New era in brain monitoring technology

August 27, 2020

GENEVA, SWITZERLAND - Today, the way a physician gets an idea of how many seizures a person with epilepsy has had is through the patient's own record of seizure activity in his day-to-day life. Despite all the technological advances in devices monitoring the human body, a patient's seizure diary, as it is often called, remains the only means to record and count epileptic seizures outside the clinic. Any insights that such a diary can provide on the effects of medication, seizure frequency or seizure triggers depend on the reliability and detail of the patient's reporting. Even accurate recognition of seizures is a problem since about half of seizures are not known to the patient.

A new generation of long-term brain monitoring technologies that continuously record brain activity in the clinic or at home is emerging and could greatly improve disease management for epilepsy patients. In an article published today in the journal Epilepsia, a team of scientists, engineers and clinicians from around the world describe how an innovative approach that records neural activity from beneath the scalp could provide a reliable alternative to subjective seizure diaries. These innovative devices are subscalp electroencephalography (EEG) systems that are minimally invasive and could remain underneath the scalp for long periods of time.

Maxime Baud, MD, PhD, epileptologist at Bern University Hospital, Wyss Center Staff Neurologist and co-author of the paper said: "Our current epilepsy treatment plans are primarily based on short-term brain activity data from EEG caps during a hospital visit. Epileptic seizures can occur months apart and come in cycles, so we need ways to, continuously and accurately, monitor brain activity in the home environment. With the Wyss Center's Epios system, we are excited to be part of the movement developing such new technologies, that can ultimately enable us to optimize and personalize treatment for each patient."

Six new technologies, commercially available or under development, are described in the paper each with a different primary value including seizure counting and recording, seizure forecasting and alerting, and neuro-stimulation. These minimally invasive techniques may help avoid some of the risks linked to directly intervening in the brain.

One of these subscalp devices is Minder, being developed by the Australian company Epi-Minder. Currently in clinical trials, the device's multichannel electrode is placed across the skull so that both brain hemispheres are covered. "Through long-term and continuous EEG measurements, Minder aims to provide accurate knowledge of brain activity and seizures to help people with epilepsy take back control of their lives," said Professor Mark Cook, MD, PhD, Chair of Medicine at the University of Melbourne, Director of Neurology at St Vincent's Hospital, Melbourne and co-author of the paper.

Another technology reviewed in the paper is the Wyss Center's EpiosTM system, designed to offer flexible subscalp configurations, from focal or bitemporal electrode layouts to broad head coverage and high-channel-count neural recording, through a series of thin sensing electrodes connected to a miniature implant, all inserted beneath the skin. The neural signals are wirelessly transmitted to an external (behind-the-ear) receiver, while a wearable data processor enhances brain data with heart rate, accelerometry and audio data and uploads it to the Epios Cloud, which offers secure and centralized data storage, annotation and visualization.

"In parallel to the recording devices, we are constantly optimizing our high performance analytics software with algorithms that could help clinicians draw meaningful conclusions from the vast amount of data recorded by these long-term systems," George Kouvas, MBA, Chief Technology Officer at the Wyss Center and co-author of the paper said. "We are already working towards adapting these new technologies to help patients with other brain disorders manage their daily life, such as with tinnitus and stroke," Kouvas added.

Future uses for long-term, subscalp brain monitoring include biomarker detection and efficacy monitoring of pharmaceuticals as well as well as closed-loop neuromodulation applications.

The technologies reviewed in the paper are:

24/7 EEG™ SubQ from UNEEG medical A/S, Lynge, Denmark;

The Epicranial Application of Stimulation Electrodes for Epilepsy (EASEE) from Precisis AG, Heidelberg, Germany;

The Epios™ system from the Wyss Center for Bio and Neuroengineering, Geneva, Switzerland;

Minder from Epi-Minder Pty Ltd, Melbourne, Australia;

The Neuroview Technology from Englewood, USA;

UltimateEEG from BrainCare Oy Ltd., Tampere, Finland.

The article: A new era in electroencephalographic monitoring? Subscalp devices for ultra-long-term recordings is published in Epilepsia and will be available at: https://onlinelibrary.wiley.com/doi/full/10.1111/epi.16630
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About the Wyss Center for Bio and Neuroengineering, Geneva, Switzerland

The Wyss Center is an independent, non-profit research and development organization that advances our understanding of the brain to realize therapies and improve lives.

The Wyss Center staff, together with the Center's academic, clinical and industrial collaborators, pursue innovations and new approaches in neurobiology, neuroimaging and neurotechnology. Wyss Center advances reveal unique insights into the mechanisms underlying the dynamics of the brain and the treatment of disease to accelerate the development of devices and therapies for unmet medical needs.

The Wyss Center was established by a generous donation from the Swiss entrepreneur and philanthropist Hansjörg Wyss in 2014. Additional resources from funding agencies and other sources help the Wyss Center accelerate its mission.

http://www.wysscenter.ch/

MEDIA CONTACTS:


Wyss Center
Jo Bowler, Media and Public Relations Manager
+41 (0) 58 201 03 09
johanna.bowler@wysscenter.ch

Wyss Center for Bio and Neuroengineering

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