders placed for 10,819 infants in six NICUs within two New York City hospital systems. Both systems were using the new naming convention.

The risk of making a wrong-patient order error was estimated using the Wrong-Patient Retract-and-Reorder (RAR) Measure, an algorithm devised by Adelman to identify near misses--orders incorrectly placed for one patient that are subsequently canceled and reordered for the intended patient. Although these near-miss errors are caught before causing harm, they occur frequently and follow the same pathway as errors that reach patients, making them a robust outcome for safety intervention studies.

What the Study Found

The risk of wrong-patient order errors was nearly doubled for multiples compared with singletons, the study found. Among multiples, errors between siblings--rather than unrelated infants--accounted for the excess risk. The risk grew with increasing number of siblings receiving care in the NICU: an error occurred in 1 in 7 sets of twins and in 1 of 3 sets of triplets and quadruplets.

The findings were consistent across study sites despite differences in patient populations and electronic health record systems.

"Our study suggests that the safeguards now commonly used to protect against medical errors in the NICU setting are not sufficient to prevent misidentification and medical errors among multiple-birth infants," Adelman says.

What's Next

Adelman's team is currently developing and testing a novel system for identifying newborns in the NICU.

"In the meantime, hospitals may be able to reduce the risk of errors among multiples in the NICU by using the newborns' given names when available or pseudonyms, and by switching from the temporary name to the given name as soon as it becomes available," says Adelman. "Clinicians may also consider encouraging parents--especially those expecting multiples--to select names or pseudonyms that can be used at birth."
Additional Information

The study is titled, "Risk of Wrong-Patient Orders Among Multiple vs Singleton Births in the Neonatal Intensive Care Units of 2 Integrated Health Care Systems." The other contributors are:

Jo R. Applebaum (NYPH); William N. Southern (Albert Einstein College of Medicine and Montefiore Health System); Clyde B. Schechter (Einstein); Judy L. Aschner (Einstein); Matthew A. Berger (Einstein and Montefiore); Andrew D. Racine (Einstein and Montefiore); Bejoy Chacko (Montefiore); Nina M. Dadlez (Floating Hospital for Children, Tufts Medical Center); Dena Goffman (CUIMC); John Babineau (NYPH and CUIMC); Robert A. Green (NYPH and CUIMC); David K. Vawdrey (CUIMC); Wilhelmina Manzano (NYPH); Daniel Barchi (NYPH); Craig Albanese (NYPH); David W. Bates (Brigham and Women's Hospital, Harvard Medical School, Boston, MA); and Hojjat Salmasian (Brigham and Women's Hospital, Harvard Medical School).

The study was funded by grants from the Agency for Healthcare Research and Quality of the National Institutes of Health (R01HS024538) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the National Institutes of Health (R01HD094793).

Columbia University Irving Medical Center

Columbia University Irving Medical Center provides international leadership in basic, preclinical, and clinical research; medical and health sciences education; and patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the Vagelos College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Columbia University Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest faculty medical practices in the Northeast. The campus that Columbia University Medical Center shares with its hospital partner, NewYork-Presbyterian, is now called the Columbia University Irving Medical Center. For more information, visit

Columbia University Irving Medical Center

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